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1. 发明申请

US20100036479A1 Stented Heart Valve Devices 有权
标题翻译：心脏瓣膜装置
公开(公告)号：US20100036479A1
公开(公告)日：2010-02-11
申请号：US12428737
申请日：2009-04-23
申请人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
发明人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stent frame including an annular portion having first and second ends, a central longitudinal axis, and a wire portion with at least two extending posts and a generally sinusoidal series of peaks and valleys between each of the at least two extending posts; an atrial portion extending from the first end of the annular portion, wherein the atrial portion includes a plurality of flares that extend radially outward relative to the longitudinal axis of the annular portion; and a ventricular portion extending from the second end of the annular portion, wherein the ventricular portion includes at least one flare that extends radially outward relative to the longitudinal axis of the annular portion.
摘要翻译：一种支架框架，包括具有第一端和第二端的环形部分，中心纵向轴线和具有至少两个延伸柱的线部分，以及在所述至少两个延伸柱中的每一个之间的大致正弦系列的峰和谷; 从所述环形部分的第一端延伸的心房部分，其中所述心房部分包括相对于所述环形部分的纵向轴线径向向外延伸的多个喇叭口; 以及从所述环形部分的第二端延伸的心室部分，其中所述心室部分包括相对于所述环形部分的纵向轴线径向向外延伸的至少一个耀斑。

2. 发明授权

US09173737B2 Stented heart valve devices 有权
标题翻译：支架心脏瓣膜装置
公开(公告)号：US09173737B2
公开(公告)日：2015-11-03
申请号：US12428737
申请日：2009-04-23
申请人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
发明人： Alexander J. Hill , Mark J. Capps , Carol E. Eberhardt , Morgan M. House , Stuart R. MacDonald , Joseph C. Morrow , Jerald Redmond , Janice L. Shay , Timothy R. Ryan
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stent frame including an annular portion having first and second ends, a central longitudinal axis, and a wire portion with at least two extending posts and a generally sinusoidal series of peaks and valleys between each of the at least two extending posts; an atrial portion extending from the first end of the annular portion, wherein the atrial portion includes a plurality of flares that extend radially outward relative to the longitudinal axis of the annular portion; and a ventricular portion extending from the second end of the annular portion, wherein the ventricular portion includes at least one flare that extends radially outward relative to the longitudinal axis of the annular portion.
摘要翻译：一种支架框架，包括具有第一端和第二端的环形部分，中心纵向轴线和具有至少两个延伸柱的线部分，以及在所述至少两个延伸柱中的每一个之间的大致正弦系列的峰和谷; 从所述环形部分的第一端延伸的心房部分，其中所述心房部分包括相对于所述环形部分的纵向轴线径向向外延伸的多个喇叭口; 以及从所述环形部分的第二端延伸的心室部分，其中所述心室部分包括相对于所述环形部分的纵向轴线径向向外延伸的至少一个耀斑。

3. 发明申请

US20090281618A1 Prosthetic Heart Valve Devices and Methods of Valve Replacement 有权
标题翻译：假体心脏瓣膜置换装置及方法
公开(公告)号：US20090281618A1
公开(公告)日：2009-11-12
申请号：US12429054
申请日：2009-04-23
申请人： Alexander J. Hill , Cynthia Clague , Carol Elsa Eberhardt , Ana R. Menk , Mark J. Capps , Billie J. Millwee , Janice Lynn Shay , Debra Ann Taitague , Joseph C. Morrow , Jerald Redmond
发明人： Alexander J. Hill , Cynthia Clague , Carol Elsa Eberhardt , Ana R. Menk , Mark J. Capps , Billie J. Millwee , Janice Lynn Shay , Debra Ann Taitague , Joseph C. Morrow , Jerald Redmond
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/24 , A61F2/2415 , A61F2/2418 , A61F2/2454 , A61F2/2457 , A61F2/2463 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stented valve of two or more leaflets made of pericardium or other material having a relatively thin profile at the annulus. The leaflet surfaces are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.
摘要翻译：由心包或其他材料制成的两个或更多个传单的支架瓣膜，在瓣环处具有较薄的轮廓。小叶表面通过和弦连接到支架框架上，其中和弦被定位成模拟天然瓣膜解剖结构和功能。特别地，本发明的一个示例性实施例的阀的尺寸被设计成代替二尖瓣，并且因此设置弦杆以防止小叶向中庭脱垂。由于和弦的定位，支架瓣膜在其环形处具有相对短的高度。此外，支架瓣膜能够被卷曲到足够小的尺寸，使得其可以经由经导管递送系统和方法递送到植入部位。

