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1. 发明申请

WO2007130647A2 ACTUATION OF PARALLEL MICROFLUIDIC ARRAYS 审中-公开
标题翻译：平行微流体阵列的启动
公开(公告)号：WO2007130647A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010959
申请日：2007-05-04
申请人： CYTONOME, INC. , JOHNSON, Andrew , GILBERT, John, R. , DESHPANDE, Manish , LEWIS, Hugh , BUNNER, Bernard
发明人： JOHNSON, Andrew , GILBERT, John, R. , DESHPANDE, Manish , LEWIS, Hugh , BUNNER, Bernard
CPC分类号： B07C5/34 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , C12M47/04
摘要： An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
摘要翻译：用于微流体粒子分选系统的改进的致动器利用交错填充方案用于多个致动器，用于选择性地偏转相关分拣通道中的粒子与通道流。可以提供致动器块，用于容纳致动器的二维阵列，每个致动器阵列被配置为与包含多个分选通道的相关分选芯片中的致动端口对齐。致动器块可以包括内置的应力装置，用于预加载由该块所容纳的每个致动器。包括压电叠层的致动器可以使用基于接触的电连接而不是焊接线来改善堆积密度。致动器可以是外部致动器。也就是说，外部致动器在其中形成分拣通道的基板的外部。

2. 发明申请

WO2005042137A2 MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE 审中-公开
标题翻译：多层水动力流动结构
公开(公告)号：WO2005042137A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036548
申请日：2004-11-01
申请人： CYTONOME, INC. , GILBERT, John, R. , DESHPANDE, Manish , BUNNER, Bernard
发明人： GILBERT, John, R. , DESHPANDE, Manish , BUNNER, Bernard
IPC分类号： B01F
CPC分类号： B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a to selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译：用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道，用于将样品注入主鞘流道中的鞘液中的样品入口，用于将样品聚焦在护套流体和辅助聚焦区域，用于提供样品在护套液体内的附加聚焦。次要聚焦区域可以由与主鞘流道相交的流动通道形成，以将附加的护套流体从一个选定的方向注入主鞘流动通道。护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。

3. 发明申请

WO2006060783A2 UNITARY CARTRIDGE FOR PARTICLE PROCESSING 审中-公开
标题翻译：颗粒加工单位盒
公开(公告)号：WO2006060783A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/043965
申请日：2005-12-05
申请人： CYTONOME, INC. , GILBERT, John, R. , LEWIS, Hugh , BEAUPRE, Derek , DESHPANDE, Manish , TRIKHA, Jaishree
发明人： GILBERT, John, R. , LEWIS, Hugh , BEAUPRE, Derek , DESHPANDE, Manish , TRIKHA, Jaishree
IPC分类号： G01N15/00 , B01L3/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在粒子上执行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

4. 发明申请

WO2005017969A2 OPTICAL DETECTOR FOR A PARTICLE SORTING SYSTEM 审中-公开
标题翻译：用于颗粒分选系统的光学检测器
公开(公告)号：WO2005017969A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/026467
申请日：2004-08-16
申请人： CYTONOME, INC. , GILBERT, John, R. , SINOFSKY, Ed. , DESHPANDE, Manish
发明人： GILBERT, John, R. , SINOFSKY, Ed. , DESHPANDE, Manish
IPC分类号： H01L
CPC分类号： G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6452 , G01N2015/1081
摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.
摘要翻译：用于从空间通道阵列获取快速光谱的光学系统包括用于产生穿过微流体芯片或待监测通道的光束的光源，用于在相互作用之后捕获来自光源的光的一个或多个透镜或光纤微流体通道中的颗粒或化学物质，以及一个或多个检测器。可以包括光放大元件的检测器检测每个光信号并将光信号转换成电子信号。每个表示光信号强度的电子信号从每个检测器传递到电子数据采集系统进行分析。光放大元件可以包括耦合到光电二极管检测器阵列的光管阵列，多子光电管或基于多通道板的图像增强器。

5. 发明申请

WO2004087281A2 IMPLEMENTATION OF MICROFLUIDIC COMPONENTS, INCLUDING MOLECULAR FRACTIONATION DEVICES, IN A MICROFLUIDIC SYSTEM 审中-公开
标题翻译：在微流体系统中实现微流体组分，包括分子分馏装置
公开(公告)号：WO2004087281A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/010163
申请日：2004-03-31
申请人： CYTONOME, INC. , GILBERT, John, R. , DESHPANDE, Manish , TRIKHA, Jaishree
发明人： GILBERT, John, R. , DESHPANDE, Manish , TRIKHA, Jaishree
IPC分类号： B01D
CPC分类号： G01N30/84 , B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2300/0681 , B01L2300/0887 , B01L2400/0421 , G01N30/02 , G01N30/6095 , G01N30/80 , G01N2030/8411 , B01D15/3804
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
摘要翻译：用于将微流体组件集成在微流体系统中的系统和方法使微流体系统能够执行选定的微流体功能。封盖模块包括用于执行微流体功能的微流体元件。加盖模块堆叠在具有微流体管道的微流体基底上以将微流体功能并入系统中。微流体元件可以包含对样品中的选定分子具有亲和力的基质。基质结合，与选定的分子反应和/或保留，而不影响样品中的其他分子。

