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1. 发明授权

US08043807B2 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer 有权
标题翻译：用于确定发展癌症的风险的方法和试剂盒，用于评估癌症治疗的有效性和剂量以及DNA修复酶与癌症的活性之间的相关性
公开(公告)号：US08043807B2
公开(公告)日：2011-10-25
申请号：US10469992
申请日：2002-03-21
申请人： Zvi Livneh , Tamar Paz-Elizur , Sara Blumenstein
发明人： Zvi Livneh , Tamar Paz-Elizur , Sara Blumenstein
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2333/924 , G01N2333/988 , G01N2800/52
摘要： Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least one cancer, are disclosed.
摘要翻译：方法和试剂盒，用于（i）确定受试者发展癌症的风险; （ii）评估给予癌症患者的癌症治疗的有效性和剂量; 并且（iii）确定至少一种DNA修复酶与至少一种癌症的活性之间的相关性或非相关性的存在。

2. 发明申请

US20140248293A1 NOVEL RISK BIOMARKERS FOR LUNG CANCER 审中-公开
标题翻译：肺癌的新风险生物标志物
公开(公告)号：US20140248293A1
公开(公告)日：2014-09-04
申请号：US14343851
申请日：2012-09-06
申请人： Zvi Livneh , Tamar Paz-Elizur
发明人： Zvi Livneh , Tamar Paz-Elizur
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57423
摘要： Methods and kits for determining a risk of a subject, or subjects for developing lung cancer is disclosed. The method comprises determining a level of catalytic activity of N-methylpurine DNA glycosylase (MPG), or apurinic/apyrimidinic endonuclease 1 (APE1), or both, or MPG and 8-oxoguanine DNA glycosylase (OGG1), or MPG and APE1 and OGG1 in peripheral blood cells of a subject, wherein levels of MPG above a predetermined reference value, or APE1 or OGG1, or a integrated DNA repair score below a predetermined reference value is indicative of an increased risk of developing lung cancer.
摘要翻译：公开了用于确定受试者或发展中的肺癌受试者风险的方法和试剂盒。该方法包括测定N-甲基嘌呤DNA糖基化酶（MPG）或无嘌呤/脱嘧啶核苷酸内切酶1（APE1）或两者或MPG和8-氧基鸟嘌呤DNA糖基化酶（OGG1）或MPG和APE1和OGG1的催化活性水平在受试者的外周血细胞中，其中高于预定参考值或APE1或OGG1的水平的MPG或低于预定参考值的综合DNA修复评分指示发展为肺癌的风险增加。

3. 发明授权

US4763837A Frost free irrigation system and valve therefor 失效
标题翻译：无霜灌溉系统和阀门
公开(公告)号：US4763837A
公开(公告)日：1988-08-16
申请号：US63321
申请日：1987-06-18
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： A01G25/16 , B05B1/00 , B05B15/00
CPC分类号： A01G25/16 , Y10T137/7796
摘要： In one aspect a novel valve, when used with water conveying conduits of water supply or of irrigation systems, will purge them of residual water in the conduits, when the water supply is "cut off", but will close the system when the water supply is on (e.g. there is water pressure above a predetermined threshold, or a "head" occurs). When this valve is closed the system then operates, conventionally, and for irrigation systems to eject water from water dispensing nozzles or spray heads located at or in proximity to the ground surface so that irrigation can take place. With this novel valve, the periodic (or annual) need to purge the irrigation system of residual water to clean out contaminants or to prevent winter freeze-up is avoided, since self-purging of the residual water and of any water suspended solids in the network takes place each time the water pressure in the system is reduced to approximately zero (or to below the said predetermined threshold pressure), as on each occurance of water shut off. A further embodiment contamplates a compound nozzle valve assembly formed as a single structure housing a conventional water dispensing nozzle, and the novel purging valve. Such compound nozzle valve assembly simplifies installation of the irrigation system and of its subsequent operation and maintenance.
摘要翻译：在一个方面，一种新型阀当与供水或灌溉系统的输水管道一起使用时，在供水“切断”时将清除管道中的残留水，但在供水时将关闭系统（例如有高于预定阈值的水压，或发生“头”）。当该阀关闭时，系统常规地操作，并且用于灌溉系统以从位于地面或接近地面的水分配喷嘴或喷头喷出水，从而可以进行灌溉。使用这种新颖的阀门，可以避免周期性（或每年一次）清除灌溉系统的残留水，以清除污染物或防止冬季冻结，因为自来水中的残留水和任何水悬浮固体每当系统中的水压降低到大约零（或低于所述预定阈值压力）时，网络就会发生，因为每次发生水的关闭。另一实施例将复制喷嘴阀组件形成为容纳常规水分配喷嘴的单一结构和新颖的清洗阀。这种复合喷嘴阀组件简化了灌溉系统的安装及其随后的操作和维护。

