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1. 发明申请

US20100187837A1 ACTUATION DEVICE FOR A COVER OF A BODY OPENING OF A MOTOR VEHICLE 审中-公开
标题翻译：用于电动车辆开启的盖子的启动装置
公开(公告)号：US20100187837A1
公开(公告)日：2010-07-29
申请号：US12529880
申请日：2007-11-17
申请人： Andreas Danner , Bernd Winkler , Norbert Mayer , Stephan Meyer
发明人： Andreas Danner , Bernd Winkler , Norbert Mayer , Stephan Meyer
IPC分类号： E05C1/12
CPC分类号： E05C19/022 , B60K15/05 , E05B83/34 , E05F1/105 , E05Y2900/534 , Y10T292/097
摘要： An actuation device (1) for a cover of a body opening of a motor vehicle has a locking pin (5) guided axially in a housing (3), and a control device (11) for controlling an opening range of the locking pin (5). The control device (11) is disposed laterally next to the locking pin (5) and kinematically connected to the locking pin (5).
摘要翻译：一种用于机动车辆的车体开口的盖的致动装置（1）具有在壳体（3）中轴向引导的锁定销（5），以及用于控制锁定销的开口范围的控制装置（11） 5）。控制装置（11）横向放置在锁定销（5）的旁边并运动地连接到锁定销（5）。

2. 发明授权

US5179090A Condensed diazepinones and medicaments containing these compounds 失效
标题翻译：浓缩二氮杂酮和含有这些化合物的药物
公开(公告)号：US5179090A
公开(公告)日：1993-01-12
申请号：US779203
申请日：1991-10-18
申请人： Klaus Rudolf , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gerhard Mihm , Henri Doods , Norbert Mayer
发明人： Klaus Rudolf , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gerhard Mihm , Henri Doods , Norbert Mayer
IPC分类号： C07D487/18 , C07D519/00
CPC分类号： C07D487/18 , C07D519/00
摘要： Condensed diazepinones of general formula I ##STR1## in which]B represents one of the divalent groups ##STR2## X is a .dbd.CH-- group or a nitrogen atom,R represents a lower alkyl radical, which may optionally be further substituted by a phenyl optionally carrying halogen, methyl or methoxy,R.sup.4 and R.sup.5 represent hydrogen, halogen or lower alkyl,R.sup.6 is hydrogen, chlorine or methyl,R.sup.7 and R.sup.8 denote lower alkyl, R.sup.8 also additionally denotes halogen, andm, n, o and p represent the numbers 0, 1, 2 or 3 with the following limitations: the sum of m+n and the sum of o+p each denote the numbers 1, 2 or 3, the sum of n+o and the sum of m+p each denote the numbers 1, 2, 3, 4 or 5, wherein, however, the sum of m+n+o+p must always be greater than 2, andA.sup.1, A.sup.2, A.sup.3 and A.sup.4 denote hydrogen, or, for the case where m, n, o and p each denote the number 1, A.sup.1 and A.sup.2 together or A.sup.3 and A.sup.4 together represent an ethylene bridge,are suitable for the treatment of cholinergically induced spasms and motility disorders of the gastrointestinal tract and in the region of the evacuating bile ducts, for the symptomatic treatment of cystitis and of spasms from urelithiasis, for the treatment of relative incontinence, for the symptomatic treatment of bronchial asthma and bronchitis, and for the treatment of ischaemic heart diseases. The compounds are characterized by good selectivity.
摘要翻译：（I）其中] + E，crc / B /表示二价基团之一的通式I的缩二氮杂酮类（I）其中一个二价基团（S）（T） V）X是= CH-基或氮原子，R表示低级烷基，其可以任选地被任选地带有卤素，甲基或甲氧基的苯基进一步取代，R4和R5代表氢，卤素或低级烷基，R6 是氢，氯或甲基，R7和R8表示低级烷基，R8还另外表示卤素，m，n，o和p表示数字0,1,2或3，具有以下限制：m + n和 o + p的和表示数字1,2或3，n + o和m + p之和各自表示数字1,2,3,4或5，其中，然而， m + n + o + p必须始终大于2，A1，A2，A3和A4表示氢，或者对于m，n，o和p分别表示数字1，A1和A2一起或A3 和A4一起代表乙烯桥，适合于处理o f胆碱能诱发胃肠道的痉挛和运动障碍以及排空胆管区域，用于膀胱炎和尿毒症痉挛的症状治疗，用于治疗相对失禁，用于支气管哮喘和支气管炎的症状治疗，并用于治疗缺血性心脏病。该化合物的特征在于良好的选择性。

