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1. 发明授权

US07771357B2 Devices and methods for occlusion of the uterine arteries 失效
标题翻译：用于闭塞子宫动脉的装置和方法
公开(公告)号：US07771357B2
公开(公告)日：2010-08-10
申请号：US10459342
申请日：2003-06-10
申请人： Fred Burbank , Michael Jones , Paul Lubock
发明人： Fred Burbank , Michael Jones , Paul Lubock
IPC分类号： A61B8/00 , A61B5/05 , A61B17/08
CPC分类号： A61B8/12 , A61B8/06 , A61B8/0833 , A61B17/12013 , A61B17/42 , A61B18/1485
摘要： Devices and methods are disclosed for treating a uterine disorder which receive its blood supply from a uterine artery. In particular, uterine fibroids are effectively treated by occluding the uterine arteries using trans-vaginal, trans-uterine, transrectal, or retroperitoneal approaches. The devices and methods are advantageous because the inventive procedures may be performed by a patient's gynecologist in the course of treatment, avoiding the need for referrals to specialist practitioners and for more radical treatments, such as hysterectomies. The methods include both temporary and permanent occlusion of the arteries. A cannula carries an imaging device and a member which will easily penetrate tissue, the member including a device which partially or completely, and temporarily or permanently, occludes a uterine artery.
摘要翻译：公开了用于治疗从子宫动脉接受其血液供应的子宫疾病的装置和方法。特别地，子宫肌瘤通过使用经阴道，经子宫，经直肠或腹膜后方法闭塞子宫动脉来有效治疗。所述装置和方法是有利的，因为本发明的方法可以由患者的妇科医生在治疗过程中进行，避免需要转诊给专科医师，以及进行诸如子宫切除术等更激进的治疗。这些方法包括动脉的临时和永久闭塞。套管携带成像装置和容易穿透组织的构件，该构件包括部分地或完全地暂时地或永久地阻塞子宫动脉的装置。

2. 发明申请

US20060155190A1 Imageable biopsy site marker 审中-公开
标题翻译：可成像的活检部位标记
公开(公告)号：US20060155190A1
公开(公告)日：2006-07-13
申请号：US11366956
申请日：2006-03-02
申请人： Fred Burbank , Paul Lubock , Michael Jones , Nancy Forcier
发明人： Fred Burbank , Paul Lubock , Michael Jones , Nancy Forcier
IPC分类号： A61B6/00
CPC分类号： A61B90/39 , A61B10/02 , A61B2017/00004 , A61B2090/3788 , A61B2090/3908 , A61B2090/3925 , A61B2090/3929 , A61B2090/3933 , A61B2090/395 , A61B2090/3975 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61M37/0069
摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by an delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.
摘要翻译：活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。具有不透射线物体的至少一个生物可再吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。将管的一端放入活检部位。至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像导入后的第二时间点（如5-7个月）附近的组织组织。

3. 发明申请

US20060094983A1 Methods and apparatus for securing medical instruments to desired locations in a patient's body 审中-公开
公开(公告)号：US20060094983A1
公开(公告)日：2006-05-04
申请号：US11303154
申请日：2005-12-15
申请人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
发明人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
IPC分类号： A61B10/00 , A61M5/178
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2090/3908 , A61B2090/3987 , A61B2090/3991
摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

4. 发明申请

US20050063908A1 Tissue site markers for in vivo imaging 有权
标题翻译：用于体内成像的组织位点标记
公开(公告)号：US20050063908A1
公开(公告)日：2005-03-24
申请号：US10658911
申请日：2003-09-10
申请人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick , Frank Louw , Stephen De Santis
发明人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick , Frank Louw , Stephen De Santis
IPC分类号： A61B6/00 , A61B6/12 , A61B8/08 , A61B10/00 , A61B10/02 , A61B17/00 , A61B19/00 , A61K49/00 , A61K49/04 , A61K49/22
CPC分类号： A61M37/0069 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/08021 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
摘要翻译：本发明涉及活检部位标记和标记活组织检查部位的方法，使得活检腔的位置通过常规成像方法，特别是通过超声成像容易看到。本发明的活检部位标记物具有高的超声反射率，从小标记物呈现出实质的声学特征，以避免在随后的成像研究中掩盖诊断组织特征，并且可以容易地与生物特征区别开来。本发明的活检部位标记物的几个公开的实施方案具有放置在组织部位中的声阻抗的高对比度，以便有效地反射和散射超声能量，并且优选地包括气体填充的内部孔。标记可以具有不均匀的表面轮廓以增强声学特征。标记具有在医学成像期间可识别人造的特征形式。可以将活检部位标记物精确地固定到活检部位，以便当放置放置器械被取出时以及随后移动或操纵标记的组织时抵抗活组织腔的迁移。

5. 发明申请

US20050010131A1 Breast biopsy system and methods 审中-公开
公开(公告)号：US20050010131A1
公开(公告)日：2005-01-13
申请号：US10913747
申请日：2004-08-06
申请人： Fred Burbank , Michael Jones , Paul Lubock
发明人： Fred Burbank , Michael Jones , Paul Lubock
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.

