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1. 发明申请

US20080020434A1 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译：用于生产莫纳甜及其前体的立体异构体的多肽和生物合成途径
公开(公告)号：US20080020434A1
公开(公告)日：2008-01-24
申请号：US11714279
申请日：2007-03-06
申请人： Brian Brazeau , Mervyn De Souza , Steven Gort , Paula Hicks , Sherry Kollmann , Jose Laplaza , Sara McFarlan , Fernando Sanchez-Riera , Christopher Solheid
发明人： Brian Brazeau , Mervyn De Souza , Steven Gort , Paula Hicks , Sherry Kollmann , Jose Laplaza , Sara McFarlan , Fernando Sanchez-Riera , Christopher Solheid
IPC分类号： C12P13/02 , C07H21/04 , C12N1/20 , C12N9/00 , C12P13/22 , C12N9/02 , C12N9/10 , C12N9/90
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

2. 发明申请

US20050112260A1 Monatin tabletop sweetener compositions and methods of making same 审中-公开
标题翻译： Monatin桌面甜味剂组合物及其制备方法
公开(公告)号：US20050112260A1
公开(公告)日：2005-05-26
申请号：US10903582
申请日：2004-08-02
申请人： Timothy Abraham , Douglas Cameron , Melanie Goulson , Paula Hicks , Michael Lindley , Sara McFarlan , James Millis , John Rosazza , Lishan Zhao , David Weiner
发明人： Timothy Abraham , Douglas Cameron , Melanie Goulson , Paula Hicks , Michael Lindley , Sara McFarlan , James Millis , John Rosazza , Lishan Zhao , David Weiner
IPC分类号： A23L27/20 , A21D13/08 , A23C9/154 , A23F3/00 , A23F3/30 , A23F5/00 , A23G1/00 , A23G3/34 , A23L2/02 , A23L2/60 , A23L9/10 , A23L27/00 , A23L27/30 , C12P17/10 , A23L1/236
CPC分类号： A23C9/1544 , A21D13/80 , A23F3/30 , A23G1/56 , A23L2/60 , A23L27/31 , A23L27/32 , A23G2200/06
摘要： The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
摘要翻译：本发明涉及包含莫纳甜的新型甜味剂组合物和制备这种组合物的方法。本发明还涉及包含特定莫纳甜立体异构体，莫纳甜立体异构体的特异性共混物和/或通过体内生物合成途径（例如细胞内）或体外产生的莫纳甜的甜味剂组合物。

3. 发明申请

US20050106305A1 Beverage compositions comprising monatin and methods of making same 审中-公开
标题翻译：包含莫纳甜的饮料组合物及其制备方法
公开(公告)号：US20050106305A1
公开(公告)日：2005-05-19
申请号：US10925216
申请日：2004-08-25
申请人： Timothy Abraham , Douglas Cameron , Melanie Goulson , Paula Hicks , Michael Lindley , Sara McFarlan , James Millis , John Rosazza , Lishan Zhao , David Weiner
发明人： Timothy Abraham , Douglas Cameron , Melanie Goulson , Paula Hicks , Michael Lindley , Sara McFarlan , James Millis , John Rosazza , Lishan Zhao , David Weiner
IPC分类号： A23L27/30 , A23L2/60 , A23L1/236
CPC分类号： A23L2/60 , A23L27/31
摘要： The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
摘要翻译：本发明涉及包含莫纳甜的新型饮料组合物和制备这种组合物的方法。本发明还涉及包含特定莫纳甜立体异构体，莫纳甜立体异构体的特异性共混物和/或通过体内生物合成途径（例如细胞内）或体外产生的莫纳甜的饮料组合物。

4. 发明申请

US20050282260A1 Polypeptides and biosynthetic pathways for the production of monatin and its precursors 有权
标题翻译：用于生产莫纳甜及其前体的多肽和生物合成途径
公开(公告)号：US20050282260A1
公开(公告)日：2005-12-22
申请号：US11114922
申请日：2005-04-26
申请人： Paula Hicks , Sara McFarlan
发明人： Paula Hicks , Sara McFarlan
IPC分类号： C12P17/10 , C12P13/22 , C12N1/18
CPC分类号： C12P17/10 , C12N15/52
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

7. 发明申请

US20080020435A1 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US20080020435A1
公开(公告)日：2008-01-24
申请号：US11714909
申请日：2007-03-07
申请人： Ellen Burke , Steven Gort , Paula Hicks , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen Burke , Steven Gort , Paula Hicks , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

