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1. 发明授权

US08241665B2 Chewable soft capsule 有权
标题翻译：咀嚼软胶囊
公开(公告)号：US08241665B2
公开(公告)日：2012-08-14
申请号：US13270005
申请日：2011-10-10
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48 , A61K9/64
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
摘要翻译：提供了一种用于软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。还提供了咀嚼软胶囊，具有增强的有机光和加工性能。可以使用该剂型将活性物质递送给使用者。还提供了形成可咀嚼软胶囊的方法。

2. 发明授权

US06521243B2 Ionic chitosan -iodine complexes: antiseptic hydrogels and wound healing promoters 有权
标题翻译：离子壳聚糖 - 碘复合物：消毒水凝胶和伤口愈合促进剂
公开(公告)号：US06521243B2
公开(公告)日：2003-02-18
申请号：US09748335
申请日：2000-12-22
申请人： EmadEldin M. Hassan
发明人： EmadEldin M. Hassan
IPC分类号： A01N2534
CPC分类号： A61K33/18 , A61K47/61 , A61K31/715 , A61K2300/00
摘要： This invention describes non-staining, pharmaceutically useful compositions of ionic complexes made between the cationic polymer chitosan or its derivatives and the small anionic iodine-iodide complex (ICIC's). Unlike previously disclosed ion transfer chitosan iodine complexes, ICIC's were found to possess dramatically higher viscosity than those of each ingredient separately, and instantly form a gel structure that is easily dispersible upon shaking. In addition to their antiseptic power, ICIC's showed better skin biocompatibility than povidone iodine and effectively promoted wound healing.
摘要翻译：本发明描述了在阳离子聚合物壳聚糖或其衍生物和小型阴离子碘碘化物络合物（ICIC's）之间制备的离子络合物的非染色，药学上有用的组合物。与以前公开的离子转移壳聚糖碘络合物不同，发现ICIC具有比每种成分分别高得多的粘度，并立即形成在振动时容易分散的凝胶结构。除了防腐功能外，ICIC显示出比聚维酮碘更好的皮肤生物相容性，有效促进伤口愈合。

3. 发明授权

US08765174B2 Chewable soft capsule 有权
标题翻译：咀嚼软胶囊
公开(公告)号：US08765174B2
公开(公告)日：2014-07-01
申请号：US13327293
申请日：2011-12-15
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
摘要翻译：提供了一种用于软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。还提供了咀嚼软胶囊，具有增强的有机光和加工性能。可以使用该剂型将活性物质递送给使用者。还提供了形成可咀嚼软胶囊的方法。

4. 发明授权

US08414916B2 Chewable soft capsule 有权
标题翻译：咀嚼软胶囊
公开(公告)号：US08414916B2
公开(公告)日：2013-04-09
申请号：US13491670
申请日：2012-06-08
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48 , A61K9/64
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
摘要翻译：提供了一种用于软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。还提供了咀嚼软胶囊，具有增强的有机光和加工性能。可以使用该剂型将活性物质递送给使用者。还提供了形成可咀嚼软胶囊的方法。

5. 发明申请

US20110052679A1 SOLID NAPROXEN CONCENTRATES AND RELATED DOSAGE FORMS 审中-公开
标题翻译：固体纳豆浓度和相关剂量形式
公开(公告)号：US20110052679A1
公开(公告)日：2011-03-03
申请号：US12547329
申请日：2009-08-25
申请人： EmadEldin M. Hassan , Sridhar Gumudavelli
发明人： EmadEldin M. Hassan , Sridhar Gumudavelli
IPC分类号： A61K9/48 , A61K31/192 , A61P29/00
CPC分类号： A61K9/4833 , A61K9/1617 , A61K9/1688 , A61K9/4866 , A61K31/192
摘要： The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.
摘要翻译：本发明提供了一种基本上由固体萘普生浓缩物组成的组合物，其中固体萘普生浓缩物包含（a）固体萘普生游离酸和（b）固体萘普生碱盐，并且其中至少90％的固体萘普生浓缩物是萘普生游离酸和萘普生碱盐，以及生产这种固体萘普生浓缩物的方法。

6. 发明申请

US20120091605A1 Chewable Soft Capsule 有权
公开(公告)号：US20120091605A1
公开(公告)日：2012-04-19
申请号：US13327293
申请日：2011-12-15
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.

7. 发明授权

US06623761B2 Method of making nanoparticles of substantially water insoluble materials 有权
标题翻译：制备基本上水不溶性材料的纳米颗粒的方法
公开(公告)号：US06623761B2
公开(公告)日：2003-09-23
申请号：US09748803
申请日：2000-12-22
申请人： EmadEldin M. Hassan
发明人： EmadEldin M. Hassan
IPC分类号： A61K914
CPC分类号： A61K31/568 , A61K9/14 , A61K31/192 , A61K31/519 , A61K31/57 , Y10S514/951
摘要： This invention relates to a novel process of manufacture of nanoparticles of substantially water insoluble materials from emulsions. The emulsions have the ability to form a single liquid phase upon dilution of the external phase, instantly producing dispersible solid nanoparticles. The formed nanoparticles have average diameter of about 10 to 200 nm and are suitable for drug delivery and targeting of water insoluble therapeutic or diagnostic agents. Examples of such agents are methotrexate, progesterone, testosterone, prednisolone, and ibuprofen. Such agents can be used in a wide range of therapeutic and diagnostic treatments including treatment for cancer, hormonal therapy, and pain management.
摘要翻译：本发明涉及从乳液制造基本上不溶于水的材料的纳米颗粒的新方法。该乳液能够在外相稀释时形成单一液相，立即产生可分散的固体纳米颗粒。形成的纳米颗粒具有约10至200nm的平均直径，并且适用于药物递送和水不溶性治疗剂或诊断剂的靶向。这些试剂的实例是甲氨蝶呤，孕酮，睾酮，泼尼松龙和布洛芬。这些药物可用于广泛的治疗和诊断治疗，包括治疗癌症，激素治疗和疼痛治疗。

8. 发明申请

US20120258169A1 Chewable Soft Capsule 有权
标题翻译：咀嚼软胶囊
公开(公告)号：US20120258169A1
公开(公告)日：2012-10-11
申请号：US13491670
申请日：2012-06-08
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48 , A61P37/08 , A61P11/12 , A61P11/06 , A61P29/00 , A61P25/08 , A61P31/00
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
摘要翻译：提供了一种用于软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。还提供了咀嚼软胶囊，具有增强的有机光和加工性能。可以使用该剂型将活性物质递送给使用者。还提供了形成可咀嚼软胶囊的方法。

9. 发明申请

US20120034298A1 Chewable Soft Capsule 有权
公开(公告)号：US20120034298A1
公开(公告)日：2012-02-09
申请号：US13270005
申请日：2011-10-10
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/48 , A61P37/08 , A61P11/02 , A61P25/08 , A61P31/00 , A61P25/04 , A61P11/06
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.

10. 发明授权

US08097279B2 Chewable soft capsule 有权
标题翻译：咀嚼软胶囊
公开(公告)号：US08097279B2
公开(公告)日：2012-01-17
申请号：US10512318
申请日：2003-04-24
申请人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
发明人： EmadEldin M. Hassan , Warren W. Kindt , Roger E. Gordon
IPC分类号： A61K9/64
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
摘要翻译：提供了一种软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。还提供了咀嚼软胶囊，具有增强的有机光和加工性能。可以使用该剂型将活性物质递送给使用者。还提供了形成可咀嚼软胶囊的方法。

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