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1. 发明专利

IL268663A Dna repair blood test for predicting response of lung cancer patients to immunotherapy 未知
公开(公告)号：IL268663A
公开(公告)日：2021-03-01
申请号：IL26866319
申请日：2019-08-12
申请人： YEDA RES & DEV , ZVI LIVNEH , TAMAR PAZ ELIZUR
发明人： TAMAR PAZ-ELIZUR , ZVI LIVNEH
摘要： A method of selecting a treatment for a subject having cancer is disclosed. The method comprises: (a) determining a level of catalytic activity of at least one DNA repair enzyme in a biological sample of the subject; and (b) selecting an immune checkpoint regulator as a treatment for a subject having a statistically significant different level of catalytic activity of said DNA repair enzyme as compared to the catalytic activity of said DNA repair enzyme in a biological sample of a healthy subject.

2. 发明专利

IL290463A Dna repair blood test for predicting response of lung cancer patients to immunotherapy 未知
公开(公告)号：IL290463A
公开(公告)日：2022-04-01
申请号：IL29046322
申请日：2022-02-08
申请人： YEDA RES & DEVELOPMENT CO LTD , ZVI LIVNEH , TAMAR PAZ ELIZUR
发明人： ZVI LIVNEH , TAMAR PAZ-ELIZUR
摘要： A method of selecting a treatment for a subject having cancer is disclosed. The method comprises:(a) determining a level of catalytic activity of at least one DNA repair enzyme in a biological sample of the subject; and(b) selecting an immune checkpoint regulator as a treatment for a subject having a statistically significant different level of catalytic activity of said DNA repair enzyme as compared to the catalytic activity of said DNA repair enzyme in a biological sample of a healthy subject.

3. 发明专利

IL268663D0 Dna repair blood test for predicting response of lung cancer patients to immunotherapy 未知
公开(公告)号：IL268663D0
公开(公告)日：2019-11-03
申请号：IL26866319
申请日：2019-08-12
申请人： ZVI LIVNEH , TAMAR PAZ ELIZUR , YEDA RES & DEV
发明人： ZVI LIVNEH , TAMAR PAZ-ELIZUR
IPC分类号： C12Q20060101
摘要： A method of selecting a treatment for a subject having cancer is disclosed. The method comprises: (a) determining a level of catalytic activity of at least one DNA repair enzyme in a biological sample of the subject; and (b) selecting an immune checkpoint regulator as a treatment for a subject having a statistically significant different level of catalytic activity of said DNA repair enzyme as compared to the catalytic activity of said DNA repair enzyme in a biological sample of a healthy subject.

4. 发明专利

IL290463D0 Dna repair blood test for predicting response of lung cancer patients to immunotherapy 未知
公开(公告)号：IL290463D0
公开(公告)日：2022-04-01
申请号：IL29046322
申请日：2022-02-08
申请人： YEDA RES & DEVELOPMENT CO LTD , ZVI LIVNEH , TAMAR PAZ ELIZUR
发明人： ZVI LIVNEH , TAMAR PAZ-ELIZUR
IPC分类号： A61K39/39 , A61K39/00 , G01N33/574
摘要： A method of selecting a treatment for a subject having cancer is disclosed. The method comprises:(a) determining a level of catalytic activity of at least one DNA repair enzyme in a biological sample of the subject; and(b) selecting an immune checkpoint regulator as a treatment for a subject having a statistically significant different level of catalytic activity of said DNA repair enzyme as compared to the catalytic activity of said DNA repair enzyme in a biological sample of a healthy subject.

5. 发明专利

IL80746D0 REMOTE SWITCHING SYSTEM FOR A TRAVEL PATH OF A VEHICLE 未知
公开(公告)号：IL80746D0
公开(公告)日：1987-02-27
申请号：IL8074686
申请日：1986-11-24
申请人： ZVI LIVNEH
IPC分类号： B61L20060101 , B61L

6. 发明授权

US4763837A Frost free irrigation system and valve therefor 失效
标题翻译：无霜灌溉系统和阀门
公开(公告)号：US4763837A
公开(公告)日：1988-08-16
申请号：US63321
申请日：1987-06-18
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： A01G25/16 , B05B1/00 , B05B15/00
CPC分类号： A01G25/16 , Y10T137/7796
摘要： In one aspect a novel valve, when used with water conveying conduits of water supply or of irrigation systems, will purge them of residual water in the conduits, when the water supply is "cut off", but will close the system when the water supply is on (e.g. there is water pressure above a predetermined threshold, or a "head" occurs). When this valve is closed the system then operates, conventionally, and for irrigation systems to eject water from water dispensing nozzles or spray heads located at or in proximity to the ground surface so that irrigation can take place. With this novel valve, the periodic (or annual) need to purge the irrigation system of residual water to clean out contaminants or to prevent winter freeze-up is avoided, since self-purging of the residual water and of any water suspended solids in the network takes place each time the water pressure in the system is reduced to approximately zero (or to below the said predetermined threshold pressure), as on each occurance of water shut off. A further embodiment contamplates a compound nozzle valve assembly formed as a single structure housing a conventional water dispensing nozzle, and the novel purging valve. Such compound nozzle valve assembly simplifies installation of the irrigation system and of its subsequent operation and maintenance.
摘要翻译：在一个方面，一种新型阀当与供水或灌溉系统的输水管道一起使用时，在供水“切断”时将清除管道中的残留水，但在供水时将关闭系统（例如有高于预定阈值的水压，或发生“头”）。当该阀关闭时，系统常规地操作，并且用于灌溉系统以从位于地面或接近地面的水分配喷嘴或喷头喷出水，从而可以进行灌溉。使用这种新颖的阀门，可以避免周期性（或每年一次）清除灌溉系统的残留水，以清除污染物或防止冬季冻结，因为自来水中的残留水和任何水悬浮固体每当系统中的水压降低到大约零（或低于所述预定阈值压力）时，网络就会发生，因为每次发生水的关闭。另一实施例将复制喷嘴阀组件形成为容纳常规水分配喷嘴的单一结构和新颖的清洗阀。这种复合喷嘴阀组件简化了灌溉系统的安装及其随后的操作和维护。