3. 发明授权

US5011836A Agents for the treatment of acute and chronic obstructive respiratory passage diseases 失效
标题翻译：用于治疗急性和慢性阻塞性呼吸道疾病的药剂
公开(公告)号：US5011836A
公开(公告)日：1991-04-30
申请号：US438827
申请日：1989-11-17
申请人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Henri Doods , Norbert Mayer
发明人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Henri Doods , Norbert Mayer
IPC分类号： C07D223/20 , A61K31/55 , A61P11/00 , C07D401/12
CPC分类号： A61K31/55 , Y10S514/826
摘要： A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]azepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-one, alone or in combination.
摘要翻译：一种治疗阻塞性呼吸道传播障碍的方法，其包括使用5,11-二氢-11 - [[（1-甲基-4-哌啶基） - 氨基]羰基] -6H-二苯并[b，e]氮杂- 一; 5,11-二氢-11 - [（1-甲基-4-哌嗪基）乙酰基] -6H-二苯并[b，e]氮杂-6-酮，5,11-二氢-11 - [（4-甲基-1- - 哌嗪基）乙酰基] -6H-二苯并[b，e]氮杂-6-酮，单独或组合使用。

4. 发明授权

US5002943A Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds 失效
标题翻译：浓缩二氮杂酮，其制备方法和含有这些化合物的药物组合物
公开(公告)号：US5002943A
公开(公告)日：1991-03-26
申请号：US366828
申请日：1989-06-15
申请人： Gerhard Mihm , Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Norbert Mayer , Adrian de Jonge , Henri Doods
发明人： Gerhard Mihm , Wolfgang Eberlein , Wolfhard Engel , Gunter Trummlitz , Norbert Mayer , Adrian de Jonge , Henri Doods
IPC分类号： A61K31/00 , A61K31/55 , A61K31/551 , A61P1/00 , A61P9/04 , A61P9/06 , A61P11/00 , A61P13/02 , A61P15/00 , C07D243/14 , C07D403/12 , C07D471/04 , C07D471/14 , C07D495/04
CPC分类号： C07D403/12 , C07D471/04 , C07D471/14 , C07D495/04
摘要： Novel condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, A.sup.1, A.sup.2 and R.sup.1 -R.sup.10 are as defined herein. The condensed diazepinones are suitable as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia and they have spasmolytic effects on peripheral organs, particularly the colon, bladder and bronchi.
摘要翻译：新的通式I的缩合二氮杂酮其中B表示二价基团之一，其中X，A1，A2和R1-R10如本文所定义。浓缩的二氮嗪酮适合作为迷走神经起搏器用于治疗心动过缓和缓慢性心律失常，并且对周围器官特别是结肠，膀胱和支气管具有解痉作用。