6. 发明申请

US20050187490A1 Breast biopsy system and methods 审中-公开
公开(公告)号：US20050187490A1
公开(公告)日：2005-08-25
申请号：US11111659
申请日：2005-04-21
申请人： Fred Burbank , Michael Jones , Paul Lubock
发明人： Fred Burbank , Michael Jones , Paul Lubock
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.

7. 发明申请

US20050143674A1 Methods and apparatus for securing medical instruments to desired locations in a patient's body 有权
公开(公告)号：US20050143674A1
公开(公告)日：2005-06-30
申请号：US11059992
申请日：2005-02-17
申请人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
发明人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00 , A61F2/82
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2019/5487 , A61B2019/5491 , A61B2090/3908 , A61B2090/3991
摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

8. 发明申请

US20050187491A1 Breast biopsy system and methods 审中-公开
标题翻译：乳腺活检系统及方法
公开(公告)号：US20050187491A1
公开(公告)日：2005-08-25
申请号：US11112894
申请日：2005-04-22
申请人： Fred Burbank , Michael Jones , Paul Lubock
发明人： Fred Burbank , Michael Jones , Paul Lubock
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.
摘要翻译：提供了一种用于精确地分离患者体内组织中的靶病变的装置和方法，导致当其被去除用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅使用单一经皮手术来诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术，同时最小化可能的癌细胞从病变迁移到周围的风险组织或血液。特别地，该装置包括具有适于进入患者身体的远端的活检器械，纵向轴和沿轴设置的切割元件。切割元件可在径向缩回位置和径向延伸位置之间致动。有利地，仪器可以在其径向延伸位置中绕其轴线旋转，以通过围绕组织样本限定周边边界来将期望的组织样本与周围组织隔离。一旦组织样本被分离，则可以通过进一步操纵切割元件来分割组织样本，之后组织片段优选通过套管等从患者身体单独地移除。或者，样品可以作为完整的片段被包封和去除。

9. 发明申请

US20050143656A1 Cavity-filling biopsy site markers 有权
公开(公告)号：US20050143656A1
公开(公告)日：2005-06-30
申请号：US10990327
申请日：2004-11-16
申请人： Fred Burbank , Paul Lubock , Michael Jones
发明人： Fred Burbank , Paul Lubock , Michael Jones
IPC分类号： A61B6/00 , A61B6/12 , A61B8/08 , A61B8/12 , A61B10/00 , A61B10/02 , A61B17/00 , A61B19/00 , A61K49/00 , A61K49/04 , A61K49/22 , A61B8/14
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

10. 发明申请

US20050090762A1 Electrosurgical biopsy device and method 有权
标题翻译：电外科活检装置及方法
公开(公告)号：US20050090762A1
公开(公告)日：2005-04-28
申请号：US10650027
申请日：2003-08-27
申请人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
发明人： Fred Burbank , Paul Lubock , Michael Jones , Richard Quick
IPC分类号： A61B10/02 , A61B1/00 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2010/0208 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An electrosurgical biopsy device includes a stylet and a cannula movably mounted on a base. The stylet has a shaft with a head at its distal end and a stylet ablation element extending distally from the head. The stylet shaft is disposed through the cannula for axial translation therein between withdrawn and extended positions. The cannula has an opening at its distal end and a tissue cutting element adjacent the opening. Both ablation elements are activatable with energy that ablates adjacent tissue. A translation mechanism controllably moves (a) the stylet between the withdrawn and extended positions end (b) the cannula between a proximal position and a distal position relative to the base.
摘要翻译：电外科活检装置包括探针和可移动地安装在基座上的套管。探针具有在其远端具有头部的轴和从头部向远侧延伸的探针消融元件。探针轴穿过套管设置，用于在撤回位置和伸出位置之间进行轴向平移。套管在其远端具有开口，并且与开口相邻的组织切割元件。两种消融元件都可以通过消融相邻组织的能量来激活。平移机构可以可控地移动（a）在缩回位置和延伸位置之间的探针（b）插管在相对于基座的近端位置和远端位置之间移动。

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