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1. 发明授权

US07303922B2 Reagentless analysis of biological samples by applying mathematical algorithms to smoothed spectra 有权
标题翻译：通过应用数学算法平滑光谱对生物样品进行无谓分析
公开(公告)号：US07303922B2
公开(公告)日：2007-12-04
申请号：US10829777
申请日：2004-04-22
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/00
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

2. 发明授权

US07043287B1 Method for modulating light penetration depth in tissue and diagnostic applications using same 有权
标题翻译：用于调节组织中的透光深度的方法和使用其的诊断应用
公开(公告)号：US07043287B1
公开(公告)日：2006-05-09
申请号：US09419461
申请日：1999-10-15
申请人： Omar S. Khalil , Shu-Jen Yeh , Xiaomao Wu , Stanislaw Kantor , Charles F. Hanna , Tzyy-Wen Jeng
发明人： Omar S. Khalil , Shu-Jen Yeh , Xiaomao Wu , Stanislaw Kantor , Charles F. Hanna , Tzyy-Wen Jeng
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0059 , A61B5/1455 , A61B5/1495 , A61B2562/0242
摘要： Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte, in a biological sample, such as, for example, a body part. In these devices and methods, temperature is controlled and is varied between preset boundaries. The methods and devices measure light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a region in the sample wherein temperature is controlled. According to the method of this invention, the sampling depth dav, in human tissue is modified by changing the temperature of the tissue. The sampling depth increases as the temperature is lowered below the body core temperature and decreases when the temperature is raised within or above the body core temperature. Changing the temperature at the measurement site changes the light penetration depth in tissue and hence dav. Change in light penetration in tissue as a function of temperature can be used to estimate the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte in a biological sample. According to the method of this invention, an optical measurement is performed on a biological sample at a first temperature. Then, when the optical measurement is repeated at a second temperature, light will penetrate into the biological sample to a depth that is different from the depth to which light penetrates at the first temperature by from about 5% to about 20%.
摘要翻译：用于非侵入性地测量样品的至少一个参数的装置和方法，例如疾病状况的存在，疾病状态的进展，分析物的存在或分析物的浓度，例如，身体部位。在这些装置和方法中，控制温度并在预设的边界之间变化。方法和装置测量由样品中的平均采样深度d> av is is is is is is is measure measure measure measure measure measure measure measure measure measure measure measure measure measure measure or or wherein wherein wherein wherein wherein wherein。。。。。。。。根据本发明的方法，通过改变组织的温度来改变人体组织中的采样深度d>。。当温度降低到体芯温度以下时，采样深度增加，当温度升高到体芯内温度以上时，采样深度降低。改变测量部位的温度会改变组织中的光穿透深度，从而改变组织的光穿透深度。可以使用作为温度的函数的组织中的光穿透的变化来估计生物样品中疾病状况，疾病状态的进展，分析物的存在或分析物的浓度的存在。根据本发明的方法，在第一温度下对生物样品进行光学测量。然后，当在第二温度下重复光学测量时，光将穿透生物样品至与第一温度下的光渗透约5％至约20％的深度不同的深度。

3. 发明授权

US6087182A Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US6087182A
公开(公告)日：2000-07-11
申请号：US141483
申请日：1998-08-27
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/64 , G01N21/05 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/41 , G01N21/65 , G01N33/483 , G01N33/493 , G01N21/25
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e.g, urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如尿素，例如尿液。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