7. 发明申请

US20110294134A1 METHODS AND KITS FOR DETERMINING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER 审中-公开
标题翻译：用于确定癌症风险的方法和工具，用于评估癌症治疗的有效性和剂量以及与DNA修复酶和癌症活性之间的相关性
公开(公告)号：US20110294134A1
公开(公告)日：2011-12-01
申请号：US13204737
申请日：2011-08-08
申请人： ZVI LIVNEH , TAMAR PAZ-ELIZUR , SARA BLUMENSTEIN
发明人： ZVI LIVNEH , TAMAR PAZ-ELIZUR , SARA BLUMENSTEIN
IPC分类号： C12Q1/68 , C12Q1/44
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2333/924 , G01N2333/988 , G01N2800/52
摘要： Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.
摘要翻译：方法和试剂盒，用于（i）确定受试者发展癌症的风险; （ii）评估给予癌症患者的癌症治疗的有效性和剂量; 并且（iii）确定至少一种DNA修复酶与至少一种癌症的活性之间的相关性或非相关性的存在。

8. 发明授权

US08043807B2 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer 有权
标题翻译：用于确定发展癌症的风险的方法和试剂盒，用于评估癌症治疗的有效性和剂量以及DNA修复酶与癌症的活性之间的相关性
公开(公告)号：US08043807B2
公开(公告)日：2011-10-25
申请号：US10469992
申请日：2002-03-21
申请人： Zvi Livneh , Tamar Paz-Elizur , Sara Blumenstein
发明人： Zvi Livneh , Tamar Paz-Elizur , Sara Blumenstein
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2333/924 , G01N2333/988 , G01N2800/52
摘要： Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.
摘要翻译：方法和试剂盒，用于（i）确定受试者发展癌症的风险; （ii）评估给予癌症患者的癌症治疗的有效性和剂量; 并且（iii）确定至少一种DNA修复酶与至少一种癌症的活性之间的相关性或非相关性的存在。

9. 发明申请

US20140248293A1 NOVEL RISK BIOMARKERS FOR LUNG CANCER 审中-公开
标题翻译：肺癌的新风险生物标志物
公开(公告)号：US20140248293A1
公开(公告)日：2014-09-04
申请号：US14343851
申请日：2012-09-06
申请人： Zvi Livneh , Tamar Paz-Elizur
发明人： Zvi Livneh , Tamar Paz-Elizur
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57423
摘要： Methods and kits for determining a risk of a subject, or subjects for developing lung cancer is disclosed. The method comprises determining a level of catalytic activity of N-methylpurine DNA glycosylase (MPG), or apurinic/apyrimidinic endonuclease 1 (APE1), or both, or MPG and 8-oxoguanine DNA glycosylase (OGG1), or MPG and APE1 and OGG1 in peripheral blood cells of a subject, wherein levels of MPG above a predetermined reference value, or APE1 or OGG1, or a integrated DNA repair score below a predetermined reference value is indicative of an increased risk of developing lung cancer.
摘要翻译：公开了用于确定受试者或发展中的肺癌受试者风险的方法和试剂盒。该方法包括测定N-甲基嘌呤DNA糖基化酶（MPG）或无嘌呤/脱嘧啶核苷酸内切酶1（APE1）或两者或MPG和8-氧基鸟嘌呤DNA糖基化酶（OGG1）或MPG和APE1和OGG1的催化活性水平在受试者的外周血细胞中，其中高于预定参考值或APE1或OGG1的水平的MPG或低于预定参考值的综合DNA修复评分指示发展为肺癌的风险增加。

10. 发明授权

US4736812A Remote switching mechanism 失效
标题翻译：远程切换机制
公开(公告)号：US4736812A
公开(公告)日：1988-04-12
申请号：US935213
申请日：1986-11-26
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： G05D1/02 , B60T7/16
CPC分类号： G05D1/0265 , G05D1/0261 , G05D2201/0216
摘要： Where automated travel of the vehicle is desired, and there are a number of branches, for directing the vehicle along a variety of different paths, it is be convenient for the vehicle to include a specific sensor means for sensing precoded control instructions placed contigious to the path, whereby to determine which branch path is to be selected by the vehicle as it travels among the main or any of a plurality of branch paths thereof so as to accomplish its task.
摘要翻译：在需要车辆的自动行驶的地方，并且存在用于沿着各种不同路径引导车辆的多个分支，车辆便于包括用于感测预编码的控制指令，以便接近于路径，由此确定车辆在主车辆或其多个分支路径中的任一个中行进时哪个分支路径被选择以便完成其任务。

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