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1. 发明授权

US06095986A Disposable anti-fog airway adapter 失效
标题翻译：一次性防雾气道适配器
公开(公告)号：US06095986A
公开(公告)日：2000-08-01
申请号：US123232
申请日：1998-07-28
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
IPC分类号： A61B5/097 , A61B5/08
CPC分类号： A61B5/097
摘要： A disposable anti-fog airway adapter for use with a mainstream respiratory gas analyzer which provides a measurement of a patient's inhaled and exhaled gases. The airway adapter includes windows that are constructed of a thin, low heat capacity plastic that rapidly equilibrates to the temperature of the warm moist gases in the patient breathing circuit. In addition, the inside of the windows is also coated with an anti-fog surfactant either by laminating an anti-fog film with the window plastic prior to attaching the window to the airway adapter body or by first attaching the window to the airway adapter body and then applying the surfactant to the airway adapter after the window film is bonded in place so that the surfactant coats the entire inside of the adapter. The surfactant functions to increase the critical wetting tension of the surface it covers so that water on the window spreads into a uniform thin layer which does not absorb very much infrared energy and thus does not significantly reduce the signal strength. "Instant on" operation is accomplished because no heater and the like is necessary to warm up the windows to maintain them at an elevated temperature to prevent fogging. Numerous techniques are also provided for adhering the windows to the airway adapter body so that a substantially airtight seal may be obtained.
摘要翻译：用于主流呼吸气体分析仪的一次性防雾气道适配器，其提供对患者的吸入和呼出气体的测量。气道适配器包括由能够快速平衡到患者呼吸回路中的温湿润气体的温度的薄的低热容塑料构成的窗户。此外，窗户的内部还通过在将窗口附接到气道适配器主体之前层叠防雾膜与窗户塑料，或者通过首先将窗口附接到气道适配器本体上来涂覆防雾表面活性剂然后在将窗膜粘合就位后将表面活性剂施用于气道适配器，使得表面活性剂涂覆在适配器的整个内部。表面活性剂用于增加其覆盖的表面的临界润湿张力，使得窗户上的水扩散到不吸收非常多的红外能量的均匀薄层，因此不显着降低信号强度。实现“即时打开”操作，因为不需要加热器等来预热窗户以将其保持在高温以防止起雾。还提供了许多技术用于将窗口粘附到气道适配器主体，使得可以获得基本上气密的密封。

2. 发明授权

US5296706A Shutterless mainstream discriminating anesthetic agent analyzer 失效
标题翻译：快门主流鉴别麻醉剂分析仪
公开(公告)号：US5296706A
公开(公告)日：1994-03-22
申请号：US985793
申请日：1992-12-02
申请人： James R. Braig , Daniel S. Goldberger , Mark L. Yelderman , Roger O. Herrera
发明人： James R. Braig , Daniel S. Goldberger , Mark L. Yelderman , Roger O. Herrera
IPC分类号： G01J5/06 , G01J5/12 , G01N21/31 , G01N21/35 , G01J5/2
CPC分类号： G01N21/3581 , G01N21/3504 , G01J2005/066 , G01J5/12 , G01N2021/3129 , G01N2021/3166
摘要： An anesthetic agent analyzer having six or more independent analytical channels, where each channel comprises a first thermopile which receives incident infrared radiation and a second thermopile behind the first thermopile which is blocked from the incident infrared radiation and thus serves as a reference for detecting ambient temperature variations. The first and second thermopiles are connected in a "parallel opposed" fashion so that the effects of ambient temperature variations automatically cancel and the detectors may be readily configured in a detector package. The anesthetic agent analyzer of the invention is designed for use with a wideband infrared radiation source so that anesthetic agents having characteristic absorption bands in the far infrared wavelength range (6-15 microns) may be more readily detected and discriminated. When implemented in a mainstream configuration, a disposable airway adapter with windows formed of polypropylene or some other suitable window material which minimally attenuates the infrared energy at the wavelengths of interest is also used. The concentrations of the discriminated anesthetic agent gases are then calculated using a second order polynomial equation having cross product terms. By connecting the first and second thermopiles in a back to back configuration, the detector device of the invention permits twice as many independent analytical channels to be provided in the same substrate area, with the resultant reduction in ambient temperature gradients.
摘要翻译：具有六个或更多个独立分析通道的麻醉剂分析器，其中每个通道包括接收入射的红外辐射的第一热电堆和第一热电堆后面的第二热电堆，其被阻挡入射的红外辐射，因此用作检测环境温度的参考变化。第一和第二热电堆以“平行相对”的方式连接，使得环境温度变化的影响自动消除，并且检测器可以容易地配置在检测器封装中。本发明的麻醉剂分析仪被设计用于宽带红外辐射源，从而可以更容易地检测和鉴别具有远红外波长范围（6-15微米）特征吸收带的麻醉剂。当以主流配置实施时，还使用具有由聚丙烯形成的窗口的一次性气道适配器或一些其它合适的窗口材料，其最小程度地衰减感兴趣的波长处的红外能量。然后使用具有交叉乘积项的二阶多项式方程来计算鉴别的麻醉剂气体的浓度。通过以背靠背的形式连接第一和第二热电堆，本发明的检测器装置允许在同一衬底区域中提供两倍的独立分析通道，从而降低环境温度梯度。

