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1. 发明申请

US20130066055A1 NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF 审中-公开
标题翻译：新的联合药物联合会（ADCS）及其使用
公开(公告)号：US20130066055A1
公开(公告)日：2013-03-14
申请号：US13451950
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
IPC分类号： C07K17/02
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译：本申请涉及针对目标C4.4a的N，N-二烷基硫酸钠的新粘合剂 - 药物共轭物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC 治疗和/或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。

2. 发明申请

US20140127240A1 Novel Binder-Drug Conjugates (ADCs) and Use of Same 审中-公开
标题翻译：新型粘合剂 - 药物共轭物（ADC）及其使用
公开(公告)号：US20140127240A1
公开(公告)日：2014-05-08
申请号：US14113070
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
IPC分类号： A61K47/48 , C07K5/06 , A61K45/06
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
摘要翻译：本专利申请涉及针对靶表皮生长因子受体（EGFR，基因ID 1956）的N，N-二烷基硫酸锡的新型粘合剂 - 药物共轭物（ADC），这些ADC的有效代谢物，制备这些ADC的方法，这些ADC用于治疗和/或预防疾病，以及使用这些ADC来制备用于治疗和/或预防疾病，特别是过度增生和/或血管发生疾病例如癌症的药物。这样的治疗可以作为单一疗法或与其它药物或其他治疗措施组合施用。

3. 发明授权

US4784441A Protective boot supporting sleeve for universal joint in wheel assembly 失效
标题翻译：保护套支撑套，用于万向节车轮组装
公开(公告)号：US4784441A
公开(公告)日：1988-11-15
申请号：US2867
申请日：1987-01-13
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： F16C19/00 , B60B27/00 , B60B35/14 , B60B35/16 , B60B35/18 , B60B27/02
CPC分类号： B60B27/0005 , Y10S464/906
摘要： In a wheel assembly for a vehicle wheel, a supportive sleeve is provided mounted in rotatably fixed engagement with a hub of the wheel assembly with one side of a protective boot for the universal joint being attached thereto. The supportive sleeve is constructed as a shaped sheet metal part shaped which, during installation, is permanently plastically deformed in press-fitted engagement with a groove in the hub of the wheel assembly and is formed with a radially extending annular region which is pressed into abutting engagement with an inner bearing ring of the wheel bearing assembly.
摘要翻译：在用于车轮的车轮组件中，提供安装成与车轮组件的轮毂可旋转地固定接合的支撑套筒，其一侧用于万向接头的保护罩。支撑套筒被构造为成形的金属片状件，其在安装期间被永久塑性地变形，与轮组件的轮毂中的槽压配合，并形成有径向延伸的环形区域，该环形区域被压入邻接与车轮轴承组件的内轴承环接合。

4. 发明授权

US4747805A Protective boot assembly for constant velocity universal joint 失效
标题翻译：恒速万向节保护罩组件
公开(公告)号：US4747805A
公开(公告)日：1988-05-31
申请号：US10398
申请日：1987-02-03
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60T8/171 , F16D3/16 , F16D3/84 , F16J3/04 , F16J15/52 , G01P3/488 , F16C1/26
CPC分类号： G01P3/488 , F16D3/845 , Y10S464/906 , Y10T403/31 , Y10T403/52
摘要： A protective boot for sealing the free space between the driving and driven parts of a constant velocity universal joint formed of a material which is suitable for injection molding, wherein the boot is formed with a larger outer diameter part mounted on an outer joint member of the joint and attached thereto by a relative thin-walled metal cap which, due to its resilience, is capable of sealingly pressing radial and axial sealing faces provided at the outer diameter part of the boot against an outer circumference and an end face of the outer joint member while securingly embracing them. The boot is formed with a smaller diameter part which is provided with an inwardly directed end facing the outer joint member and resting in sealing engagement against a driving shaft connected to an inner joint member of a universal joint over a defined distance. For improving production characteristics, the inwardly directed end of the boot may have a relatively short length and a resulting free space up to the axial limit of the joint inner member is bridged by a sleeve which may be of cardboard or plastic and which may have elongate slots to facilitate assembly.
摘要翻译：一种用于密封由适于注射成型的材料形成的等速万向接头的驱动部分和被驱动部分之间的自由空间的保护套，其中，所述护罩形成有安装在所述外部接头构件上的较大外径部分通过相对的薄壁金属盖接合并附接到其上，该金属盖由于其弹性而能够密封地将设置在护罩的外径部分处的径向和轴向密封面抵靠外部接头的外周和端面成员，同时确保拥抱他们。靴子形成有较小的直径部分，其具有面向外部接头部件的向内指向的端部，并且与限定距离上连接到万向接头的内部接头部件的驱动轴线密封接合。为了改善生产特性，靴子的向内指向的端部可以具有相对短的长度，并且通过可以是纸板或塑料的套筒桥接直到接头内部构件的轴向极限的所产生的自由空间，并且可以具有细长的槽以方便装配。

