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1. 发明授权

US07767821B2 Long wavelength thiol-reactive fluorophores 有权
标题翻译：长波长硫醇反应性荧光团
公开(公告)号：US07767821B2
公开(公告)日：2010-08-03
申请号：US12489078
申请日：2009-06-22
申请人： J. Bruce Pitner , Douglas B. Sherman , Joseph Thomas
发明人： J. Bruce Pitner , Douglas B. Sherman , Joseph Thomas
IPC分类号： C07D413/06 , A61K31/538 , G01N33/48
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译：公开了活性荧光染料组合物及其使用方法。揭示了具有硫醇反应性基团的方钠核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料。披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。公开了具有结合蛋白和方酸核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核的生物传感器。

2. 发明授权

US07563891B2 Long wavelength thiol-reactive fluorophores 有权
标题翻译：长波长硫醇反应性荧光团
公开(公告)号：US07563891B2
公开(公告)日：2009-07-21
申请号：US11131283
申请日：2005-05-18
申请人： J. Bruce Pitner , Douglas B. Sherman , Arounaguiry Ambroise , Joseph Thomas
发明人： J. Bruce Pitner , Douglas B. Sherman , Arounaguiry Ambroise , Joseph Thomas
IPC分类号： C07D413/06 , A61K31/538 , G01N33/48
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译：公开了活性荧光染料组合物及其使用方法。揭示了具有硫醇反应性基团的方钠核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料。披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。公开了具有结合蛋白和方酸核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核的生物传感器。

3. 发明授权

US08129525B2 Long wavelength thiol-reactive fluorophores 有权
标题翻译：长波长硫醇反应性荧光团
公开(公告)号：US08129525B2
公开(公告)日：2012-03-06
申请号：US12489121
申请日：2009-06-22
申请人： J. Bruce Pitner , Douglas B. Sherman , Arounaguiry Ambroise , Joseph Thomas
发明人： J. Bruce Pitner , Douglas B. Sherman , Arounaguiry Ambroise , Joseph Thomas
IPC分类号： C07D413/06
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Nile Red nucleus dyes are disclosed having thiol-reactive groups. Nile Red nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. The Nile Red nucleus dyes are of the following formulae:
摘要翻译：公开了活性荧光染料组合物及其使用方法。公开了尼罗红核染料具有硫醇反应性基团。公开了展现至少约575nm的荧光发射的尼罗河红核染料。尼罗红色核染料具有下列公式：

4. 发明授权

US08071794B2 Long wavelength thiol-reactive fluorophores 有权
标题翻译：长波长硫醇反应性荧光团
公开(公告)号：US08071794B2
公开(公告)日：2011-12-06
申请号：US12489145
申请日：2009-06-22
申请人： J. Bruce Pitner , Douglas B. Sherman , Joseph Thomas
发明人： J. Bruce Pitner , Douglas B. Sherman , Joseph Thomas
IPC分类号： C07D413/06 , A61K31/538 , G01N33/48
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译：公开了活性荧光染料组合物及其使用方法。揭示了具有硫醇反应性基团的方钠核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料。披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。公开了具有结合蛋白和方酸核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核的生物传感器。

5. 发明授权

US08962342B2 Near-infrared dyes as surface enhanced raman scattering reporters 有权
标题翻译：近红外染料作为表面增强的拉曼散射记者
公开(公告)号：US08962342B2
公开(公告)日：2015-02-24
申请号：US12134594
申请日：2008-06-06
申请人： Joseph Thomas , Rajendra R. Bhat , W. Shannon Dillmore , Douglas B. Sherman
发明人： Joseph Thomas , Rajendra R. Bhat , W. Shannon Dillmore , Douglas B. Sherman
IPC分类号： G01N21/65 , G01N33/58 , A61K49/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C09B23/10 , C09B63/00
CPC分类号： G01N21/658 , A61K49/0021 , A61K49/0065 , A61K49/0093 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07D265/36 , C07D405/06 , C07D417/06 , C09B23/105 , C09B63/00 , G01N33/587 , G01N2201/06113 , Y10T428/2982 , Y10T436/24
摘要： Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of: wherein X1 is CR4 or N; and Y is selected from the group consisting of:
摘要翻译：公开了包含式A-Y的表面增强拉曼散射（SERS）报道分子及其使用方法的纳米颗粒，其中A选自：其中X 1是CR 4或N; Y选自：

