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1. 发明授权

US5688518A Antidepressive therapy 失效
标题翻译：抗抑郁药
公开(公告)号：US5688518A
公开(公告)日：1997-11-18
申请号：US507890
申请日：1995-07-27
申请人： Atul Devdatt Ayer , Dana Ridzon
发明人： Atul Devdatt Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K9/52 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K9/24
CPC分类号： A61K9/0004 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

2. 发明授权

US5246711A Dosage form for treating dysthymia 失效
标题翻译：用于治疗心境恶劣的剂型
公开(公告)号：US5246711A
公开(公告)日：1993-09-21
申请号：US943618
申请日：1992-09-10
申请人： Atul D. Ayer , Dana Ridzon
发明人： Atul D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K31/495 , A61K31/496 , A61K31/505
CPC分类号： A61K31/505 , A61K31/495 , A61K31/496 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

3. 发明申请

US20060078906A1 Methods, compositions, and kits comprising linker probes for quantifying polynucleotides 有权
公开(公告)号：US20060078906A1
公开(公告)日：2006-04-13
申请号：US11142720
申请日：2005-05-31
申请人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Lao , Neil Straus
发明人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Lao , Neil Straus
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6876 , C07H21/04 , C12N9/00 , C12P19/34 , C12Q1/686 , C12Q2525/301 , C12Q2600/16 , C12Q2600/178
摘要： The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.

4. 发明授权

US5185158A Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same 失效
标题翻译：包含用于治疗抑郁障碍的琥珀酰亚胺药物的剂型及包含其的组合物
公开(公告)号：US5185158A
公开(公告)日：1993-02-09
申请号：US842682
申请日：1992-02-27
申请人： Atul; D. Ayer , Dana Ridzon
发明人： Atul; D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K9/52 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506
CPC分类号： A61K31/506 , A61K31/495 , A61K31/496 , A61K31/505 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

5. 发明授权

US09068222B2 Methods compositions, and kits comprising linker probes for quantifying polynucleotides 有权
标题翻译：方法组合物和包含用于定量多核苷酸的连接探针的试剂盒
公开(公告)号：US09068222B2
公开(公告)日：2015-06-30
申请号：US12543466
申请日：2009-08-18
申请人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
发明人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
IPC分类号： C07H21/04 , C12N9/00 , C12Q1/68
CPC分类号： C12Q1/6876 , C07H21/04 , C12N9/00 , C12P19/34 , C12Q1/686 , C12Q2525/301 , C12Q2600/16 , C12Q2600/178
摘要： The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.
摘要翻译：本发明涉及用于鉴定和定量靶多核苷酸序列的方法，试剂，试剂盒和组合物。包含3'靶特异性部分，环和茎的接头探针与目标多核苷酸杂交并延伸以形成包含反向引物部分和茎核苷酸的反应产物。可以在扩增反应中使用检测器探针，特异性正向引物和反向引物，其中检测器探针可以基于由接头探针引入的干核苷酸检测扩增的靶多核苷酸。在一些实施方案中，使用多个接头探针查询多个短miRNA，其中所述连接物探针都包含不同3'靶特异性部分和不同茎的通用反向引物部分。然后可以在多个扩增反应中解码多个查询的miRNA。

6. 发明授权

US5330762A Tandospiaine antidepressive therapy 失效
标题翻译：坦度螺酮抗抑郁药治疗
公开(公告)号：US5330762A
公开(公告)日：1994-07-19
申请号：US10086
申请日：1993-01-27
申请人： Atul D. Ayer , Dana Ridzon
发明人： Atul D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K9/52 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K47/34 , A61P25/20 , A61P25/24 , A61P25/26 , A61K9/24
CPC分类号： A61K31/496 , A61K31/495 , A61K31/505 , A61K31/506 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