4. 发明授权

US08323336B2 Prosthetic heart valve devices and methods of valve replacement 有权
标题翻译：假体心脏瓣膜装置及瓣膜置换方法
公开(公告)号：US08323336B2
公开(公告)日：2012-12-04
申请号：US12429054
申请日：2009-04-23
申请人： Alexander J. Hill , Cynthia T. Clague , Carol Elsa Eberhardt , Ana R. Menk , Mark J. Capps , Billie J. Millwee , Janice Lynn Shay , Debra Ann Taitague , Joseph C. Morrow , Jerald Redmond
发明人： Alexander J. Hill , Cynthia T. Clague , Carol Elsa Eberhardt , Ana R. Menk , Mark J. Capps , Billie J. Millwee , Janice Lynn Shay , Debra Ann Taitague , Joseph C. Morrow , Jerald Redmond
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/24 , A61F2/2415 , A61F2/2418 , A61F2/2454 , A61F2/2457 , A61F2/2463 , A61F2/2487 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/001 , A61F2230/0045 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61F2250/0039
摘要： A stented valve of two or more leaflets made of pericardium or other material having a relatively thin profile at the annulus. The leaflet surfaces are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.
摘要翻译：由心包或其他材料制成的两个或更多个传单的支架瓣膜，在瓣环处具有较薄的轮廓。小叶表面通过和弦连接到支架框架上，其中和弦被定位成模拟天然瓣膜解剖结构和功能。特别地，本发明的一个示例性实施例的阀的尺寸被设计成代替二尖瓣，并且因此设置弦杆以防止小叶向中庭脱垂。由于和弦的定位，支架瓣膜在其环形处具有相对短的高度。此外，支架瓣膜能够被卷曲到足够小的尺寸，使得其可以经由经导管递送系统和方法递送到植入部位。

5. 发明申请

US20100305685A1 STENTED PROSTHETIC HEART VALVES 有权
标题翻译：阻塞的前置心脏瓣膜
公开(公告)号：US20100305685A1
公开(公告)日：2010-12-02
申请号：US12476702
申请日：2009-06-02
申请人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
发明人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0075 , A61F2230/0054
摘要： A surgical sutureless valve that is attached to a stent frame for delivery to a location in a patient using percutaneous implantation devices and methods.
摘要翻译：一种外科无缝合瓣膜，其连接到支架框架上，以使用经皮植入装置和方法递送至患者的位置。

6. 发明授权

US09968444B2 Stented prosthetic heart valves 有权
公开(公告)号：US09968444B2
公开(公告)日：2018-05-15
申请号：US13292623
申请日：2011-11-09
申请人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
发明人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0075 , A61F2230/0054
摘要： A surgical sutureless valve that is attached to a stent frame for delivery to a location in a patient using percutaneous implantation devices and methods.

7. 发明授权

US08075611B2 Stented prosthetic heart valves 有权
标题翻译：静脉假体心脏瓣膜
公开(公告)号：US08075611B2
公开(公告)日：2011-12-13
申请号：US12476702
申请日：2009-06-02
申请人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
发明人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0075 , A61F2230/0054
摘要： A surgical sutureless valve that is attached to a stent frame for delivery to a location in a patient using percutaneous implantation devices and methods.
摘要翻译：一种外科无缝合瓣膜，其连接到支架框架上，以使用经皮植入装置和方法递送至患者的位置。

8. 发明申请

US20120059454A1 Stented Prosthetic Heart Valves 有权
标题翻译：静脉止痛心脏瓣膜
公开(公告)号：US20120059454A1
公开(公告)日：2012-03-08
申请号：US13292623
申请日：2011-11-09
申请人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
发明人： Billie J. Millwee , Mark J. Capps , Janice L. Shay , Debra A. Taitague , Mark J. Dolan , Carol E. Eberhardt
IPC分类号： A61F2/84
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0075 , A61F2230/0054
摘要： A surgical sutureless valve that is attached to a stent frame for delivery to a location in a patient using percutaneous implantation devices and methods.
摘要翻译：一种外科无缝合瓣膜，其连接到支架框架上，以使用经皮植入装置和方法递送至患者的位置。