6. 发明申请

US20080305489A1 NEAR-INFRARED DYES AS SURFACE ENHANCED RAMAN SCATTERING REPORTERS 有权
标题翻译：作为表面增强拉曼散射报告器的近红外线
公开(公告)号：US20080305489A1
公开(公告)日：2008-12-11
申请号：US12134594
申请日：2008-06-06
申请人： Joseph Thomas , Rajendra R. Bhat , W. Shannon Dillmore , Douglas B. Sherman
发明人： Joseph Thomas , Rajendra R. Bhat , W. Shannon Dillmore , Douglas B. Sherman
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N21/658 , A61K49/0021 , A61K49/0065 , A61K49/0093 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07D265/36 , C07D405/06 , C07D417/06 , C09B23/105 , C09B63/00 , G01N33/587 , G01N2201/06113 , Y10T428/2982 , Y10T436/24
摘要： Nanoparticles comprising surface-enhanced Raman scattering (SERS) reporter molecules of the formula A-Y and methods of their use are disclosed, wherein A is selected from the group consisting of: wherein X1 is CR4 or N; and Y is selected from the group consisting of:
摘要翻译：公开了包含式A-Y的表面增强拉曼散射（SERS）报道分子及其使用方法的纳米颗粒，其中A选自：其中X 1是CR 4或N; Y选自：

7. 发明授权

US09023661B2 Visual glucose sensor and methods of use thereof 有权
标题翻译：视觉葡萄糖传感器及其使用方法
公开(公告)号：US09023661B2
公开(公告)日：2015-05-05
申请号：US12250953
申请日：2008-10-14
申请人： Joseph Thomas , Michael T. Cash
发明人： Joseph Thomas , Michael T. Cash
IPC分类号： G01N33/533 , G01N33/53 , G01N33/542 , G01N33/66 , G01N33/92
CPC分类号： G01N33/542 , G01N33/66 , G01N33/92
摘要： A method for determining the presence or amount of one or more ligands or analytes in a sample including contacting the sample with a biosensor having an environmentally-sensitive dye conjugated to a binding member, wherein the biosensor compound exhibits a detectable color change as a result of binding to the ligand or analyte or as a result of a change in concentration of the ligand or analyte in the sample. The presently disclosed biosensors can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.
摘要翻译：一种用于确定样品中一种或多种配体或分析物的存在或量的方法，包括使样品与具有与结合成员共轭的环境敏感染料的生物传感器接触，其中生物传感器化合物由于与配体或分析物结合，或作为样品中配体或分析物的浓度变化的结果。目前公开的生物传感器可用于检测生物样品中生理重要代谢物如葡萄糖，脂肪酸和乳酸盐的存在或数量。

8. 发明授权

US08838271B2 Detection of nuclear spills using swarm optimization algorithms 有权
标题翻译：使用群优化算法检测核泄漏
公开(公告)号：US08838271B2
公开(公告)日：2014-09-16
申请号：US13390662
申请日：2010-11-29
申请人： Debasish Ghose , Joseph Thomas , Kaipa N. Krishnanand
发明人： Debasish Ghose , Joseph Thomas , Kaipa N. Krishnanand
IPC分类号： G01T7/00 , G01T1/00
CPC分类号： G01T7/00
摘要： Systems and methods are provided for localizing a radiation or chemical source utilizing a swarm of robotic devices. According to one example, a robotic device will attempt to localize a source by measuring the concentration of source particles in air, and operating in a Chemotactic state, an Anemotactic state, or a Spiraling state.
摘要翻译：提供了用于利用一群机器人设备来定位辐射或化学源的系统和方法。根据一个示例，机器人设备将尝试通过测量空气中的源粒子的浓度来定位源，并且在趋向状态，静止状态或螺旋状态下操作。