7. 发明申请

US20130011840A1 Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides 审中-公开
标题翻译：包含用于定量多核苷酸的接头探针的方法，组合物和试剂盒
公开(公告)号：US20130011840A1
公开(公告)日：2013-01-10
申请号：US13612485
申请日：2012-09-12
申请人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
发明人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C07H21/04 , C12N9/00 , C12P19/34 , C12Q1/686 , C12Q2525/301 , C12Q2600/16 , C12Q2600/178
摘要： The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.
摘要翻译：本发明涉及用于鉴定和定量靶多核苷酸序列的方法，试剂，试剂盒和组合物。包含3'靶特异性部分，环和茎的接头探针与目标多核苷酸杂交并延伸以形成包含反向引物部分和茎核苷酸的反应产物。可以在扩增反应中使用检测器探针，特异性正向引物和反向引物，其中检测器探针可以基于由接头探针引入的干核苷酸检测扩增的靶多核苷酸。在一些实施方案中，使用多个接头探针查询多个短miRNA，其中所述连接物探针都包含不同3'靶特异性部分和不同茎的通用反向引物部分。然后可以在多个扩增反应中解码多个查询的miRNA。

8. 发明申请

US20100112573A1 Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides 有权
标题翻译：包含用于定量多核苷酸的接头探针的方法，组合物和试剂盒
公开(公告)号：US20100112573A1
公开(公告)日：2010-05-06
申请号：US12543466
申请日：2009-08-18
申请人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
发明人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Qin Lao , Neil A. Straus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C07H21/04 , C12N9/00 , C12P19/34 , C12Q1/686 , C12Q2525/301 , C12Q2600/16 , C12Q2600/178
摘要： The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.
摘要翻译：本发明涉及用于鉴定和定量靶多核苷酸序列的方法，试剂，试剂盒和组合物。包含3'靶特异性部分，环和茎的接头探针与目标多核苷酸杂交并延伸以形成包含反向引物部分和茎核苷酸的反应产物。可以在扩增反应中使用检测器探针，特异性正向引物和反向引物，其中检测器探针可以基于由接头探针引入的干核苷酸检测扩增的靶多核苷酸。在一些实施方案中，使用多个接头探针查询多个短miRNA，其中所述连接物探针都包含不同3'靶特异性部分和不同茎的通用反向引物部分。然后可以在多个扩增反应中解码多个查询的miRNA。

9. 发明授权

US5246710A Dosage form for treating cyclothymia 失效
标题翻译：用于治疗环状胸腺的剂型
公开(公告)号：US5246710A
公开(公告)日：1993-09-21
申请号：US942899
申请日：1992-09-10
申请人： Atul D. Ayer , Dana Ridzon
发明人： Atul D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K31/495 , A61K31/496 , A61K31/505
CPC分类号： A61K31/505 , A61K31/495 , A61K31/496 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

10. 发明授权

US07601495B2 Methods, compositions, and kits comprising linker probes for quantifying polynucleotides 有权
标题翻译：包含用于定量多核苷酸的连接探针的方法，组合物和试剂盒
公开(公告)号：US07601495B2
公开(公告)日：2009-10-13
申请号：US11142720
申请日：2005-05-31
申请人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Q. Lao , Neil A. Straus
发明人： Caifu Chen , Dana Ridzon , Zhaohui Zhou , Kai Q. Lao , Neil A. Straus
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6876 , C07H21/04 , C12N9/00 , C12P19/34 , C12Q1/686 , C12Q2525/301 , C12Q2600/16 , C12Q2600/178
摘要： The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions.
摘要翻译：本发明涉及用于鉴定和定量靶多核苷酸序列的方法，试剂，试剂盒和组合物。包含3'靶特异性部分，环和茎的接头探针与目标多核苷酸杂交并延伸以形成包含反向引物部分和茎核苷酸的反应产物。可以在扩增反应中使用检测器探针，特异性正向引物和反向引物，其中检测器探针可以基于由接头探针引入的干核苷酸检测扩增的靶多核苷酸。在一些实施方案中，使用多个接头探针查询多个短miRNA，其中所述连接物探针都包含不同3'靶特异性部分和不同茎的通用反向引物部分。然后可以在多个扩增反应中解码多个查询的miRNA。

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