4. 发明授权

US5064541A Devices and methods for the collection of a predetermined volume of plasma or serum 失效
标题翻译：用于收集预定体积的血浆或血清的装置和方法
公开(公告)号：US5064541A
公开(公告)日：1991-11-12
申请号：US499864
申请日：1990-03-27
申请人： Tzyy-Wen Jeng , Kristin D. Elmore , Gary M. Oosta , Terry A. Pry
发明人： Tzyy-Wen Jeng , Kristin D. Elmore , Gary M. Oosta , Terry A. Pry
IPC分类号： B01D39/00 , B01D39/16 , B01D39/18 , B01D39/20 , B01L3/00 , G01N33/49 , G01N33/52 , G01N33/53
CPC分类号： B01L3/508 , B01D39/00 , B01D39/163 , B01D39/1661 , B01D39/18 , B01D39/201 , B01D39/2034 , B01D39/2075 , B01L3/5023 , G01N33/491 , G01N33/526 , G01N33/5302 , B01L2200/12 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , Y10T436/25375
摘要： A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum of plasma from the matrix.According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix as the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix.Another aspect of the present invention involves a device for the measurement of a serum or plasma sample, utilizing a matrix of sintered porous material, such as sintered glass, sintered steel, sintered ceramics, sintered plastics, and equivalents thereof. The matrix is characterized by a reproducible fluid uptake capacity proportional to the fixed dimensions of said matrix, a minimal reactivity with plasma or serum components, and a hydrophilic internal surface which enables the matrix to collect and retain a predetermined volume of sample for analysis.
摘要翻译：允许血浆或血清从全血分离的装置和方法。该装置包括已经施加至少一种红细胞凝集剂的亲水性烧结多孔材料的基质。根据使用该装置的第一种方法，将全血样品施加到基质的第一端，并且样品内的红细胞与存在于基质中的凝集剂接触。血细胞凝集，并被截留在基质的空隙中，而基本上无血细胞的血清或血浆聚集在装置的出口附近。与基质液体接收关系的过滤装置用于从基质中吸收血浆的血清。根据本发明的另一方面，与基质的出口液体接收关系的过滤器装置用于保持通过基质的任何血细胞，因为过滤器装置将血浆或血清从基质中吸出。可以在过滤器装置内并入额外的凝集剂以促进通过基质的血细胞的保留。本发明的另一方面涉及一种利用烧结多孔材料如烧结玻璃，烧结钢，烧结陶瓷，烧结塑料及其等同物的基质来测量血清或血浆样品的装置。该基质的特征在于与所述基质的固定尺寸成比例的可再现的流体吸收能力，与血浆或血清组分的最小反应性，以及亲水性内表面，其使基质收集并保留预定体积的样品用于分析。

5. 发明授权

US08315681B2 Method for noninvasive measurement of glucose and apparatus for noninvasive measurement of glucose 有权
标题翻译：用于无创测量葡萄糖的方法和用于无创测量葡萄糖的装置
公开(公告)号：US08315681B2
公开(公告)日：2012-11-20
申请号：US12418899
申请日：2009-04-06
申请人： Shoichi Kanayama , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh
发明人： Shoichi Kanayama , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0053 , A61B5/14532 , A61B5/1491 , A61B5/1495 , A61B5/6824 , A61B5/6843
摘要： A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals.
摘要翻译：一种用于对受试者的组织中的葡萄糖进行非侵入性测量的方法，包括以下步骤：将具有与测量探针类似的形状的适应装置与受试者的皮肤部分接触以拉伸受试者的皮肤部分在非侵入性测量期间高于测量探针施加的每单位面积的压力的压力下，将接触保持预定的时间段，然后释放接触，使测量探针与被拉伸的皮肤部分接触主观无创测量，收集从受试者发射的信号，并根据收集的信号估计葡萄糖浓度。

6. 发明授权

US08099243B2 Methods for quantifying a concentration of a target nucleic acid 有权
标题翻译：定量靶核酸浓度的方法
公开(公告)号：US08099243B2
公开(公告)日：2012-01-17
申请号：US12189358
申请日：2008-08-11
申请人： Eric B. Shain , John M. Clemens , Tzyy-Wen Jeng , George J. Schneider
发明人： Eric B. Shain , John M. Clemens , Tzyy-Wen Jeng , George J. Schneider
IPC分类号： G06F19/00 , C12P19/34 , C12Q1/68
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译：用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。

7. 发明授权

US07565250B2 Method and system for analyzing reactions using an information system 有权
标题翻译：使用信息系统分析反应的方法和系统
公开(公告)号：US07565250B2
公开(公告)日：2009-07-21
申请号：US10991025
申请日：2004-11-17
申请人： Eric B. Shain , John M. Clemens , Tzyy-Wen Jeng , George J. Schneider
发明人： Eric B. Shain , John M. Clemens , Tzyy-Wen Jeng , George J. Schneider
IPC分类号： G06F19/00 , C12P19/34 , C12Q1/68
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译：用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。

