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1. 发明授权

US6102917A Shape memory polymer (SMP) gripper with a release sensing system 失效
标题翻译：形状记忆聚合物（SMP）夹具与释放感应系统
公开(公告)号：US6102917A
公开(公告)日：2000-08-15
申请号：US116019
申请日：1998-07-15
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Luiz Da Silva
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Luiz Da Silva
IPC分类号： B25J7/00 , A61B17/00 , A61B17/12 , A61B17/28 , A61B19/00 , B81B7/02 , A61F11/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00022 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/1205 , A61B2017/12072
摘要： A system for releasing a target material, such as an embolic coil from an SMP located at the end of a catheter utilizing an optical arrangement for releasing the material. The system includes a laser, laser driver, display panel, photodetector, fiber optics coupler, fiber optics and connectors, a catheter, and an SMP-based gripper, and includes a release sensing and feedback arrangement. The SMP-based gripper is heated via laser light through an optic fiber causing the gripper to release a target material (e.g., embolic coil for therapeutic treatment of aneurysms). Various embodiments are provided for coupling the laser light into the SMP, which includes specific positioning of the coils, removal of the fiber cladding adjacent the coil, a metal coating on the SMP, doping the SMP with a gradient absorbing dye, tapering the fiber optic end, coating the SMP with low refractive index material, and locating an insert between the fiber optic and the coil.
摘要翻译：一种用于从位于导管端部的SMP释放目标材料（例如栓塞线圈）的系统，其利用用于释放材料的光学装置。该系统包括激光，激光驱动器，显示面板，光电检测器，光纤耦合器，光纤和连接器，导管和基于SMP的夹持器，并且包括释放感测和反馈装置。基于SMP的夹持器通过光纤通过光纤被加热，使得夹具释放靶材料（例如用于治疗动脉瘤的栓塞线圈）。提供了用于将激光耦合到SMP中的各种实施例，其包括线圈的特定定位，邻近线圈的光纤包层的移除，SMP上的金属涂层，用梯度吸收染料掺杂SMP，使光纤以低折射率材料涂覆SMP，并将插入物定位在光纤和线圈之间。

2. 发明授权

US6059815A Microfabricated therapeutic actuators and release mechanisms therefor 失效
标题翻译：微型治疗执行器及其释放机制
公开(公告)号：US6059815A
公开(公告)日：2000-05-09
申请号：US67824
申请日：1998-04-28
申请人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
发明人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
IPC分类号： A61B17/00 , A61B17/12 , A61M25/16 , A61B17/28
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00867 , A61B2017/00871 , A61B2017/12068 , A61B2017/12077
摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a retaining/release actuator for the delivery of material, such as embolic coils, for example, through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use. The SMP microtubing can be positioned around or within an end of a deposit material. Various heating arrangements can be utilized with the SMP release mechanism, and the SMP microtubing can include a metallic coating for enhanced light absorption.
摘要翻译：使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。通过使用这种SMP材料，SMP微管可用作用于例如通过导管穿入动脉瘤等物质输送的保持/释放致动器。微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。 SMP微管可以定位在沉积材料的周围或内部。 SMP释放机构可以使用各种加热装置，并且SMP微管可以包括用于增强光吸收的金属涂层。

3. 发明授权

US06740094B2 Shape memory polymer actuator and catheter 有权
公开(公告)号：US06740094B2
公开(公告)日：2004-05-25
申请号：US09761023
申请日：2001-01-16
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
IPC分类号： A61F1100
CPC分类号： A61B17/32075 , A61B17/22031 , A61B17/221 , A61B17/320725 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/320064 , A61M25/0158 , A61M2025/0064
摘要： An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.