5. 发明授权

US4650915A Process for preparing p-chlorotoluene and/or m-chlorotoluene 失效
标题翻译：制备对氯甲苯和/或间氯甲苯的方法
公开(公告)号：US4650915A
公开(公告)日：1987-03-17
申请号：US764511
申请日：1985-08-09
申请人： Hans-Jurgen Arpe , Heinz Litterer , Norbert Mayer
发明人： Hans-Jurgen Arpe , Heinz Litterer , Norbert Mayer
IPC分类号： B01J20/18 , B01J23/00 , B01J29/08 , B01J29/18 , B01J29/40 , B01J29/70 , C07B61/00 , C07C17/00 , C07C17/12 , C07C17/358 , C07C17/38 , C07C17/389 , C07C17/395 , C07C25/02 , C07C67/00
CPC分类号： C07C25/02 , C07C17/358 , C07C17/389
摘要： The invention relates to a process for preparing p-chlorotoluene and/or m-chlorotoluene by ring-chlorination of toluene by using the following two pages (a) and (b) when further processing the toluene chlorination product composed of mixed isomers:(a) Isolation of p-chlorotoluene from a mixture of o-, m- and p-chlorotoluene by selective adsorption of p-chlorotoluene onto a mesoporous or macroporous zeolite and subsequent desorption of p-chlorotoluene(b) Treatment of an o-chlorotoluene-rich mixture of isomers with an isomerization catalyst.For the exclusive preparation of p-chlorotoluene first p-chlorotoluene is isolated and removed from the toluene chlorination product in stage (a). The remaining mixed isomers are then treated in stage (b) to increase their content of m- and p-isomers and then returned into stage (a).For the preparation of m-chlorotoluene and, if appropriate, additionally of p-chlorotoluene first the toluene chlorination product is treated in stage (b) to increase its content of m- and, if appropriate, p-isomer. p-Chlorotoluene is then isolated in stage (a) and returned to stage (b), or, if appropriate, removed. The remaining mixture essentially comprising o- and m-isomers is separated by distillation or adsorption and o-chlorotoluene is then returned into stage (b) and m-chlorotoluene is removed.
摘要翻译：本发明涉及通过使用以下两页（a）和（b）进一步处理由混合异构体组成的甲苯氯化产物时，通过甲苯的环氯化来制备对氯甲苯和/或间氯甲苯的方法：（a ）通过将对氯甲苯选择性吸附到介孔或大孔沸石上并随后对对氯甲苯的解吸，从邻 - ，间 - 和对 - 氯甲苯的混合物中分离对氯甲苯（b）处理富含邻氯甲苯异构体与异构化催化剂的混合物。对于专门制备对氯甲苯，首先在阶段（a）中从甲苯氯化产物中分离并除去对氯甲苯。然后在阶段（b）中处理剩余的混合异构体以增加它们的m-和p-异构体的含量，然后返回到阶段（a）。为了制备间氯甲苯，并且如果合适，另外还加入对氯甲苯，在步骤（b）中处理甲苯氯化产物，以增加其含量，如果合适，增加对异构体。然后在阶段（a）中分离出对 - 氯甲苯并返回到阶段（b），或者如果合适的话除去。通过蒸馏或吸附分离基本上含有O-和m-异构体的剩余混合物，然后将邻氯甲苯回到步骤（b）中，并除去间氯甲苯。

6. 发明授权

US4168260A N-substituted triaza-adamantanyl ureas as stabilizers for thermoplastic materials 失效
标题翻译： N-取代的三氮杂 - 金刚烷基脲作为热塑性材料的稳定剂
公开(公告)号：US4168260A
公开(公告)日：1979-09-18
申请号：US869826
申请日：1978-01-16
申请人： Hartmut Wiezer , Gerhard Pfahler , Norbert Mayer
发明人： Hartmut Wiezer , Gerhard Pfahler , Norbert Mayer
IPC分类号： C08K5/00 , C07D487/18 , C07D519/00 , C08K5/3467 , C08K5/3477 , C08L23/00 , C08L101/00 , C07D251/72 , C08K5/34
CPC分类号： C08K5/3477
摘要： The invention relates to a process for the stabilization of halogen-free or halogen-containing synthetic polymers against the degradation by light and heat, which comprises the addition of special 1,3,5-triaza-7-adamantanyl ureas to the polymers.
摘要翻译：本发明涉及一种稳定无卤素或含卤素合成聚合物以防止光和热降解的方法，其中包括向聚合物中加入特殊的1,3,5-三氮杂-7-金刚烷基脲。

7. 发明授权

US3983057A Process for the manufacture of water-clear copolymer dispersions 失效
标题翻译：用于制造水分透明共聚物分散体的方法
公开(公告)号：US3983057A
公开(公告)日：1976-09-28
申请号：US519240
申请日：1974-10-30
申请人： Gunther Illmann , Norbert Mayer
发明人： Gunther Illmann , Norbert Mayer
IPC分类号： C08F2/00 , C08F220/14 , C09G1/04 , C08L31/02
CPC分类号： C09G1/04 , C08F220/14
摘要： Copolymer dispersions can be prepared by emulsion polymerization of mixtures of unsaturated carboxylic acids and the esters thereof in the presence of regulators. Using sulfur containing compounds as regulators odorless and colorless dispersions which do not discolor are obtained if mercapto compounds having at least two SH-groups are used as regulator and the dispersions after polymerization are treated with hydrogen peroxide. The dispersions are especially suitable as film forming component in dry bright emulsions for the care of floors.
摘要翻译：共聚物分散体可以通过在调节剂存在下将不饱和羧酸及其酯的混合物进行乳液聚合来制备。使用含硫化合物作为调节剂，如果使用具有至少两个SH-基团的巯基化合物作为调节剂，并且用过氧化氢处理聚合后的分散体，则获得不变色的无味和无色分散体。分散体特别适合作为用于保护地板的干亮光乳液中的成膜组分。

