专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050100963A1 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 审中-公开
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：US20050100963A1
公开(公告)日：2005-05-12
申请号：US10661156
申请日：2003-09-11
申请人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
发明人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
IPC分类号： A61K38/00 , A61K48/00 , A61K49/22 , A61K51/08 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/71 , C12Q1/00 , G01N33/53 , C07K7/64 , A61K38/12
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译：本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力结合KDR或VEGF / KDR复合物的合成的分离的多肽（例如，具有K SUB D <1μM），以及包含这些多肽的二聚体和多聚体构建体。

2. 发明申请

US20050250700A1 KDR and VEGF/KDR binding peptides 审中-公开
标题翻译： KDR和VEGF / KDR结合肽
公开(公告)号：US20050250700A1
公开(公告)日：2005-11-10
申请号：US10939890
申请日：2004-09-13
申请人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Phillipe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
发明人： Aaron Sato , Daniel Sexton , Daniel Dransfield , Robert Ladner , Christophe Arbogast , Phillipe Bussat , Hong Fan , Sudha Khurana , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski
IPC分类号： A61K38/00 , A61K38/10 , C07K7/06 , C07K7/08 , C07K14/00 , G01N33/574 , G01N33/68
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/001 , G01N33/574 , G01N33/6872 , G01N2333/515 , G01N2500/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides, inter alia, peptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译：本发明尤其提供了包含至少一个KDR或VEGF / KDR复合物结合部分的肽，肽二聚体和多聚体复合物，其在治疗，检测，分离或定位血管发生的任何地方都具有多种用途。特别公开的是能够以高亲和力结合KDR或VEGF / KDR复合物的合成的分离的多肽（例如，具有K SUB D <1μM），以及包含这些多肽的二聚体和多聚体构建体。

4. 发明申请

US20070172428A1 MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 有权
标题翻译：用于治疗和诊断应用的多功能结构
公开(公告)号：US20070172428A1
公开(公告)日：2007-07-26
申请号：US11688968
申请日：2007-03-21
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski , Aaron Sato , Sharon Walker , Daniel Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski , Aaron Sato , Sharon Walker , Daniel Dransfield
IPC分类号： A61K49/22
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译：本发明提供用于治疗和诊断应用的组合物和方法。

5. 发明申请

US20050027105A9 Multivalent constructs for therapeutic and diagnostic applications 失效
标题翻译：用于治疗和诊断应用的多价结构
公开(公告)号：US20050027105A9
公开(公告)日：2005-02-03
申请号：US10661032
申请日：2003-09-11
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski , Aaron Sato , Sharon Walker , Daniel Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf Swenson , Mathew Von Wronski , Aaron Sato , Sharon Walker , Daniel Dransfield
IPC分类号： A61K47/48 , C07K7/08 , C07K7/64 , C07K16/44
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译：本发明提供用于治疗和诊断应用的组合物和方法。

6. 发明申请

US20060239914A1 Gastrin releasing peptide compounds 失效
公开(公告)号：US20060239914A1
公开(公告)日：2006-10-26
申请号：US11352156
申请日：2006-02-10
申请人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
IPC分类号： A61K51/00 , A61K49/00 , C07K14/775
CPC分类号： C07K14/57572 , A61K49/085 , A61K49/122 , A61K49/14 , A61K51/088
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

