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1. 发明申请

US20130078282A1 FORMULATIONS DECREASING PARTICLE EXHALATION 有权
公开(公告)号：US20130078282A1
公开(公告)日：2013-03-28
申请号：US13455585
申请日：2012-04-25
申请人： David A. Edwards , Jonathan C. Man , Jeffrey P. Katstra , Robert W. Clarke
发明人： David A. Edwards , Jonathan C. Man , Jeffrey P. Katstra , Robert W. Clarke
IPC分类号： A61K9/16 , A61M15/00 , A61K9/14
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

2. 发明授权

US08187637B2 Formulations decreasing particle exhalation 有权
标题翻译：减少颗粒呼气的配方
公开(公告)号：US08187637B2
公开(公告)日：2012-05-29
申请号：US11714999
申请日：2007-03-06
申请人： David A. Edwards , Jonathan C. Man , Jeffrey P. Katstra , Robert W. Clarke
发明人： David A. Edwards , Jonathan C. Man , Jeffrey P. Katstra , Robert W. Clarke
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K9/12 , A61K9/14
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

3. 发明授权

US08591866B2 Formulations decreasing particle exhalation 有权
标题翻译：减少颗粒呼气的配方
公开(公告)号：US08591866B2
公开(公告)日：2013-11-26
申请号：US13455585
申请日：2012-04-25
申请人： David A. Edwards , Jonathan Chun-Wah Man , Jeffrey P. Katstra , Robert W. Clarke
发明人： David A. Edwards , Jonathan Chun-Wah Man , Jeffrey P. Katstra , Robert W. Clarke
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

4. 发明申请

US20120107414A1 PHARMACEUTICAL FORMULATIONS AND METHODS FOR TREATING RESPIRATORY TRACT INFECTIONS 审中-公开
标题翻译：药物制剂和治疗呼吸道感染的方法
公开(公告)号：US20120107414A1
公开(公告)日：2012-05-03
申请号：US13259651
申请日：2010-03-26
申请人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
发明人： Michael M. Lipp , Robert W. Clarke , David L. Hava , Richard Batycky , John Hanrahan
IPC分类号： A61K33/42 , A61K33/10 , A61K33/06 , A61K33/00 , A61K33/04 , A61K33/22 , A61K31/19 , A61K31/734 , A61K31/20 , A61K31/191 , A61K31/194 , A61K31/375 , A61K31/192 , A61P31/00 , A61K33/14
CPC分类号： A61K31/19 , A61K9/0078 , A61K31/194 , A61K31/20 , A61K31/734 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/10 , A61K33/14 , A61K33/42 , A61K45/06 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Ca+2 to Na+ is from about 4:1 (mole:mole) to about 16:1 (mole:mole). The invention also relates to methods of treating (including prophylactically treating) and reducing the spread of a respiratory tract infection, methods of treating (including prophylactically treating) a pulmonary disease or an acute exacerbation of a pulmonary disease, and methods of reducing the spread of an acute exacerbation of a pulmonary disease, comprising administering a pharmaceutical formulation that comprises a calcium salt and a sodium salt.
摘要翻译：本发明涉及用于治疗个体中的呼吸道感染或肺部疾病的药物制剂，其包含钙盐和钠盐，其中Ca + 2与Na +的比例为约4:1（摩尔：摩尔）至约16：1（摩尔：摩尔）。本发明还涉及治疗（包括预防性治疗）和减少呼吸道感染扩散的方法，治疗（包括预防性治疗）肺部疾病或肺部疾病急性加重的方法，以及减少是肺疾病的急性恶化，包括施用包含钙盐和钠盐的药物制剂。

5. 发明申请

US20120070417A1 ANTI-INFLUENZA FORMULATIONS AND METHODS 审中-公开
标题翻译：抗流感制剂和方法
公开(公告)号：US20120070417A1
公开(公告)日：2012-03-22
申请号：US13259659
申请日：2010-03-26
申请人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
发明人： Richard Batycky , David L. Hava , Robert W. Clarke , Michal M. Lipp
IPC分类号： A61K33/14 , A61K38/21 , A61K31/19 , A61K31/715 , A61P31/16 , A61K31/7105 , A61K31/351 , A61K31/195 , A61K31/245 , A61K38/47 , A61K31/713
CPC分类号： A61K47/183 , A61K9/0075 , A61K9/0078 , A61K9/1617 , A61K9/1694 , A61K31/125 , A61K31/155 , A61K31/196 , A61K31/454 , A61K33/06 , A61K33/14 , A61K45/06 , A61K2300/00
摘要： The invention relates to pharmaceutical compositions that contain a calcium salt as an active ingredient and also comprise another anti-influenza agent, and to methods for treating or preventing influenza virus infection.
摘要翻译：本发明涉及含有钙盐作为活性成分并且还包含另一种抗流感药物的药物组合物，以及用于治疗或预防流感病毒感染的方法。

6. 发明申请

US20130281361A1 METHODS OF TREATING AND PREVENTING RHINOVIRUS INFECTION 审中-公开
标题翻译：治疗和预防恶病毒感染的方法
公开(公告)号：US20130281361A1
公开(公告)日：2013-10-24
申请号：US13883912
申请日：2011-11-04
申请人： David L. Hava , Robert W. Clarke
发明人： David L. Hava , Robert W. Clarke
IPC分类号： A61K38/17
CPC分类号： A61K38/1729 , A61K38/17
摘要： The present invention relates to methods of treating or preventing non-enveloped viral infection and/or disease caused by non-enveloped virus infection, particularly a viral infection caused by rhino virus. The methods comprise administering to an individual in need thereof an effective amount of a defensin peptide. The defensin peptide may be selected from α-, β-, or θ-defensins.
摘要翻译：本发明涉及治疗或预防由非包膜病毒感染引起的非包膜病毒感染和/或疾病的方法，特别是由犀病毒引起的病毒感染。所述方法包括向有需要的个体施用有效量的防御素肽。防御素肽可以选自α-，β-或θ-防御素。