9. 发明申请

US20090311290A1 Urogenital or anorectal transmucosal vaccine delivery system 审中-公开
标题翻译：泌尿生殖或肛门直肠经粘膜疫苗递送系统
公开(公告)号：US20090311290A1
公开(公告)日：2009-12-17
申请号：US12583219
申请日：2009-08-17
申请人： Zsolt Istvan Hertelendy , Murray Weiner , Michael Howell , Joseph Thomas
发明人： Zsolt Istvan Hertelendy , Murray Weiner , Michael Howell , Joseph Thomas
IPC分类号： A61K39/245 , A61P31/22
CPC分类号： A61K9/0034 , A61K9/0031 , A61K9/02 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/541 , C12N2710/16622 , C12N2710/16634
摘要： The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a suppository based vaccine delivery system for the prophylaxis against or treatment of urogenital or anorectal transmitted infectious diseases, such as from viral or microbial pathogens. The suppository based delivery system comprises vaccine and/or vaccine adjuvant(s) comprised of whole or fractionated viral or other microbial pathogens, or their purified cellular constituents, whether native, mutated, synthetic, cloned or recombinantly expressed, that consists of nucleic acids, proteins, lipids or other antigenic determinants capable of producing humoral or cellular-mediated immunity in humans or animals; and a polyethylene glycol base; wherein the suppository is adapted to be inserted into a bodily orifice of a human or animal so as to allow the suppository to be in contact with tissue of the bodily orifice to facilitate transfer of vaccine or vaccine adjuvant(s) material therethrough.
摘要翻译：本发明涉及一种用于在人类和动物中免疫泌尿生殖和肛门直肠传播的传染病的基于栓剂的疫苗递送系统及其治疗方法。更具体地，本发明涉及一种基于栓剂的疫苗递送系统，用于预防或治疗泌尿生殖或肛门直肠传播的传染病，例如病毒或微生物病原体。基于栓剂的递送系统包括由全部或分馏的病毒或其他微生物病原体组成的疫苗和/或疫苗佐剂，或其纯化的细胞成分，无论是天然的，突变的，合成的，克隆的或重组表达的，由核酸组成，能够在人或动物中产生体液或细胞介导的免疫的蛋白质，脂质或其它抗原决定簇; 和聚乙二醇碱; 其中栓剂适于插入人或动物的身体孔中，以便使栓剂与身体孔的组织接触以促进疫苗或疫苗佐剂材料通过其传送。

10. 发明授权

US06735991B2 Tamper resistant lock assembly 失效
标题翻译：防撬锁组件
公开(公告)号：US06735991B2
公开(公告)日：2004-05-18
申请号：US10194045
申请日：2002-07-10
申请人： Alan E. Lurie , Joseph Thomas
发明人： Alan E. Lurie , Joseph Thomas
IPC分类号： E05B6544
CPC分类号： E05B17/2088 , E05B15/0205 , E05B15/10 , Y10T70/5097 , Y10T70/5102 , Y10T70/5327
摘要： A tamper resistant lock assembly is disclosed which is configured to prevent keyless operation of the lock assembly. The tamper resistant lock assembly includes a lock housing having a bolt slidably supported therein and a strike. The lock housing is secured to a mounting plate which is adapted to be fastened to a movable member such as a door. The strike is adapted to be fastened to a support member such as a door jam at a position to facilitate engagement between the bolt and the strike when the movable member is in a closed position. The strike includes a C-shaped catch member defining a recess having an opening which is configured to receive an engagement portion of the strike when the movable member is in the closed position. The engagement portion of the strike is also C-shaped and defines a recess. When the engagement portion of the presently disclosed strike is engaged by the catch member of the presently disclosed bolt, a lip portion of the bolt is positioned within the recess of the engagement portion of the strike and a lip portion of the strike is positioned within the recess of the catch member of the strike to provide an interlocking engagement which resists tampering.
摘要翻译：公开了防拆锁组件，其被配置为防止锁组件的无钥匙操作。防拆锁组件包括具有可滑动地支撑在其中的螺栓和撞击的锁壳体。锁定壳体固定到适于紧固到诸如门的可移动构件的安装板。撞击适于在可移动部件处于关闭位置时被固定到支撑部件，例如门卡在位置以便于螺栓和打击之间的接合。撞击包括限定具有开口的凹部的C形卡扣构件，该开口构造成当可动构件处于关闭位置时容纳撞击的接合部分。撞击的接合部分也是C形并且限定凹部。当目前公开的冲击的接合部分被当前公开的螺栓的卡扣构件接合时，螺栓的唇部位于撞击的接合部分的凹部内，并且撞击的唇部位于罢工构件的凹部以提供抵抗篡改的互锁接合。

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