9. 发明授权

US5546820A Method and apparatus for testing of circumferentially compliant bioprosthetic valve 失效
公开(公告)号：US5546820A
公开(公告)日：1996-08-20
申请号：US339364
申请日：1994-11-14
申请人： Carol E. Eberhardt , Mark J. Capps , Luis Salazar
发明人： Carol E. Eberhardt , Mark J. Capps , Luis Salazar
IPC分类号： A61F2/24 , G01M10/00 , F16K37/00
CPC分类号： A61F2/2412 , A61F2/2472
摘要： A fixture for testing a circumferentially compliant bioprosthetic valve. The fixture comprises a silicone rubber simulated aorta which approximates the geometry of a healthy human aorta and a cradle for the aorta. The compliance characteristics of the aorta can be selected by varying the proportions of ingredients in the silicone rubber, so that simulated aortas of different compliance but identical geometries can be provided. The compliant valve is disposed inside the aorta and held in place by suturing or the like. In one embodiment, the aorta and valve are supported by means of a cylindrical cradle, with the inflow and outflow ends of the aorta being folded over cylindrical rims on the respective inflow and outflow ends of the cradle. End caps are then fitted in place over the folded-over ends of the aorta, the end caps having holes therein to allow flow through the aorta and valve. The end caps are provided with O-rings on their outer surfaces, so that the assembled fixture can be inserted into a testing apparatus, with the aorta and valve held in place in the sealed flow loop of the apparatus. In another embodiment, adapter rings are provided for the inflow and outflow ends of the aorta, with the ends of the aorta being folded over cylindrical rims disposed around the inner circumference of each of the adapter rings. The adapter rings are also provided with O-rings, allowing the ends of the aorta to be received in a testing apparatus so that the aorta and valve are disposed along the sealed flow loop of the apparatus.

10. 发明授权

US5406857A Method and apparatus for testing of circumferentially compliant bioprosthetic valve 失效
标题翻译：用于测量周向顺应生物假体瓣膜的方法和装置
公开(公告)号：US5406857A
公开(公告)日：1995-04-18
申请号：US910933
申请日：1992-07-09
申请人： Carol E. Eberhardt , Mark J. Capps , Luis Salazar
发明人： Carol E. Eberhardt , Mark J. Capps , Luis Salazar
IPC分类号： A61F2/24 , G01M19/00
CPC分类号： A61F2/2412 , A61F2/2472
摘要： A fixture for testing a circumferentially compliant bioprosthetic valve. The fixture comprises a silicone rubber simulated aorta which approximates the geometry of a healthy human aorta and a cradle for the aorta. The compliance characteristics of the aorta can be selected by varying the proportions of ingredients in the silicone rubber, so that simulated aortas of different compliance but identical geometries can be provided. The compliant valve is disposed inside the aorta and held in place by suturing or the like. In one embodiment, the aorta and valve are supported by means of a cylindrical cradle, with the inflow and outflow ends of the aorta being folded over cylindrical rims on the respective inflow and outflow ends of the cradle. End caps are then fitted in place over the folded-over ends of the aorta, the end caps having holes therein to allow flow through the aorta and valve. The end caps are provided with O-rings on their outer surfaces, so that the assembled fixture can be inserted into a testing apparatus, with the aorta and valve held in place in the sealed flow loop of the apparatus. In another embodiment, adapter rings are provided for the inflow and outflow ends of the aorta, with the ends of the aorta being folded over cylindrical rims disposed around the inner circumference of each of the adapter rings. The adapter rings are also provided with O-rings, allowing the ends of the aorta to be received in a testing apparatus so that the aorta and valve are disposed along the sealed flow loop of the apparatus.
摘要翻译：用于测试周向顺应性生物假体瓣膜的夹具。该固定装置包括模拟主动脉的硅橡胶，其近似于健康人主动脉的几何形状和用于主动脉的支架。可以通过改变硅橡胶中成分的比例来选择主动脉的顺应特性，从而可以提供不同顺应性但相同几何形状的模拟主动脉。顺应性阀设置在主动脉内部并通过缝合等保持在适当的位置。在一个实施例中，主动脉和瓣膜通过圆柱形支架支撑，主动脉的流入和流出端折叠在支架的相应流入和流出端上的圆柱形边缘上。然后将端盖安装在主动脉的折叠端上的适当位置，端盖在其中具有孔以允许流过主动脉和瓣膜。端盖在其外表面上设置有O形环，使得组装的夹具可以插入到测试装置中，其中主动脉和瓣膜保持在装置的密封流动回路中的适当位置。在另一个实施例中，为主动脉的流入端和流出端设置适配环，其中主动脉的端部折叠在围绕每个适配环的内圆周设置的圆柱形轮缘上。接头环还设置有O形环，允许主动脉的端部被接收在测试装置中，使得主动脉和瓣膜沿着装置的密封流动环路设置。

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