8. 发明申请

US20060252135A1 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
公开(公告)号：US20060252135A1
公开(公告)日：2006-11-09
申请号：US11411229
申请日：2006-04-26
申请人： Brian Brazeau , Ellen Burke , Mervyn DeSouza , Steven Gort , Paula Hicks , Sherry Kollmann , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Fernando Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Brian Brazeau , Ellen Burke , Mervyn DeSouza , Steven Gort , Paula Hicks , Sherry Kollmann , Peter Luginbuhl , Sara McFarlan , Toby Richardson , Fernando Sanchez-Riera , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12N9/10 , C12P13/22 , C12N1/21
CPC分类号： C12P17/10 , C12N9/1096 , C12N9/90
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

9. 发明申请

US20050239173A1 Production of amino sugars 审中-公开
标题翻译：生产氨基糖
公开(公告)号：US20050239173A1
公开(公告)日：2005-10-27
申请号：US11004843
申请日：2004-12-07
申请人： Sara McFarlan , William Schroeder , Lawrence Fosdick , John Bohlmann
发明人： Sara McFarlan , William Schroeder , Lawrence Fosdick , John Bohlmann
IPC分类号： C07H20060101 , C12N1/18 , C12P19/28
CPC分类号： C12P19/28 , C12N1/18
摘要： The present invention provides a method for producing an amino sugar selected from the group consisting of N-acetylglucosamine, glucosamine, or a combination thereof. The method comprises culturing a yeast in a culture medium and recovering N-acetylglucosamine, glucosamine, or a combination thereof, wherein the yeast comprises an exogenous nucleic acid sequence encoding glucosamine-6-phosphate synthase operably linked to a promoter. The invention also provides a genetically modified yeast that produces an amino sugar selected from the group consisting of N-acetylglucosamine, glucosamine, or a combination thereof.
摘要翻译：本发明提供了选自N-乙酰葡糖胺，葡糖胺或其组合的氨基糖的制备方法。该方法包括在培养基中培养酵母并回收N-乙酰氨基葡萄糖，葡糖胺或其组合，其中酵母包含可操作地连接于启动子的编码葡糖胺-6-磷酸合成酶的外源核酸序列。本发明还提供一种经遗传修饰的酵母，其产生选自N-乙酰葡糖胺，葡糖胺或其组合的氨基糖。

10. 发明申请

US20080015361A1 Methods And Systems For Increasing Production of Equilibrium Reactions 失效
标题翻译：增加平衡反应生产的方法和系统
公开(公告)号：US20080015361A1
公开(公告)日：2008-01-17
申请号：US11752492
申请日：2007-05-23
申请人： Anil Khare , Brent Hilbert , Christopher Solheid , Sara McFarlan , Fernando Sanchez-Riera , Kent Floy , Paula Hicks
发明人： Anil Khare , Brent Hilbert , Christopher Solheid , Sara McFarlan , Fernando Sanchez-Riera , Kent Floy , Paula Hicks
IPC分类号： C07D209/04 , B01J8/00
CPC分类号： C07D209/20 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3804 , C12P17/10
摘要： Methods and systems for increasing the production of equilibrium reactions are described. In some embodiments, a method comprises removing enzymes from a reaction mixture once equilibrium is achieved, selectively re-adding enzymes and reactants for driving the product-forming reaction to product, and optionally recycling stabilized intermediates, by-products and/or co-products back into the reaction mixture. In some embodiments, a method comprises purifying the desired product from a reaction mixture and selectively recycling one or more components of the reaction mixture, such as original reactants, intermediates, co-products or by-products back into the reaction mixture as desired to improve titer. Systems for implementing the methods are also provided. In some embodiments the methods and systems are implemented for increasing the production of monatin and monatin derivatives, produced in multi-step equilibrium pathways.
摘要翻译：描述了用于增加平衡反应生成的方法和系统。在一些实施方案中，一种方法包括一旦达到平衡即从反应混合物中除去酶，选择性地重新加入用于将产物形成反应驱动到产物中的酶和反应物，以及任选地再循环稳定的中间体，副产物和/或副产物回到反应混合物中。在一些实施方案中，方法包括从反应混合物中纯化所需产物，并根据需要选择性地将反应混合物中的一种或多种组分（例如原始反应物，中间体，副产物或副产物）循环回到反应混合物中，以改善滴度。还提供了实施方法的系统。在一些实施方案中，实施方法和系统用于增加在多步平衡途径中产生的莫纳甜和莫纳甜衍生物的产生。

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