7. 发明申请

US20080008649A1 Gastrin Releasing Peptide Compounds 审中-公开
标题翻译：胃泌素释放肽化合物
公开(公告)号：US20080008649A1
公开(公告)日：2008-01-10
申请号：US11751337
申请日：2007-05-21
申请人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle , Mary Maddalena
发明人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Adrian Nunn , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle , Mary Maddalena
IPC分类号： A61K51/08 , A61P35/04
CPC分类号： C07K14/57572 , A61K49/085 , A61K49/122 , A61K49/14 , A61K51/088
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided. Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer, methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer.
摘要翻译：用于具有式MNOPG的诊断成像或治疗的新的和改进的化合物，其中M是具有以下结构的金属螯合剂：其中R 1 -R 5和FG如本文所定义（以与金属放射性核素复合的形式） NOP是含有至少一个具有环状基团，至少一个取代的胆汁酸或至少一个非α氨基酸的非α氨基酸的接头，G是GRP受体靶向肽。在优选的实施方案中，M是Aazta金属螯合剂或其衍生物。还提供了使用本发明的化合物对患者成像和/或向患者提供放射治疗或光疗的方法。还提供了用于从该化合物制备诊断显像剂的方法和试剂盒。还提供了用于制备放射治疗剂的方法和试剂盒。还提供了治疗前列腺肿瘤或延缓前列腺肿瘤进展的新方法，包括治疗前列腺癌骨或软组织转移的方法，治疗激素敏感性和激素难治性前列腺癌的方法，延迟激素进展的方法敏感前列腺癌，用于促进激素敏感性前列腺癌患者的联合治疗，并减少激素敏感性前列腺癌患者异常血管通透性。

8. 发明申请

US20060018830A1 Gastrin releasing peptide compounds 失效
公开(公告)号：US20060018830A1
公开(公告)日：2006-01-26
申请号：US11165721
申请日：2005-06-24
申请人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf Swenson , Michael Tweedle
IPC分类号： A61K51/00 , C07F5/00
CPC分类号： A61K51/088 , A61K49/0002 , C07C269/04 , C07D257/00 , C07J41/0005 , C07J41/0011 , C07J43/003 , C07K14/57572 , C07C271/22
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

9. 发明申请

US20050147555A1 Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same 有权
标题翻译：制备用于治疗和诊断应用的多价构建体的方法及其制备方法
公开(公告)号：US20050147555A1
公开(公告)日：2005-07-07
申请号：US10916155
申请日：2004-08-11
申请人： Hong Fan , Edmund Marinelli , Palaniappa Nanjappan , Radhakrishna Pillai , Rolf Swenson
发明人： Hong Fan , Edmund Marinelli , Palaniappa Nanjappan , Radhakrishna Pillai , Rolf Swenson
IPC分类号： A61K47/48 , C07K7/08 , C07K7/64 , A61K51/00 , A61K49/00
CPC分类号： A61K51/088 , A61K47/60 , A61K47/64 , A61K49/0043 , A61K49/0056 , A61K49/223 , B82Y5/00 , C07K7/08 , C07K7/64
摘要： Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative therof; or a diamine derivative. The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.
摘要翻译：提供了用于制备用于治疗和诊断应用的多价构建体的方法。更具体地，提供了用于制备包含用于治疗和诊断应用的式ABCDE-B'-F的多价构建体的新方法，其使用新的接头D，其在各种实施方案中包括二羧酸衍生物，例如戊二酸双 N-羟基琥珀酰亚胺酯或衍生物; 或二胺衍生物。多价构建体ABCDE-B'-F中的其余组分定义如下：A是第一个肽，B是第一个支化基团，C是可选的第一间隔基，E是可选的第二间隔基，其可以与或不同于所述第一间隔基C，B'是任选的第二支化基团，其可以与所述第一支化基团B相同或不同，F是可以与所述第一肽A相同或不同的第二肽。

10. 发明申请

US20070231257A1 Gastrin Releasing Peptide Compounds 审中-公开
标题翻译：胃泌素释放肽化合物
公开(公告)号：US20070231257A1
公开(公告)日：2007-10-04
申请号：US11467237
申请日：2006-08-25
申请人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Rolf Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Rolf Swenson , Michael Tweedle
IPC分类号： A61K51/08 , C07K14/595
CPC分类号： A61K51/088 , C07K7/086
摘要： New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
摘要翻译：用于具有式M-N-O-P-G的放射诊断成像或放射治疗的新的和改进的化合物，其中M是金属螯合剂（以与金属放射性核素复合的形式），N-O-P是接头，G是GRP受体靶向肽。还提供了使用本发明的化合物使患者成像和/或向患者提供放射疗法的方法。还提供了从化合物制备诊断显像剂的方法。还提供了一种制备放射治疗剂的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式