5. 发明授权

US4793212A Differential gear assembly for motor vehicles 失效
公开(公告)号：US4793212A
公开(公告)日：1988-12-27
申请号：US85456
申请日：1987-08-14
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60K17/16 , F16D3/20 , F16D3/227 , F16H48/08 , F16H48/10 , F16H1/40
CPC分类号： F16D3/227 , B60K17/165 , F16H48/08 , F16D2003/22326 , F16H2048/082 , F16H2048/085 , F16H2048/087
摘要： A differential gear assembly particularly for motor vehicles having a rotatably supported differential housing, a driving gear attached to the differential housing, at least two rotatably supported differential bevel gears and a pair of output bevel gears which engage into the differential bevel gears with a constant velocity universal joint being integrated into each of the output bevel gears. The differential bevel gears are connected in a form-fitting manner to the driving gear by means of radial and/or axial recesses, apertures or the like, with the differential housing, which may be formed of two parts, being connected to the driving gear. The differential housing is formed with an aperture or is divided in the region of each differential bevel gear to form a compact structure.

6. 发明授权

US4723464A Differential gear assembly for motor vehicles 失效
标题翻译：机动车用差速齿轮总成
公开(公告)号：US4723464A
公开(公告)日：1988-02-09
申请号：US757689
申请日：1985-07-22
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60K17/16 , F16D3/20 , F16D3/227 , F16H48/08 , F16H48/10 , F16H1/40
CPC分类号： F16D3/227 , B60K17/165 , F16H48/08 , F16D2003/22326 , F16H2048/082 , F16H2048/085 , F16H2048/087
摘要： A differential gear assembly particularly for motor vehicles having a rotatably supported differential housing, a driving gear attached to the differential housing, at least two rotatably supported differential bevel gears and a pair of output bevel gears which engage into the differential bevel gears with a constant velocity universal joint being integrated into each of the output bevel gears. The differential bevel gears are connected in a form-fitting manner to the driving gear by means of radial and/or axial recesses, apertures or the like, with the differential housing, which may be formed of two parts, being connected to the driving gear. The differential housing is formed with an aperture or is divided in the region of each differential bevel gear to form a compact structure.
摘要翻译：一种特别用于机动车辆的差速齿轮组件，其具有可旋转地支撑的差速器壳体，附接到差速器壳体的驱动齿轮，至少两个可旋转支撑的差速锥齿轮和一对输出锥齿轮，其以恒定速度接合到差速锥齿轮万向节被整合到每个输出锥齿轮中。差速器锥齿轮通过径向和/或轴向凹槽，孔或类似物以形状配合方式连接到驱动齿轮，差速器壳体可以由两部分组成，连接到驱动齿轮。差速器壳体形成有孔或者在每个差速锥齿轮的区域中分开以形成紧凑的结构。

7. 发明授权

US5499884A Hub attachment assembly 失效
标题翻译：轮毂附件总成
公开(公告)号：US5499884A
公开(公告)日：1996-03-19
申请号：US27375
申请日：1993-03-08
申请人： Wolfgang Kuhnhold , Rudolf Beier
发明人： Wolfgang Kuhnhold , Rudolf Beier
IPC分类号： F16D1/10 , F16B21/18 , F16D1/06 , F16D1/116 , B23P19/08
CPC分类号： F16D1/116 , F16B21/18 , F16D1/06 , F16D2001/103 , Y10T403/60 , Y10T403/602 , Y10T403/7033
摘要： A hub attachment assembly has a driveshaft with external splines at its shaft end, a slide-on hub with a shaft bore with corresponding internal splines, and an axial securing mechanism in the form of a resilient snap ring. The snap ring engages opposed recesses in the two sets of splines to couple the two parts together.
摘要翻译：轮毂附接组件具有在其轴端具有外花键的驱动轴，具有轴孔的滑动毂，具有相应的内部花键，以及弹性卡环形式的轴向固定机构。卡环与两组花键的相对的凹槽啮合，将两个部分连接在一起。