6. 发明申请

WO2005031163A1 IMPLEMENTATION OF MICROFLUIDIC COMPONENTS IN A MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流控系统中微流控元件的实现
公开(公告)号：WO2005031163A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/031818
申请日：2004-09-27
申请人： CYTONOME, INC. , GILBERT, John, R. , DESHPANDE, Manish
发明人： GILBERT, John, R. , DESHPANDE, Manish
IPC分类号： F04B17/00
CPC分类号： F04B43/043 , F04B43/02
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.
摘要翻译：用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。封盖模块包括用于执行微流控功能的微流体元件。封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。用于从流体源输送流体的输液泵可以使用其中形成有泵送部件的封盖模块集成在微流体芯片中。

7. 发明申请

WO2003043042A1 MEMS DEVICE HAVING ELECTROTHERMAL ACTUATION AND RELEASE AND METHOD FOR FABRICATING 审中-公开
标题翻译：具有电热启动和释放的MEMS器件和用于制造的方法
公开(公告)号：WO2003043042A1
公开(公告)日：2003-05-22
申请号：PCT/US2002/035923
申请日：2002-11-08
申请人： COVENTOR, INCORPORATED , CUNNINGHAM, Shawn, J. , DEREUS, Dana, R. , SETT, Subham , GILBERT, John, R.
发明人： CUNNINGHAM, Shawn, J. , DEREUS, Dana, R. , SETT, Subham , GILBERT, John, R.
IPC分类号： H01H37/52
CPC分类号： B81B3/0024 , B81B3/0051 , B81B2201/014 , B81B2201/018 , B81B2203/0118 , B81B2203/04 , B81B2207/07 , B81C1/0015 , B81C2201/0107 , B81C2201/0108 , B81C2201/0109 , H01H1/04 , H01H1/504 , H01H59/0009 , H01H61/04 , H01H2001/0042 , H01H2001/0063 , H01H2001/0089 , H01H2059/0072 , H01H2061/006 , H01L23/3735 , H01L23/522 , H01L27/1203 , H01L2924/0002 , H01L2924/09701 , H02N1/006 , H02N10/00 , Y10T29/49222 , H01L2924/00
摘要： MEMS device (100) having an electrothermal actuator (126) and release and a method for fabrication. According to one embodiment, a microscale switch (100) is provided and can include a substrate (102) and a stationary electrode (106) and stationary contact (104) formed on the substrate (102). The switch (100) can further include a movable microcomponent (108) suspended above the substrate (102). The microcomponent (108) can include a structural layer (112) including at least one end fixed with respect to the substrate (102). The microcomponent (108) can further include a movable electrode (118) spaced from the stationary electrode (106). The microcomponent (108) can include an electrothermal component (126) attached to the structural layer (112) and operable to produce heating for generating force for moving the structural layer (112).
摘要翻译：具有电热致动器126和释放的MEMS装置100和制造方法。根据一个实施例，提供微型开关100，并且可以包括衬底102和形成在衬底102上的固定电极106和固定触点104.开关100还可以包括悬浮在衬底102上方的可移动的微元件108.微组件 108可以包括包括相对于衬底102固定的至少一个端部的结构层112.微组件108还可以包括与固定电极106间隔开的可移动电极118.微组件108可以包括附接到结构的电热部件126 层112并且可操作以产生用于产生用于移动结构层112的力的加热。