8. 发明授权

US5026699A Use of 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-ones substituted in the 11-position for treating bradycardia and bradyarrhythmia in human and veterinary medicine 失效
标题翻译：在11位取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4]苯并二氮杂-6-酮在人和兽医学中用于治疗心动过缓和缓慢性心律失常
公开(公告)号：US5026699A
公开(公告)日：1991-06-25
申请号：US367397
申请日：1989-06-15
申请人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
发明人： Gerhard Mihm , Wolfgang Eberlein , Welfhard Engel , Gunter Trummlitz , Norbert Mayer , Henri Doods , Rudolf Hammer
IPC分类号： C07D471/04 , A61K31/55 , A61P1/00 , A61P9/04 , A61P9/06 , A61P11/00 , A61P13/02 , A61P15/00
CPC分类号： A61K31/55
摘要： 5,11-Dihydro-6H-pyrido[2,3-b][1,4]-benzo-diazepinones substituted in the 11-position corresponding to general formula I ##STR1## wherein R.sup.1 and R.sup.2 represent hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, A.sup.1 is a straight-chained or branched alkylene group with 1 to 5 carbon atoms, A.sup.2 is a methylene group or, if R.sup.1 is hydrogen and R.sup.2 is methyl, A.sup.2 may also be an ethylene group, and the physiologically acceptable acid addition salts thereof are suitable for treating bradycardia and bradyarrhythmia and spasm in the colon, bladder and bronchi.
摘要翻译：在对应于通式I（I）的11位上取代的5,11-二氢-6H-吡啶并[2,3-b] [1,4] - 苯并二氮杂其中R 1和R 2表示氢原子或具有1至3个碳原子的烷基，A1是具有1至5个碳原子的直链或支链亚烷基，A2是亚甲基，或者如果R1是氢，R2是甲基，A2也可以是亚乙基，其生理上可接受的酸加成盐适用于治疗结肠，膀胱和支气管中的心动过缓和缓慢性心律失常和痉挛。