4. 发明授权

US06333178B1 Methods of replicating a DNA molecule for repair of DNA lesion damage or for mutagenesis 失效
标题翻译：复制DNA分子修复DNA损伤损伤或诱变的方法
公开(公告)号：US06333178B1
公开(公告)日：2001-12-25
申请号：US09660552
申请日：2000-09-12
申请人： Zvi Livneh , Nina Bacher Reuven , Guy Tomer
发明人： Zvi Livneh , Nina Bacher Reuven , Guy Tomer
IPC分类号： C12P1934
CPC分类号： C12N9/1241 , C07K14/47 , C07K2319/00 , C12N15/10 , C12Q2521/101
摘要： UmuC is found to be a translesion replication DNA polymerase which replicates in the presence of UmuD′, RecA and SSB through a DNA lesion of damaged DNA molecule and which is found to be highly mutagenic during in vitro gap-filling replication. A method for replicating a DNA molecule with DNA lesion damage and a method for mutagenesis of a DNA molecule are provided.
摘要翻译： UmuC被发现是一种translesion复制DNA聚合酶，其在UmuD'，RecA和SSB存在下通过损伤的DNA分子的DNA损伤复制，并且在体外间隙填充复制过程中被发现是高度诱变的。提供了DNA分子复制DNA损伤损伤的方法和DNA分子的诱变方法。

5. 发明授权

US4657087A Vehicle control system including vehicle with steering and elevation control relative to a filament 失效
标题翻译：车辆控制系统包括相对于灯丝转向和升降控制的车辆
公开(公告)号：US4657087A
公开(公告)日：1987-04-14
申请号：US496967
申请日：1983-05-23
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： A01B69/04 , B62D1/28 , G05D1/02 , A01B63/114
CPC分类号： B62D1/28 , A01B69/008 , G05D1/0265 , G05D2201/0201
摘要： In a particular species of the preferred embodiment, the invention contemplates a land traveller such as a farm tractor pulling a passive load such as a plough, disc or the like. A control device for directing or controlling the path of travel of the vehicle over a field, and also regulating or controlling the depth of penetration of the plough or disc into the surface of the ground according to a predetermined depth irrespective of the terrain profile. The path control system consists of locating in a predetermined way, a track whose position is sensed by an electromagnet, and the relative position of the magnet is sensed by appropriate devices such as resistence measuring devices (strain gauges or variable resistors or reostats), photoelectric devices whose values are decoded through a microprocessor whereby steering of the prime mover along the predetermined path is maintained.
摘要翻译：在优选实施例的特定种类中，本发明设想了一个陆上旅行者，例如拉动诸如犁，盘等的被动负载的农用拖拉机。用于引导或控制车辆在场上的行进路径的控制装置，并且还根据预定的深度调节或控制犁或盘进入地面的深度，而与地形轮廓无关。路径控制系统包括以预定的方式定位其位置由电磁体感测的轨道，并且磁体的相对位置由诸如电阻测量装置（应变仪或可变电阻器或再稳定器）之类的适当装置感测，光电其装置的值通过微处理器解码，从而维持原动机沿预定路径的转向。

6. 发明授权

US4736812A Remote switching mechanism 失效
标题翻译：远程切换机制
公开(公告)号：US4736812A
公开(公告)日：1988-04-12
申请号：US935213
申请日：1986-11-26
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： G05D1/02 , B60T7/16
CPC分类号： G05D1/0265 , G05D1/0261 , G05D2201/0216
摘要： Where automated travel of the vehicle is desired, and there are a number of branches, for directing the vehicle along a variety of different paths, it is be convenient for the vehicle to include a specific sensor means for sensing precoded control instructions placed contigious to the path, whereby to determine which branch path is to be selected by the vehicle as it travels among the main or any of a plurality of branch paths thereof so as to accomplish its task.
摘要翻译：在需要车辆的自动行驶的地方，并且存在用于沿着各种不同路径引导车辆的多个分支，车辆便于包括用于感测预编码的控制指令，以便接近于路径，由此确定车辆在主车辆或其多个分支路径中的任一个中行进时哪个分支路径被选择以便完成其任务。

7. 发明授权

US4703536A Fluid motor driven washing accessory 失效
标题翻译：流体马达驱动洗衣配件
公开(公告)号：US4703536A
公开(公告)日：1987-11-03
申请号：US004234
申请日：1987-01-07
申请人： Zvi Livneh
发明人： Zvi Livneh
IPC分类号： A46B13/06 , A47K7/04 , A61H33/00
CPC分类号： A46B13/06 , A47K7/046 , Y10T74/18776
摘要： The present invention discloses a fluid driven washing device having a pressurized fluid supply conduit for supplying fluid to the device. The device is comprised of a handle portion, an assembly for producing reciprocating motion in the device, a control mechanism for controlling the reciprocating motion of the assembly, and a scrubbing member in communication with the reciprocating motion assembly, wherein the reciprocating motion assembly drives the scrubbing member in a rotating reciprocal motion. Mechanisms are also disclosed for supplying soap to the scrubbing member in a desired amount and integrating a shower head into the device.

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