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1. 发明专利

CA2612672C TREATMENT FOR SEXUAL DYSFUNCTION 未知
公开(公告)号：CA2612672C
公开(公告)日：2014-10-14
申请号：CA2612672
申请日：2006-06-13
申请人： JANSSEN PHARMACEUTICA NV
发明人： PALUMBO JOSEPH , SPORN JOHATHAN , STECKLER THOMAS , CHOI YONG , LEE JAMES S
IPC分类号： A61K31/27 , A61P15/00 , A61P15/10
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

2. 发明专利

RS51269B UPOTREBA 2-FENIL-1,2-ETANDIOL-(DI)KARBAMATA ZA TRETIRANJE EPILEPTOGENEZE 未知
公开(公告)号：RS51269B
公开(公告)日：2010-12-31
申请号：RSP20100264
申请日：2005-09-15
申请人： JANSSEN PHARMACEUTICA NV
发明人： PLATA-SALAMAN CARLOS , ZHAO BOYU , TWYMAN ROY , GORDON ROBERT , CHOI YONG , NOVAK GERALD , WHITE STEVE
IPC分类号： A61K31/27 , A61P25/08
摘要： Jedinjenje, ili njegova farmaceutski prihvatljiva so ili njegov estar, biraju se iz grupe koju čine Formula (I) i Formula (II):pri čemu,fenil je supstituisan u položaju X sa jednim do pet atoma halogena, koji se biraju iz grupe koju čine fluor, hlor, brom i jod; aR1, R2, R3, R4, R5 i R6 se nezavisno biraju iz grupe koju čine vodonik i C1-C4 alkil; pri čemu je C1-C4 alkil opciono supstituisan sa fenil (pri čemu je fenil opciono supstituisan sa supstituentima koji se nezavisno biraju iz grupe koju čine halogen, C1-C4 alkil, C1-C4 alkoksi, amino, nitro i cijano),koje se upotrebljava za tretiranje, prevenciju, uzvraćanje, zaustavljanje ili inhibiciju epileptogeneze kod nekog humanog subjekta koji je pod rizikom razvoja epilepsije ili nekog poremećaja povezanog sa napadima, ali nema epilepsiju ili kliničke znake napada.Prijava sadrži još 39 zavisnih patentnih zahteva.

3. 发明专利

CA2612672A1 TREATMENT OF SEXUAL DYSFUNCTION 未知
公开(公告)号：CA2612672A1
公开(公告)日：2007-01-04
申请号：CA2612672
申请日：2006-06-13
申请人： JANSSEN PHARMACEUTICA NV
发明人： CHOI YONG , PALUMBO JOSEPH , LEE JAMES S , STECKLER THOMAS , SPORN JOHATHAN
IPC分类号： A61P15/10 , A61K31/165
摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt o r ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, B r and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethy l, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, wi th the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from t he group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

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