3. 外观设计

USD342135S Airway adapter 失效
公开(公告)号：USD342135S
公开(公告)日：1993-12-07
申请号：US784047
申请日：1991-10-28
申请人： Daniel S. Goldberger , William J. Wohltmann , James R. Braig , Mark L. Yelderman
设计人： Daniel S. Goldberger , William J. Wohltmann , James R. Braig , Mark L. Yelderman

4. 发明授权

US5281817A Method of selecting an optical filter for a shutterless optically stabilized capnograph 失效
标题翻译：选择无光闸光学稳定捕集仪的滤光片的方法
公开(公告)号：US5281817A
公开(公告)日：1994-01-25
申请号：US782991
申请日：1991-10-28
申请人： Mark L. Yelderman , James R. Braig , Daniel S. Goldberger
发明人： Mark L. Yelderman , James R. Braig , Daniel S. Goldberger
IPC分类号： A61B5/083 , G01J1/24 , G01J5/12 , G01N21/31 , G01N21/35 , G01N21/61 , G01J3/51
CPC分类号： G01N21/3504 , A61B5/083 , G01J1/24 , G01J5/12 , G01N2021/3166 , G01N2201/126
摘要： Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of optically filtered thermopiles in series and processing the resulting differential pair. In addition, techniques are provided for selecting overlapping optical filters for use with thermopiles with a minimum level of cross-talk. A processing technique is also given which allows the concentrations of two or more airstream constituents to be separately quantified even when such overlapping optical filters are used.
摘要翻译：公开了用于构造光学稳定的无闸门红外捕集仪的方法和装置。本发明的血氧监护仪提供了患者的呼吸气流的成分的绝对浓度，而没有通常与热电堆检测器相关的热漂移问题，从而提供高精度的装置。本发明不需要机械快门来调制入射的红外光束和调制源的需要，从而增加所公开的设备的可靠性和响应时间。基本上不受其工作环境温度变化影响的测井仪通过串联连接成对的光学过滤的热电堆并处理所得的差分对来提供。另外，提供了用于选择具有最低水平的串扰的热电堆使用的重叠光学滤波器的技术。还给出了即使使用这种重叠的光学滤波器也允许分开量化两种或更多种气流成分的浓度的处理技术。

5. 发明授权

US06387052B1 Thermodilution catheter having a safe, flexible heating element 失效
公开(公告)号：US06387052B1
公开(公告)日：2002-05-14
申请号：US08049231
申请日：1993-04-19
申请人： Michael D. Quinn , Mark L. Yelderman
发明人： Michael D. Quinn , Mark L. Yelderman
IPC分类号： A61B500
CPC分类号： A61B5/6855 , A61B5/028 , A61B5/1495 , A61B5/6856 , A61B5/6857 , A61B18/14 , A61B2017/00482 , A61B2018/00178 , A61B2018/00666 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00988 , A61B2562/08
摘要： A thermodilution catheter having a heating filament which is fabricated so as to be thin and flexible enough to avoid contact with the patient's blood. The heating filament is either inserted in a preformed catheter lumen, incorporated into a wall of the catheter body itself, or wrapped around the catheter body wall and surrounded by an external sheath. Generally, the covering of the heating filament is minimally thin so as to allow the heat from the heating filament to be transferred to the surrounding blood and to minimally increase the overall cross-sectional area. Since the heating filament does not directly touch the patient's blood, the outer surface may be made smooth so as to prevent inducement of blood clots. In addition, the heating filament may be maintained at a safe temperature by forming the heating element of a flexible material having a high temperature coefficient of resistance, low thermal capacitance and high thermal conductivity. Preferably, the temperature coefficient of resistance of the material forming the heater filament is greater than 0.001 &OHgr;/&OHgr;-° C. and the resistance of the heating filament is proportional or inversely proportional to its temperature. By monitoring this resistance, the application of power to the heating filament may be regulated to prevent overheating of the heating filament. Calibration techniques are also disclosed whereby a memory containing encoded calibration information is disposed within or connected to a connector of the catheter. This memory may also include a program segment used by a cardiac output computer having a cardiac output calculation program, whereby the portion of code stored in the memory must be input into the cardiac output computer before the determination of the cardiac output can be performed. As a result of these improvements, the invention enables the thermodilution cardiac output calculation to be performed quite safely and accurately in a clinical setting.