8. 发明授权

US06426045B1 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06426045B1
公开(公告)日：2002-07-30
申请号：US09407716
申请日：1999-09-28
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

9. 发明授权

US06241663B1 Method for improving non-invasive determination of the concentration of analytes in a biological sample 有权
公开(公告)号：US06241663B1
公开(公告)日：2001-06-05
申请号：US09302207
申请日：1999-04-29
申请人： Xiaomao Wu , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh , Charles F. Hanna
发明人： Xiaomao Wu , Omar S. Khalil , Tzyy-Wen Jeng , Shu-Jen Yeh , Charles F. Hanna
IPC分类号： A61B500
CPC分类号： G01N21/4795 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , A61B5/6824 , A61B2562/0233 , A61B2562/0242 , A61B2562/043
摘要： A method for determining the concentration of an analyte in a biological sample comprising the steps of: (1) providing an optical measuring instrument that comprises at least one thermally controllable optical measuring element that comes into contact with the surface of the biological sample; (2) applying an inert, thermally conductive, optically transparent coupling agent to the at least one optical measuring element or to the surface of the biological sample or both so that the coupling agent will be disposed at the interface of the surface of the biological sample and the at least one optical measuring element; (3) measuring optical properties of the biological sample by means of the optical measuring instrument; and (4) correlating the optical properties of the biological sample with the concentration of the analyte in the biological sample. A coupling agent suitable for this invention must have several properties to enable it to help decrease measurement variation, especially drift. One of the most important properties is sufficiently high optical stability that the optical properties of the coupling agent do not change even during prolonged experiments, such as oral glucose tolerance tests. Secondly, the coupling agent should have sufficiently high thermal conductivity to allow fast, efficient heat transfer between the optical probe and the biological sample. Third, the coupling agent should have sufficiently high viscosity to prevent it from migrating from the measurement area. Yet, it should also have sufficiently low viscosity to allow sufficient contact between the optical probe and the biological sample and to permeate into any small pockets between the probe and the biological sample that would otherwise be filled with the air. Fourth, the coupling agent should be inert. Material from the coupling agent should not diffuse into the biological sample and material from the biological sample should not diffuse into the coupling agent.

10. 发明授权

US4933092A Methods and devices for the separation of plasma or serum from whole blood 失效
标题翻译：用于从全血中分离血浆或血清的方法和装置
公开(公告)号：US4933092A
公开(公告)日：1990-06-12
申请号：US335064
申请日：1989-04-07
申请人： Diane L. Aunet , Gradimir G. Gerogevich , Tzyy-Wen Jeng , Gary M. Oosta , Neal A. Siegel
发明人： Diane L. Aunet , Gradimir G. Gerogevich , Tzyy-Wen Jeng , Gary M. Oosta , Neal A. Siegel
IPC分类号： B01D39/00 , B01D39/16 , B01D39/18 , B01D39/20 , B01L3/00 , B01L3/14 , G01N33/49 , G01N33/52
CPC分类号： B01L3/50825 , B01D39/00 , B01D39/163 , B01D39/1661 , B01D39/18 , B01D39/201 , B01D39/2034 , B01D39/2075 , B01L3/5023 , G01N33/491 , G01N33/526 , B01L2300/046 , B01L2300/0681 , B01L2300/087 , B01L2400/0406 , Y10T436/25375
摘要： A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum or plasma from the matrix.According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix is the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix.
摘要翻译：允许血浆或血清从全血分离的装置和方法。该装置包括已经施加至少一种红细胞凝集剂的亲水性烧结多孔材料的基质。根据使用该装置的第一种方法，将全血样品施加到基质的第一端，并且样品内的红细胞与存在于基质中的凝集剂接触。血细胞凝集，并被截留在基质的空隙中，而基本上无血细胞的血清或血浆聚集在装置的出口附近。与基质液体接收关系的过滤装置用于从基质中吸收血清或血浆。根据本发明的另一方面，与基质的出口液体接收关系的过滤装置用于保持通过基质的任何血细胞，过滤装置将血浆或血清从基质中吸出。可以在过滤器装置内并入额外的凝集剂以促进通过基质的血细胞的保留。

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