8. 发明申请

WO2009011808A1 DROPLET-BASED SELECTION 审中-公开
标题翻译：基于DROPLET的选择
公开(公告)号：WO2009011808A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/008563
申请日：2008-07-11
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WEITZ, David, A. , GRIFFITHS, Andrew , KOESTER, Sarah , MOOTHA, Vamsi, K. , DUAN, Honey , AGRESTI, Jeremy , MERTEN, Christoph , HEYMAN, John , GILBERT, John, R.
发明人： WEITZ, David, A. , GRIFFITHS, Andrew , KOESTER, Sarah , MOOTHA, Vamsi, K. , DUAN, Honey , AGRESTI, Jeremy , MERTEN, Christoph , HEYMAN, John , GILBERT, John, R.
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： G01N33/505 , B01F13/0071 , B01F13/0076 , B01L3/502784 , G01N15/1459 , G01N33/5052 , G01N33/5436 , G01N33/6854 , G01N2015/149
摘要： The present invention generally relates to fluidic droplets, and techniques for screening or sorting such fluidic droplets. In some embodiments, the fluidic droplets may contain cells (e.g., hybridoma cells) that can secrete various species, such as antibodies, for example. In one aspect, a plurality of fluidic droplets containing cells is screened to determine proteins, antibodies, polypeptides, peptides, nucleic acids, or the like. For example, cells able to secrete species such as antibodies may be selected according to certain embodiments of the invention. Examples of such cells include, for instance, immortal cells such as hybridomas, or non-immortal cells such as B-cells. For instance, blood cells may be encapsulated within a plurality of fluidic droplets, and the cells able to produce antibodies may be determined. In some cases, expression or secretion levels may be determined using signaling entities, for example, determinable microparticles present within the fluidic droplet. Other aspects of the invention relate to kits involving such fluidic droplets, methods of promoting the making or use of such fluidic droplets, and the like.
摘要翻译：本发明一般涉及流体液滴，以及用于筛选或分类这种流体液滴的技术。在一些实施方案中，流体液滴可以含有可分泌各种物质例如抗体的细胞（例如，杂交瘤细胞）。在一个方面，筛选含有细胞的多个流体液滴以确定蛋白质，抗体，多肽，肽，核酸等。例如，可以根据本发明的某些实施方案来选择能够分泌诸如抗体的物质的细胞。这些细胞的实例包括，例如，诸如杂交瘤的永生细胞，或非永生细胞如B细胞。例如，血细胞可以被包封在多个流体液滴中，并且可以确定能产生抗体的细胞。在一些情况下，表达或分泌水平可以使用信号实体来确定，例如存在于流体液滴内的可测定的微粒。本发明的其它方面涉及涉及这种流体液滴的试剂盒，促进制造或使用这种流体液滴的方法等。

9. 发明申请

WO2004055935A1 VARACTOR APPARATUSES AND METHODS 审中-公开
标题翻译：变压器装置和方法
公开(公告)号：WO2004055935A1
公开(公告)日：2004-07-01
申请号：PCT/US2003/039806
申请日：2003-12-15
申请人： WISPRY, INC. , MUSALEM, Francois-Xavier , BOUWSTRA, Siebe , GILBERT, John, R. , MORRIS, Arthur, S., III , RICHARDS, Randy, J.
发明人： MUSALEM, Francois-Xavier , BOUWSTRA, Siebe , GILBERT, John, R. , MORRIS, Arthur, S., III , RICHARDS, Randy, J.
IPC分类号： H01P1/10
CPC分类号： H01G5/16 , H01G5/04 , H01G5/08 , H01G5/10 , H01G5/18 , H01G5/38 , H01P1/127
摘要： Micro-electro-mechanical system (MEMS) variable capacitor apparatuses, system and related methods are provided.
摘要翻译：提供微机电系统（MEMS）可变电容器装置，系统及相关方法。

10. 发明申请

WO2004023106A1 MICROFLUIDIC CHIP FOR BIOMOLECULE CRYSTALLIZATION 审中-公开
标题翻译：用于生物分子结晶的微流控芯片
公开(公告)号：WO2004023106A1
公开(公告)日：2004-03-18
申请号：PCT/US2003/028513
申请日：2003-09-09
申请人： CYTONOME, INC.
发明人： GILBERT, John, R. , TRIKHA, Jaishree
IPC分类号： G01N1/00
CPC分类号： B01D61/243 , B01D61/28 , B01D63/087 , B01D63/088 , B01L3/06 , B01L3/5027 , B01L2300/0681 , C30B7/00 , C30B29/58
摘要： A system for crystallizing a protein and other biomolecules, the general scheme of which is represented in Figure 1, comprises a flow channel (12) for conveying a solution containing the biomolecule to be crystallized and one or more substations (40, 50, 60, 70) related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through the flow channel (12), then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译：用于结晶蛋白质和其它生物分子的系统（其一般方案如图1所示）包括用于输送含有待结晶的生物分子的溶液的流动通道（12）和一个或多个变电站（40,50,60， 70）与沿着流动通道形成的结晶过程相关。该系统通过使生物分子溶液流过流动通道（12），然后在微量级上进行透析以设定结晶条件来操作。透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。可以从流动通道观察并收获形成的晶体。

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