8. 发明授权

US5243880A Driveshaft 失效
标题翻译：传动轴
公开(公告)号：US5243880A
公开(公告)日：1993-09-14
申请号：US676096
申请日：1991-03-27
申请人： Rudolf Beier , Peter Amborn , Wolfgang Exner , Herbert Frielingsdorf , Klaus Greulich , Joachim Altdorf , Ivan Rericha
发明人： Rudolf Beier , Peter Amborn , Wolfgang Exner , Herbert Frielingsdorf , Klaus Greulich , Joachim Altdorf , Ivan Rericha
IPC分类号： B60K17/30 , B60K17/22 , F16C3/02
CPC分类号： F16C3/02 , B60K17/22 , Y10T464/50 , Y10T74/2188
摘要： A driveshaft for a motor vehicle has an approximately constant wall thickness and a changing outer diameter which extends analogously to the amplitude of the second basic vibration of the natural bending frequency. In this way it is possible to achieve a distribution of cross-sectional area which is functionally optimized and meets the respective strength requirements. At the same time, torsional stiffness values may be set as required and natural resonance frequency values may be varied. With help of this design it is possible to move the natural resonance frequency of the tubular shaft into a speed range of minimum external excitation energy.
摘要翻译：用于机动车辆的驱动轴具有近似恒定的壁厚和改变的外径，其类似于自然弯曲频率的第二基本振动的振幅延伸。以这种方式，可以实现功能优化并满足相应强度要求的横截面积的分布。同时，可以根据需要设定扭转刚度值，并且可以改变固有谐振频率值。在这种设计的帮助下，可以将管状轴的固有共振频率移动到最小外部激发能量的速度范围内。

9. 发明授权

US5052979A Shaft assembly for the wheel drive of a motor vehicle 失效
标题翻译：用于电动车辆的车轮驱动的轴组件
公开(公告)号：US5052979A
公开(公告)日：1991-10-01
申请号：US28015
申请日：1987-03-18
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： F16C3/02 , B60B27/00 , B60K17/30 , F16D3/20
CPC分类号： B60B27/0005 , F16C19/184 , F16C2326/02 , F16C35/0635 , Y10S464/906
摘要： A wheel drive shaft assembly for a motor vehicle including two universal joints, at least one of which is a plunging joint to enable axial movement of the shaft assembly, with one of the universal joints further including a splined journal engaging into a wheel hub, wherein the axial length of the splined journal is smaller than the amount of axial shortening available in the shaft assembly by virtue of the plunging movement of the at least one plunging universal joint when the shaft assembly is built into the motor vehicle.
摘要翻译：一种用于机动车辆的轮驱动轴组件，其包括两个万向接头，其中至少一个是用于使轴组件轴向运动的突出接头，其中一个万向接头还包括接合到轮毂的花键轴颈，其中当轴组件安装在机动车辆中时，花键轴颈的轴向长度小于轴组件中可用的轴向起酥油量，这是由于至少一个插入万向接头的插入运动。

10. 发明授权

US4893960A Wheel Bearing/constant velocity joint unit 失效
标题翻译：车轮轴承/等速万向节单元
公开(公告)号：US4893960A
公开(公告)日：1990-01-16
申请号：US113008
申请日：1987-10-26
申请人： Rudolf Beier , Hans-Heinrich Welschof
发明人： Rudolf Beier , Hans-Heinrich Welschof
IPC分类号： F16C19/18 , B60B27/00 , B60B35/14 , B60B35/18 , F16C43/04 , F16D1/076 , F16D3/20 , F16D3/223 , F16D3/2237
CPC分类号： B60B27/0005 , F16C19/184 , F16C33/586 , F16C43/04 , F16D1/076 , F16D3/2237 , F16C2326/02 , F16D2003/22326 , Y10T403/18 , Y10T403/4688 , Y10T403/49 , Y10T403/7092
摘要： The invention relates to a wheel bearing/constant velocity joint unit having a double row bearing 2 which has been provided with at least one inner bearing ring 12 which is separate from the wheel hub 1. The wheel hub and the outer part of the constant velocity joint are form-fittingly and non-rotatingly connected to each other by spur teeth. The spur teeth at the wheel hub are preferably produced by orbital pressing or orbital forging, and while the forming process takes place a collar is produced at the wheel hub which serves for axially tensioning the inner bearing rings, at least the one of the joint end.
摘要翻译：本发明涉及一种具有双列轴承2的车轮轴承/等速万向节单元，双列轴承2设置有至少一个与轮毂1分离的内轴承环12.轮毂和恒速的外部部分接头通过正齿形态配合和非旋转地相互连接。轮毂上的正齿齿优选地通过轨道压制或轨道锻造产生，并且在成形过程发生时，在轮毂处产生一个轴环，用于轴向张紧内轴承环，至少一个接合端。

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