6. 发明授权

US5755670A System and method for controlling the temperature of a catheter-mounted heater 失效
公开(公告)号：US5755670A
公开(公告)日：1998-05-26
申请号：US603552
申请日：1996-02-21
申请人： Russell C. McKown , Michael D. Quinn , Mark L. Yelderman
发明人： Russell C. McKown , Michael D. Quinn , Mark L. Yelderman
IPC分类号： A61B5/00 , A61B5/028 , A61B18/14 , G05D23/24
CPC分类号： A61B5/6855 , A61B18/14 , A61B5/028 , A61B5/1495 , A61B5/6856 , A61B5/6857 , G05D23/2401 , A61B2017/00482 , A61B2018/00166 , A61B2018/00178 , A61B2018/00666 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00988 , A61B2562/08
摘要： A system for keeping the surface temperature of an electric resistance-type heater element in a thermodilution catheter within safe physiological limits includes, in the preferred embodiment, a heater element core temperature monitor, a monitor for monitoring the power that is supplied to the heater element, and a surface temperature calculator for calculating the surface temperature of the heater element based on the core temperature, supplied power, and information representing the characteristics of the particular catheter under anticipated clinical conditions. A second aspect of the invention involves a system for determining the supply of power to the heater element based on the core temperature of the heater element. A third aspect of the invention involves a system readiness test for determining, in vivo, that the thermodilution catheter system is properly calibrated before the system is operational. Methods of operation for each of the above-referenced aspects of the invention are also disclosed.

7. 发明授权

US07254946B1 Thermodilution catheter having a safe, flexible heating element 失效
公开(公告)号：US07254946B1
公开(公告)日：2007-08-14
申请号：US08420503
申请日：1995-04-12
申请人： Michael D. Quinn , Mark L. Yelderman
发明人： Michael D. Quinn , Mark L. Yelderman
IPC分类号： A61B5/02
CPC分类号： A61B5/6855 , A61B5/028 , A61B5/1495 , A61B5/6856 , A61B5/6857 , A61B18/14 , A61B2017/00482 , A61B2018/00178 , A61B2018/00666 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00988 , A61B2562/08
摘要： A thermodilution catheter having a heating filament which is fabricated so as to be thin and flexible enough to avoid contact with the patient's blood. The heating filament is either inserted in a preformed catheter lumen, incorporated into a wall of the catheter body itself, or wrapped around the catheter body wall and surrounded by an external sheath. Generally, the covering of the heating filament is minimally thin so as to allow the heat from the heating filament to be transferred to the surrounding blood and to minimally increase the overall cross-sectional area. Since the heating filament does not directly touch the patient's blood, the outer surface may be made smooth so as to prevent inducement of blood clots. In addition, the heating filament may be maintained at a safe temperature by forming the heating element of a flexible material having a high temperature coefficient of resistance, low thermal capacitance and high thermal conductivity. Preferably, the temperature coefficient of resistance of the material forming the heater filament is greater than 0.001 Ω/Ω-° C. and the resistance of the heating filament is proportional or inversely proportional to its temperature. By monitoring this resistance, the application of power to the heating filament may be regulated to prevent overheating of the heating filament. Calibration techniques are also disclosed whereby a memory containing encoded calibration information is disposed within or connected to a connector of the catheter. This memory may also include a program segment used by a cardiac output computer having a cardiac output calculation program, whereby the portion of code stored in the memory must be input into the cardiac output computer before the determination of the cardiac output can be performed. As a result of these improvements, the invention enables the thermodilution cardiac output calculation to be performed quite safely and accurately in a clinical setting.

8. 发明授权

US06485430B1 Thermodilution catheter having a safe, flexible heating element 失效
公开(公告)号：US06485430B1
公开(公告)日：2002-11-26
申请号：US08603550
申请日：1996-02-21
申请人： Michael D. Quinn , Mark L. Yelderman
发明人： Michael D. Quinn , Mark L. Yelderman
IPC分类号： A61B500
CPC分类号： A61B5/6855 , A61B5/028 , A61B5/1495 , A61B5/6856 , A61B5/6857 , A61B18/14 , A61B2017/00482 , A61B2018/00178 , A61B2018/00666 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00988 , A61B2562/08
摘要： A thermodilution catheter having a heating filament which is fabricated so as to be thin and flexible enough to avoid contact with the patient's blood. The heating filament is either inserted in a preformed catheter lumen, incorporated into a wall of the catheter body itself, or wrapped around the catheter body wall and surrounded by an external sheath. Generally, the covering of the heating filament is minimally thin so as to allow the heat from the heating filament to be transferred to the surrounding blood and to minimally increase the overall cross-sectional area. Since the heating filament does not directly touch the patient's blood, the outer surface may be made smooth so as to prevent inducement of blood clots. In addition, the heating filament may be maintained at a safe temperature by forming the heating element of a flexible material having a high temperature coefficient of resistance, low thermal capacitance and high thermal conductivity. Preferably, the temperature coefficient of resistance of the material forming the heater filament is greater than 0.001 &OHgr;/&OHgr;−° C. and the resistance of the heating filament is proportional or inversely proportional to its temperature. By monitoring this resistance, the application of power to the heating filament may be regulated to prevent overheating of the heating filament. Calibration techniques are also disclosed whereby a memory containing encoded calibration information is disposed within or connected to a connector of the catheter. This memory may also include a program segment used by a cardiac output computer having a cardiac output calculation program, whereby the portion of code stored in the memory must be input into the cardiac output computer before the determination of the cardiac output can be performed. As a result of these improvements, the invention enables the thermodilution cardiac output calculation to be performed quite safely and accurately in a clinical setting.

