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1. 发明申请

US20060034889A1 Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof 审中-公开
标题翻译：具有反向热凝胶化性质的可生物降解的二嵌段共聚物及其使用方法
公开(公告)号：US20060034889A1
公开(公告)日：2006-02-16
申请号：US10919603
申请日：2004-08-16
申请人： Seongbong Jo , Ai-Zhi Piao
发明人： Seongbong Jo , Ai-Zhi Piao
IPC分类号： C08F20/00 , A61F2/00
CPC分类号： A61K47/34 , A61K9/0024 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/604 , A61L2300/64 , C08G63/664 , C08G64/183 , C08L53/00 , C08L53/005 , C08L2666/02
摘要： A water soluble, biodegradable AB type diblock copolymer which comprises 61 to 85% by weight of a biodegradable, hydrophobic A block comprising a biodegradable polyester, and 15 to 39% by weight of a biocompatible, hydrophilic B block comprising a monofunctional polyethylene glycol(PEG) having a number average molecular weight less than 5000, and wherein said diblock copolymer has a number average molecular weight less than 15000 and possesses reverse thermal gelation properties.
摘要翻译：一种水溶性可生物降解的AB型二嵌段共聚物，其包含61至85重量％的包含可生物降解聚酯的可生物降解的疏水性A嵌段和15至39重量％的生物相容性亲水性B嵌段，其包含单官能聚乙二醇（PEG ），其中所述二嵌段共聚物的数均分子量小于15000，具有反向热凝胶化特性。

2. 发明授权

US06306821B1 Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) 有权
标题翻译：官能化聚（富马酸丙烯酯）和聚（丙烯富马酸酯 - 共 - 乙二醇）
公开(公告)号：US06306821B1
公开(公告)日：2001-10-23
申请号：US09549483
申请日：2000-04-14
申请人： Antonios G. Mikos , Seongbong Jo
发明人： Antonios G. Mikos , Seongbong Jo
IPC分类号： A23L128
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： Poly(ethylene glycol) (PEG), a highly biocompatible hydrophilic polyether, is tethered to poly(propylene fumarate) (PPF), a biodegradable polyester. To avoid change in molecular weight distribution of PPF, end hydroxyl groups of PPF are reacted with bis-carboxymethyl PEG after being treated with thionyl chloride. New end carboxyl groups of the PEG-tethered PPF are further reacted with N-hydroxysuccinimide (NHS) in the presence of dicyclohexylcarbodiimide (DCC) to couple bioactive molecules. Glutamine and glycine-arginine-glycine-aspartic acid (GRGD) are attached to the PEG-tethered PPF in 50 mM phosphate buffer of pH of 7.4. The method is valuable for the preparation of a triblock copolymer with PEG end blocks and the coupling of biologically active molecules.
摘要翻译：聚（乙二醇）（PEG），一种高度生物相容的亲水性聚醚，连接于聚（丙烯富马酸酯）（PPF），一种可生物降解的聚酯。为了避免PPF的分子量分布发生变化，用亚硫酰氯处理后，PPF的末端羟基与双 - 羧甲基PEG反应。在二环己基碳二亚胺（DCC）存在下，PEG-束缚PPF的新端羧基进一步与N-羟基琥珀酰亚胺（NHS）反应以偶联生物活性分子。谷氨酰胺和甘氨酸 - 精氨酸 - 甘氨酸 - 天冬氨酸（GRGD）在pH 7.4的50mM磷酸盐缓冲液中连接到PEG-束缚的PPF上。该方法对于制备具有PEG端嵌段和生物活性分子偶联的三嵌段共聚物是有价值的。

3. 发明申请

US20070265356A1 Aliphatically modified biodegradable block copolymers as thermogelling polymers 有权
标题翻译：脂肪族改性的生物可降解嵌段共聚物作为热凝胶聚合物
公开(公告)号：US20070265356A1
公开(公告)日：2007-11-15
申请号：US11784528
申请日：2007-04-06
申请人： Sung Kim , Seongbong Jo , Jin Kim
发明人： Sung Kim , Seongbong Jo , Jin Kim
IPC分类号： A61F2/02 , C07D313/02 , C08L67/04
CPC分类号： C08L67/04 , A61K9/0024 , A61K9/06 , A61K47/34 , C08G63/664
摘要： A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.
摘要翻译：描述了用于药物递送的耐热凝胶，脂质改性聚合物。说明性实施方案包括聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）己酸酯和聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）月桂酸酯。另一个说明性实施方案包括具有热胶凝量的脂族改性聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）和有效量的药物的组合物。热胶凝聚合物通过将脂族基团键合到聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）而制备。一种使用方法包括用热胶凝量的脂质改性聚合物和药物注射温血个体。