7. 发明申请

US20110190096A1 Stretching Apparatus 审中-公开
标题翻译：拉伸装置
公开(公告)号：US20110190096A1
公开(公告)日：2011-08-04
申请号：US12997656
申请日：2009-06-12
申请人： Robert W. Clarke
发明人： Robert W. Clarke
IPC分类号： A63B21/00
CPC分类号： A61H1/0274 , A61H1/0237 , A61H1/0292 , A61H2203/0437 , A63B21/00178 , A63B23/0211 , A63B23/0233 , A63B23/03575 , A63B23/04 , A63B23/085 , A63B2023/006 , A63B2208/0238 , A63B2225/09
摘要： The invention relates to a stretching apparatus which is used to stretch the posterior muscles and tendons by means of powered stretching movements. The apparatus comprises a body (102), a seat area (101) a moveable handle grip (111) and foot pedals (105). In use grips (111) are moved forward whilst the user keeps his or her legs straight. That movement stretches some of the posterior muscles (including the back and buttock muscles). Further movement of the foot pedals 105 toward the user stretches his or her upper and lower leg muscles. The stretching movements could be mechanical, e.g. spring or worm screw actuated, or other power could be used. Electronic control (120) of the apparatus is described.
摘要翻译：本发明涉及一种拉伸装置，其用于通过动力拉伸运动来拉伸后肌肉和肌腱。该装置包括主体（102），座位区域（101），可移动手柄把手（111）和脚踏板（105）。使用手柄（111）向前移动，同时使用者将他或她的双腿保持直线。该运动延伸一些后部肌肉（包括背部和臀部肌肉）。脚踏板105向使用者的进一步运动使他或她的上肢和小腿肌肉伸展。拉伸运动可以是机械的。可以使用弹簧或蜗杆螺杆，或者可以使用其他动力。描述该装置的电子控制（120）。

8. 发明授权

US4284217A Ball carrier 失效
标题翻译：球载体
公开(公告)号：US4284217A
公开(公告)日：1981-08-18
申请号：US114116
申请日：1980-01-21
申请人： James J. Johnston , Robert W. Clarke
发明人： James J. Johnston , Robert W. Clarke
IPC分类号： B62J11/00
CPC分类号： B62J11/00 , Y10S224/919
摘要： An inflatable ball is carried on a bicycle by a carrying device which has a holder releasably engaging the bicycle handlebar and a stem projecting from the holder into the valve of the ball and grippingly engaging a wall of the valve within the interior of the ball.
摘要翻译：充气球由携带装置承载在自行车上，所述运送装置具有可释放地接合自行车车把的保持器和从保持器突出到球的阀中的杆，并且在球内部夹紧地接合阀的壁。

9. 发明申请

US20120058198A1 METHODS FOR TREATING AND PREVENTING PNEUMONIA AND VENTILATOR-ASSOCIATED TRACHEOBRONCHITIS 审中-公开
标题翻译：治疗和预防肺炎和呼吸道相关TRACHEOBRONCHITIS的方法
公开(公告)号：US20120058198A1
公开(公告)日：2012-03-08
申请号：US13259615
申请日：2010-03-26
申请人： Robert W. Clarke , Richard Batycky , Wesley H. Dehaan , David L. Hava , Michael M. Lipp , John Hanrahan
发明人： Robert W. Clarke , Richard Batycky , Wesley H. Dehaan , David L. Hava , Michael M. Lipp , John Hanrahan
IPC分类号： A61P31/04 , A61K33/06 , A61K33/14
CPC分类号： A61K33/06 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K33/14 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The invention relates to methods for treating bacterial infection of the respiratory tract, including pneumonias, such as ventilator-associated pneumonia, and to methods for treating ventilator-associated tracheobronchitis, comprising administering an effective amount of a salt formulation as an aerosol to the respiratory tract of an individual in need thereof. The formulations can also be used to reduce transmission of pathogen which can infect the respiratory tract, cause pneumonia or cause ventilator-associated tracheobronchitis.
摘要翻译：本发明涉及治疗呼吸道细菌感染的方法，包括呼吸机相关性肺炎等肺炎，以及治疗与呼吸机相关的气管支气管炎的方法，包括向呼吸道施用有效量的作为气雾剂的盐制剂的需要的个人。制剂也可用于减少可感染呼吸道，引起肺炎或引起呼吸机相关气管支气管炎的病原体的传播。

10. 发明申请

US20130213398A1 DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES 有权
公开(公告)号：US20130213398A1
公开(公告)日：2013-08-22
申请号：US13817963
申请日：2011-08-26
申请人： Michael M. Lipp , Jean C. Sung , Robert W. Clarke , David L. Hava
发明人： Michael M. Lipp , Jean C. Sung , Robert W. Clarke , David L. Hava
IPC分类号： A61K47/02 , A61M15/00
CPC分类号： A61K47/02 , A61K9/0073 , A61K9/0075 , A61K31/137 , A61K31/198 , A61K33/06 , A61K33/14 , A61K47/12 , A61K47/183 , A61K2300/00 , A61M15/00 , B22F3/1125 , B22F5/10 , C22C21/00
摘要： The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection.

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