9. 发明授权

US6036654A Multi-lumen, multi-parameter catheter 失效
标题翻译：多腔多参数导管
公开(公告)号：US6036654A
公开(公告)日：2000-03-14
申请号：US311477
申请日：1994-09-23
申请人： Michael D. Quinn , Jaime Siman , Mark L. Yelderman
发明人： Michael D. Quinn , Jaime Siman , Mark L. Yelderman
IPC分类号： A61B5/00 , A61B5/028 , A61B5/02
CPC分类号： A61B5/6852 , A61B5/028 , A61B5/1459
摘要： A multi-lumen catheter capable of measuring cardiac output continuously, mixed venous oxygen saturation as well as other hemodynamic parameters. The catheter is also capable of undertaking therapeutic operations such as drug infusion and cardiac pacing. The catheter includes optical fibers for coupling to an external oximeter, an injectate port and thermistor for bolus thermodilution measurements, a heating element for inputting a heat signal and for coupling to an external processor for continuously measuring cardiac output, and a distal lumen for measuring pressure, withdrawing blood, guidewire passage or drug infusion. In a preferred embodiment, the catheter includes a novel lumen configuration permitting an additional infusion lumen for either fast drug infusion or cardiac pacing.
摘要翻译：可以连续测量心输出量的多腔导管，混合静脉血氧饱和度以及其他血液动力学参数。导管还能够进行治疗操作，例如药物输注和心脏起搏。导管包括用于耦合到外部血氧计的光纤，用于推注热稀释测量的注射端口和热敏电阻，用于输入热信号并耦合到外部处理器以连续测量心输出量的加热元件，以及用于测量压力的远端内腔，抽血，导丝通过或药物输注。在优选实施例中，导管包括允许另外的输注腔用于快速药物输注或心脏起搏的新型管腔构型。

10. 发明授权

US5807269A Thermodilution catheter having a safe, flexible heating element 失效
公开(公告)号：US5807269A
公开(公告)日：1998-09-15
申请号：US485124
申请日：1995-06-07
申请人： Michael D. Quinn , Mark L. Yelderman
发明人： Michael D. Quinn , Mark L. Yelderman
IPC分类号： A61B5/00 , A61B5/028 , A61B18/14
CPC分类号： A61B5/6855 , A61B18/14 , A61B5/028 , A61B5/1495 , A61B5/6856 , A61B5/6857 , A61B2017/00482 , A61B2018/00178 , A61B2018/00666 , A61B2018/00678 , A61B2018/00708 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00988 , A61B2562/08
摘要： A thermodilution catheter having a heating filament which is fabricated so as to be thin and flexible enough to avoid contact with the patient's blood. The heating filament is either inserted in a preformed catheter lumen, incorporated into a wall of the catheter body itself, or wrapped around the catheter body wall and surrounded by an external sheath. Generally, the covering of the heating filament is minimally thin so as to allow the heat from the heating filament to be transferred to the surrounding blood and to minimally increase the overall cross-sectional area. Since the heating filament does not directly touch the patient's blood, the outer surface may be made smooth so as to prevent inducement of blood clots. In addition, the heating filament may be maintained at a safe temperature by forming the heating element of a flexible material having a high temperature coefficient of resistance, low thermal capacitance and high thermal conductivity. Preferably, the temperature coefficient of resistance of the material forming the heater filament is greater than 0.001.OMEGA./.OMEGA.-.degree.C. and the resistance of the heating filament is proportional or inversely proportional to its temperature. By monitoring this resistance, the application of power to the heating filament may be regulated to prevent overheating of the heating filament. Calibration techniques are also disclosed whereby a memory containing encoded calibration information is disposed within or connected to a connector of the catheter. This memory may also include a program segment used by a cardiac output computer having a cardiac output calculation program, whereby the portion of code stored in the memory must be input into the cardiac output computer before the determination of the cardiac output can be performed. As a result of these improvements, the invention enables the thermodilution cardiac output calculation to be performed quite safely and accurately in a clinical setting.

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