4. 发明授权

US06884778B2 Biocompatible macromers 有权
标题翻译：生物相容的大分子单体
公开(公告)号：US06884778B2
公开(公告)日：2005-04-26
申请号：US09845570
申请日：2001-04-30
申请人： Seongbong Jo , Antonios G. Mikos
发明人： Seongbong Jo , Antonios G. Mikos
IPC分类号： A61K47/48 , A61L27/18 , C08G63/676 , C08G63/91 , C08G65/329 , C08G65/332 , C08G81/02 , A61K38/16 , A61K9/70
CPC分类号： C08G65/3322 , A61K47/60 , A61L27/18 , C08G63/676 , C08G63/918 , C08G65/329 , C08G81/025 , C08L67/00
摘要： A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerization in the presence of either a chemical or photo initiator. A cross-linked OPF gel has a swelling behavior that is tunable dependent on the molecular weight of PEG. A cross-linkable PEG macromer, as exemplified by oligo(PEG fumarate), has unsaturated double bonds, for example in the fumaryl groups, along its macromolecular chain that allows for the preparation of hydrogels with tailored structure and properties.
摘要翻译：提供了基于交替富马酸和聚（乙二醇）（PEG）单元的新的低聚物。寡聚（富马酸戊二醇酯）（OPF）可通过用生物相容性有机基团进行改性来官能化。此外，OPF可以在化学或光引发剂的存在下使用自由基聚合进行交联。交联的OPF凝胶具有取决于PEG的分子量的可调谐的溶胀行为。可交联的PEG大分子单体如寡聚（富马酸PEG）所示，具有不饱和双键，例如在富马酰基中沿其大分子链，其允许用定制的结构和性质制备水凝胶。

5. 发明授权

US07740877B2 Aliphatically modified biodegradable block copolymers as thermogelling polymers 有权
标题翻译：脂肪族改性的生物可降解嵌段共聚物作为热凝胶聚合物
公开(公告)号：US07740877B2
公开(公告)日：2010-06-22
申请号：US11784528
申请日：2007-04-06
申请人： Sung Wan Kim , Seongbong Jo , Jin Kim
发明人： Sung Wan Kim , Seongbong Jo , Jin Kim
IPC分类号： A61F2/02 , C08G63/08
CPC分类号： C08L67/04 , A61K9/0024 , A61K9/06 , A61K47/34 , C08G63/664
摘要： A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.
摘要翻译：描述了用于药物递送的耐热凝胶，脂质改性聚合物。说明性实施方案包括聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）己酸酯和聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）月桂酸酯。另一个说明性实施方案包括具有热凝胶量的脂族改性聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）和有效量的药物。热胶凝聚合物通过将脂族基团与聚（乳酸 - 共 - 己内酯） - 聚（乙二醇） - 聚（乳酸 - 共 - 己内酯）结合而制备。一种使用方法包括用热胶凝量的脂质改性聚合物和药物注射温血个体。

6. 发明申请

US20060018949A1 Injectable biodegradable drug delivery system 审中-公开
标题翻译：可注射生物降解药物输送系统
公开(公告)号：US20060018949A1
公开(公告)日：2006-01-26
申请号：US11079872
申请日：2005-03-14
申请人： Daniel Ammon , Joseph Salamone , Hiroki Ueda , Seongbong Jo , Antonios Mikos
发明人： Daniel Ammon , Joseph Salamone , Hiroki Ueda , Seongbong Jo , Antonios Mikos
IPC分类号： A61F2/00
CPC分类号： A61K9/1635 , A61K9/0051 , A61K9/1647 , A61K47/32 , A61K47/34
摘要： Compositions for delivering a pharmaceutically active agent to the eye, and/or for treating an ophthalmic disorder, are based on a fumarate polymer, especially a poly(propylene fumarate) polymer.
摘要翻译：将药物活性剂递送至眼睛和/或用于治疗眼科疾病的组合物基于富马酸酯聚合物，特别是聚（富马酸丙二醇酯）聚合物。

7. 发明授权

US6013855A Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces 失效
标题翻译：将生物相容的亲水聚合物接枝到无机和金属表面上
公开(公告)号：US6013855A
公开(公告)日：2000-01-11
申请号：US774707
申请日：1996-12-26
申请人： Timothy McPherson , Kinam Park , Seongbong Jo
发明人： Timothy McPherson , Kinam Park , Seongbong Jo
IPC分类号： A61L27/34 , B05D7/16 , A61F2/02
CPC分类号： B05D7/16 , A61L27/34
摘要： Methods for grafting unmodified PEO or any other water-soluble polymers to the surfaces of metals and glasses to form biocompatible surfaces having low protein affinity is provided. One technique includes the steps of: (a) providing a support member having a plurality of hydroxyl or oxide groups attached to a surface of said support member; (b) exposing said surface to a silane coupling agent to cause the silane coupling agent to form a silane layer that is covalently bound to the surface wherein the silane layer comprises a plurality of vinyl groups; and (c) exposing the silane layer to a hydrophilic polymer and causing the silane layer to react with the hydrophilic polymer to covalently bond to the silane layer. Exposure of the silane layer to .gamma.-radiation to induce grafting with low radiation to induce grafting of the hydrophilic polymer to the silane layer. Another technique comprises grafting a silylated hydrophilic polymer or chain having a hydrophobic domain directly to the metal or inorganic surface.
摘要翻译：提供了将未改性的PEO或任何其它水溶性聚合物接枝到金属和玻璃的表面以形成具有低蛋白质亲和力的生物相容性表面的方法。一种技术包括以下步骤：（a）提供具有附着到所述支撑构件的表面上的多个羟基或氧化物基团的支撑构件; （b）将所述表面暴露于硅烷偶联剂以使硅烷偶联剂形成共价结合到表面的硅烷层，其中硅烷层包含多个乙烯基; 和（c）将硅烷层暴露于亲水性聚合物，并使硅烷层与亲水性聚合物反应以共价结合到硅烷层。将硅烷层暴露于γ-辐射以诱导低辐射接枝以诱导亲水性聚合物接枝到硅烷层。另一种技术包括将具有疏水性域的甲硅烷基化亲水性聚合物或链直接接枝到金属或无机表面。

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