4. 发明授权

US07291154B2 Shape memory polymer actuator and catheter 有权
标题翻译：形状记忆聚合物致动器和导管
公开(公告)号：US07291154B2
公开(公告)日：2007-11-06
申请号：US10713622
申请日：2003-11-13
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
IPC分类号： A61F11/00
CPC分类号： A61B17/32075 , A61B17/22031 , A61B17/221 , A61B17/320725 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/320064 , A61M25/0158 , A61M2025/0064
摘要： An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.
摘要翻译：提供用于作用在容器中的材料的致动器系统。该系统包括可操作地连接到光纤的光纤和形状记忆聚合物材料。形状记忆聚合物材料适于从用于移动通过所述容器的第一形状移动到其可以作用在所述材料上的第二形状。

5. 发明授权

US08882786B2 System for closure of a physical anomaly 有权
标题翻译：关闭物理异常的系统
公开(公告)号：US08882786B2
公开(公告)日：2014-11-11
申请号：US10781582
申请日：2004-02-17
申请人： Jane P. Bearinger , Duncan J. Maitland , Daniel L. Schumann , Thomas S. Wilson
发明人： Jane P. Bearinger , Duncan J. Maitland , Daniel L. Schumann , Thomas S. Wilson
IPC分类号： A61B17/08 , A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00867 , A61B2017/00871
摘要： Systems for closure of a physical anomaly. Closure is accomplished by a closure body with an exterior surface. The exterior surface contacts the opening of the anomaly and closes the anomaly. The closure body has a primary shape for closing the anomaly and a secondary shape for being positioned in the physical anomaly. The closure body preferably comprises a shape memory polymer.
摘要翻译：关闭物理异常的系统。封闭通过具有外表面的封闭体实现。外表面接触异常开口并关闭异常。闭合体具有用于闭合异常的主要形状和用于定位在物理异常中的次级形状。封闭体优选地包括形状记忆聚合物。

6. 发明授权

US06240630B1 Apparatus for loading shape memory gripper mechanisms 失效
标题翻译：装载形状记忆夹持机构的装置
公开(公告)号：US06240630B1
公开(公告)日：2001-06-05
申请号：US08984624
申请日：1997-12-03
申请人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
发明人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
IPC分类号： B21D3904
CPC分类号： A61B17/221 , A61B17/1219 , A61B2017/00345 , A61B2017/00867 , A61B2017/00871 , A61B2017/1205 , A61B2017/12068 , A61B2017/12072 , Y10T29/49865 , Y10T29/49929 , Y10T29/53439 , Y10T29/53987
摘要： A method and apparatus for loading deposit material, such as an embolic coil, into a shape memory polymer (SMP) gripping/release mechanism. The apparatus enables the application of uniform pressure to secure a grip by the SMP mechanism on the deposit material via differential pressure between, for example, vacuum within the SMP mechanism and hydrostatic water pressure on the exterior of the SMP mechanism. The SMP tubing material of the mechanism is heated to above the glass transformation temperature (Tg) while reshaping, and subsequently cooled to below Tg to freeze the shape. The heating and/or cooling may, for example, be provided by the same water applied for pressurization or the heating can be applied by optical fibers packaged to the SMP mechanism for directing a laser beam, for example, thereunto. At a point of use, the deposit material is released from the SMP mechanism by reheating the SMP material to above the temperature Tg whereby it returns to its initial shape. The reheating of the SM material may be carried out by injecting heated fluid (water) through an associated catheter or by optical fibers and an associated beam of laser light, for example.
摘要翻译：一种用于将诸如栓塞线圈的沉积材料装载到形状记忆聚合物（SMP）夹持/释放机构中的方法和装置。该装置能够通过例如SMP机构中的真空和SMP机构的外部上的静水压力之间的压差来施加均匀的压力，以通过SMP机构来确保在沉积材料上的握持。将机构的SMP管材料加热至高于玻璃化转变温度（Tg），同时重塑，随后冷却至Tg以下以冻结形状。加热和/或冷却可以例如由施加加压的相同的水提供，或者可以通过包封在SMP机构中的光纤施加加热，以引导例如激光束。在使用时，通过将SMP材料再加热到高于Tg的温度Tg，沉积材料从SMP机制释放，由此其恢复到初始形状。 SM材料的再加热可以通过例如通过相关联的导管或通过光纤和相关的激光束注入加热的流体（水）来进行。