9. 发明授权

US4873236A Condensed diazepinones, processes for preparing them and pharmaceutical compositions containing these compounds 失效
标题翻译：浓缩二氮杂酮，其制备方法和含有这些化合物的药物组合物
公开(公告)号：US4873236A
公开(公告)日：1989-10-10
申请号：US136212
申请日：1987-12-18
申请人： Wolfhard Engel , Wolfgang Eberlein , Gerhard Mihm , Gunter Trummlitz , Norbert Mayer , Adriaan De Jonge
发明人： Wolfhard Engel , Wolfgang Eberlein , Gerhard Mihm , Gunter Trummlitz , Norbert Mayer , Adriaan De Jonge
IPC分类号： C07D519/00 , A61K31/55 , A61P9/06 , A61P25/02 , C07D223/20 , C07D243/38 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/04
CPC分类号： C07D401/12 , C07D243/38 , C07D403/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： There are described new condensed diazepinones of general formula ##STR1## wherein .circle.B represents one of the divalent groups ##STR2## and D represents the groups ##STR3## and X.sup.1, X.sup.2 represents a .dbd.CH-- group or, if .circle.B assumes the meaning of the divalent group S, U or W, they may also represent an N atom, A.sup.1 and A.sup.2 in general represent lower alkylene groups, Z represents a C--C bond or the groups, --O--, --S--, --CH.sub.2 --, or --(CH.sub.2).sub.2 --; R represents hydrogen or methyl, R.sup.1 and R.sup.2 generally represent alkyl groups which, together with the nitrogen atom between them, may also form a saturated monocylic, heterocyclic group, R.sub.3 represents alkyl, chlorine or hydrogen, R.sub.4 represents hydrogen or methyl, R.sup.5 and R.sup.6 represent hydrogen, halogen or alkyl, R.sub.7 represents hydrogen, chlorine or methyl, R.sup.8 represents hydrogen or lower alkyl, R.sup.9 represents hydrogen, halogen, lower alkyl and R.sup.10 represents hydrogen or methyl and R.sup.12 represents branched or unbranched alkyl. The compounds of general formula I and the acid addition salts thereof may be resolved into their isomers. The compounds of formula I and their salts may be used as vagal pacemakers for the treatment of bradycardia and bradyarrhythmia.
摘要翻译：描述了通式为“IMAGE”（I）的新的缩合二氮杂酮，其中＆cir＆B表示二价基团之一 + TR ，D表示基团 + TR 和X1 ，X2表示a = CH-基团，或者如果＆Cir＆B表示二价基团S，U或W的含义，它们也可以表示N原子，A1和A2一般表示低级亚烷基，Z表示CC键或基团，-O - ， - S - ， - CH 2 - 或 - （CH 2）2 - ; R表示氢或甲基，R 1和R 2通常表示烷基，它们与氮原子一起也可以形成饱和单环，杂环基，R 3表示烷基，氯或氢，R 4表示氢或甲基，R 5和R 6 代表氢，卤素或烷基，R7代表氢，氯或甲基，R8代表氢或低级烷基，R9代表氢，卤素，低级烷基，R10代表氢或甲基，R12代表支链或非支链烷基。通式I的化合物及其酸加成盐可以分解成它们的异构体。式I化合物及其盐可用作迷走神经起搏器用于治疗心动过缓和缓慢性心律失常。

10. 发明授权

US4724236A 5,11-dihydro-6H-pyrido(2,3-B)(1,4)benzodiazepin-6-ones substituted in the 11-position, processes for preparing them and pharmaceutical compositions containing these compounds 失效
标题翻译：在11位被取代的5,11-二氢-6H-吡啶并（2,3-B）（1,4）苯并二氮杂-6-酮，其制备方法和含有这些化合物的药物组合物
公开(公告)号：US4724236A
公开(公告)日：1988-02-09
申请号：US944146
申请日：1986-12-19
申请人： Wolfgang Eberlein , Gunter Trummlitz , Wolfhard Engel , Gerhard Mihm , Rudolf Hammer , Norbert Mayer , Antonio Giachetti , Adriaan de Jonge
发明人： Wolfgang Eberlein , Gunter Trummlitz , Wolfhard Engel , Gerhard Mihm , Rudolf Hammer , Norbert Mayer , Antonio Giachetti , Adriaan de Jonge
IPC分类号： A61K31/55 , C07D471/04 , C07D403/14
CPC分类号： C07D471/04
摘要： Compounds of general formula I are described, ##STR1## wherein X represents the group .dbd.CHR, .dbd.NR or an oxygen atom andA represents the groups --NR.sup.1 R.sup.2,wherein R.sup.1 and R.sup.2 represent alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R.sup.3 represents a hydrogen atom, a hydroxy or alkyl group or a group --(CH.sub.2).sub.n --N--R.sup.5 R.sup.6 (R.sup.5 and R.sup.6 being lower alkyl groups) and R.sup.4 is an alkyl or phenylalkyl group; two processes for preparing these compounds and the salts thereof are also described.The compounds have favourable effects on heart rate and can be used as vagal pacemakers for treating bradycardia and bradyarrhythmia in human and veterinary medicine. Some of these compounds also have very good antithrombotic effects.
摘要翻译：描述通式I的化合物，其中X表示基团= CHR，= NR或氧原子，A表示基团-NR1R2，其中R1和R2表示烷基，环烷基或苯基烷基，n表示数字0,1或2，R3表示氢原子，羟基或烷基或基团 - （CH2）nN-R5R6（R5和R6是低级烷基），R4表示烷基或苯基烷基; 还描述了制备这些化合物及其盐的两种方法。这些化合物对心率有好的影响，可用作迷走神经心脏起搏器，用于治疗人和兽医学中的心动过缓和缓慢性心律失常。这些化合物中的一些也具有非常好的抗血栓形成作用。

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