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    • 2. 发明申请
    • APPARATUS AND METHOD FOR PREDICTING GENE MODULES USING GENE EXPRESSION AND TRANSCRIPTION FACTOR BINDING INFORMATION
    • 使用基因表达和转录因子绑定信息预测基因模块的装置和方法
    • US20080140373A1
    • 2008-06-12
    • US11930392
    • 2007-10-31
    • Ho-Youl JUNGMin-Ho KIMMyung-Guen CHUNGPo-Ra KIMSeon-Hee PARKSoo-Jun PARK
    • Ho-Youl JUNGMin-Ho KIMMyung-Guen CHUNGPo-Ra KIMSeon-Hee PARKSoo-Jun PARK
    • G06G7/48
    • G16B45/00G16B25/00G16B40/00
    • Provided is an apparatus and method for predicting gene modules controlled by the same set of transcription factors and performing the same function in a cell, using gene expression data and transcription factor binding information. The apparatus includes: a gene expression similarity matrix generator for generating gene expression similarity matrix using gene expression data from external gene expression database; a gene expression similarity graph generator for generating gene expression similarity graph using the gene expression similarity matrix generated from the gene expression similarity matrix generator; a dense subgraph generator for generating dense subgraph by applying a dense subgraph algorithm to the gene expression similarity graph generated from the gene expression similarity graph generator; and a significant gene module generator for generating a significant gene module by extracting transcription factor binding information from an external transcription factor binding database using the dense subgraph generated from the dense subgraph generator.
    • 提供了一种用于预测由相同组转录因子控制的基因模块并使用基因表达数据和转录因子结合信息在细胞中执行相同功能的装置和方法。 该装置包括:使用来自外部基因表达数据库的基因表达数据产生基因表达相似性矩阵的基因表达相似性矩阵发生器; 基因表达相似图生成器,用于使用从基因表达相似矩阵生成器产生的基因表达相似性矩阵来产生基因表达相似图; 通过将密集子图算法应用于从基因表达相似图生成器生成的基因表达相似图,生成致密子图的致密子图生成器; 以及用于通过使用从密集子图生成器生成的致密子图从外部转录因子结合数据库提取转录因子结合信息来产生重要基因模块的重要基因模块发生器。
    • 3. 发明申请
    • APPARATUS AND METHOD FOR COMPARING PROTEIN STRUCTURES USING PRINCIPAL COMPONENTS ANALYSIS AND AUTOCORRELATION
    • 使用主成分分析和自动对比来比较蛋白质结构的装置和方法
    • US20080133632A1
    • 2008-06-05
    • US11877150
    • 2007-10-23
    • Dae-Hee KIMSung-Hee PARKChan-Yong PARKSoo-Jun PARKSeon-Hee PARK
    • Dae-Hee KIMSung-Hee PARKChan-Yong PARKSoo-Jun PARKSeon-Hee PARK
    • G06F17/14G06F17/15
    • G06K9/6203G16B15/00G16B40/00
    • Provided is an apparatus and method for comparing structures of proteins by extracting main axes of the proteins using principal components analysis (PCA), dividing regions using grids into voxels for precise structure alignment, and placing the proteins respectively in the regions to calculate a similarity between the proteins by autocorrelation. The apparatus for comparing protein structures using principal components analysis (PCA) and autocorrelation includes: a PCA calculator for receiving a query protein for extracting a main axis of the query protein; a voxel generator for receiving information about the main axis from the PCA calculator and dividing a predetermined region using a grid to determine whether the divided region is occupied by the query protein for generating voxels of the query protein; and a comparison processor for performing an autocorrelation calculation between voxels of one protein and voxels of the other protein that are generated by the voxel generator.
    • 本发明提供了一种用于通过使用主成分分析(PCA)提取蛋白质的主轴来分类蛋白质的结构的装置和方法,将使用网格的分割区域分割成体素以进行精确的结构比对,并将蛋白质分别置于区域中以计算蛋白质之间的相似性 蛋白质通过自相关。 用于使用主成分分析(PCA)和自相关比较蛋白质结构的装置包括:用于接收用于提取查询蛋白质的主轴的查询蛋白质的PCA计算器; 用于从PCA计算器接收关于主轴的信息并使用网格划分预定区域以确定分割区域是否被查询蛋白质占据以产生查询蛋白质的体素的体素生成器; 以及比较处理器,用于在体素生成器生成的一个蛋白的体素和另一个蛋白的体素之间执行自相关计算。