7. 发明授权

US06370757B1 Method for loading shape memory polymer gripper mechanisms 有权
公开(公告)号：US06370757B1
公开(公告)日：2002-04-16
申请号：US09568615
申请日：2000-05-10
申请人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
发明人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
IPC分类号： B23P1102
摘要： A method and apparatus for loading deposit material, such as an embolic coil, into a shape memory polymer (SMP) gripping/release mechanism. The apparatus enables the application of uniform pressure to secure a grip by the SMP mechanism on the deposit material via differential pressure between, for example, vacuum within the SMP mechanism and hydrostatic water pressure on the exterior of the SMP mechanism. The SMP tubing material of the mechanism is heated to above the glass transformation temperature (Tg) while reshaping, and subsequently cooled to below Tg to freeze the shape. The heating and/or cooling may, for example, be provided by the same water applied for pressurization or the heating can be applied by optical fibers packaged to the SMP mechanism for directing a laser beam, for example, thereunto. At a point of use, the deposit material is released from the SMP mechanism by reheating the SMP material to above the temperature Tg whereby it returns to its initial shape. The reheating of the SMP material may be carried out by injecting heated fluid (water) through an associated catheter or by optical fibers and an associated beam of laser light, for example.

8. 发明申请

US20100010437A1 STEERABLE CATHETER WITH DISTENDING LUMEN-ACTUATED CURLING CATHETER TIP 审中-公开
标题翻译：可拆卸的导管，带有开启式开关式导流管
公开(公告)号：US20100010437A1
公开(公告)日：2010-01-14
申请号：US12502097
申请日：2009-07-13
申请人： Robin R. Miles , Daniel L. Schumann , Mark A. Pearson , Dawn Hilken
发明人： Robin R. Miles , Daniel L. Schumann , Mark A. Pearson , Dawn Hilken
IPC分类号： A61M25/092
CPC分类号： A61M25/0158 , A61M25/0155
摘要： A steerable catheter having a catheter tip connected to an elongated catheter body, with the catheter tip having an elastomeric cylindrical body and one or more steering lumens each offset from the longitudinal axis of the elastomeric cylindrical body and extending substantially the length of the elastomeric cylindrical body so that increasing the internal pressure of one or more of the steering lumens using, for example, a pneumatic or hydraulic pressure source or heating a thermally expandable media in the steering lumens, operates to curl the longitudinal axis of the elastomeric cylindrical body towards the internally pressurized steering lumen or lumens for steering the catheter tip.
摘要翻译：导管的导管，其具有连接到细长导管主体的导管尖端，其中导管尖端具有弹性体圆柱形主体和一个或多个转向腔，其各自偏离弹性体圆柱形主体的纵向轴线并基本延伸弹性体圆柱体的长度使得使用例如气动或液压压力源或加热转向腔内的热膨胀介质来增加一个或多个转向腔的内部压力，以使弹性体圆柱体的纵向轴线向内部弯曲用于转向导管尖端的加压转向腔或腔。

9. 发明授权

US07744604B2 Shape memory polymer medical device 有权
标题翻译：形状记忆聚合物医疗器械
公开(公告)号：US07744604B2
公开(公告)日：2010-06-29
申请号：US11172668
申请日：2005-06-30
申请人： Duncan Maitland , William J. Benett , Jane P. Bearinger , Thomas S. Wilson , Ward Small, IV , Daniel L. Schumann , Wayne A. Jensen , Jason M. Ortega , John E. Marion, III , Jeffrey M. Loge
发明人： Duncan Maitland , William J. Benett , Jane P. Bearinger , Thomas S. Wilson , Ward Small, IV , Daniel L. Schumann , Wayne A. Jensen , Jason M. Ortega , John E. Marion, III , Jeffrey M. Loge
IPC分类号： A61F11/00
CPC分类号： A61B17/221 , A61B2017/00867 , A61B2017/22034 , A61B2017/2215 , A61B2017/2217
摘要： A system for removing matter from a conduit. The system includes the steps of passing a transport vehicle and a shape memory polymer material through the conduit, transmitting energy to the shape memory polymer material for moving the shape memory polymer material from a first shape to a second and different shape, and withdrawing the transport vehicle and the shape memory polymer material through the conduit carrying the matter.
摘要翻译：用于从管道中去除物质的系统。该系统包括将运输车辆和形状记忆聚合物材料通过导管的步骤，将能量传递到形状记忆聚合物材料，以将形状记忆聚合物材料从第一形状移动到第二形状和不同形状，并且将运送车辆和形状记忆聚合物材料通过导管携带物质。

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