会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • TNF-IMMUNOCONJUGATES WITH FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF
    • 具有纤维蛋白激活蛋白抗体的TNF-免疫球蛋白及其方法及用途
    • WO2011040973A3
    • 2011-11-24
    • PCT/US2010002661
    • 2010-10-01
    • LUDWIG INST FOR CANCER RES LTDBAUER STEFANWUEST THOMASRENNER CHRISTOPH
    • BAUER STEFANWUEST THOMASRENNER CHRISTOPH
    • A61K47/48A61P35/00
    • B82Y5/00A61K47/646A61K47/66
    • Protein-immunoco?jugates are provided, particularly TNF conjugates to antibodies and fragments thereof which bind to Fibroblast Activation Protein (FAP). TNF-FAP antibody conjugates are provided wherein the FAP antibody recognizes both human and mouse FAP. These immunoconjugates are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis, and more broadly in TNF responsive conditions and disorders, including cancer and hyperproliferative diseases. In addition, the FAP-immunoconjugates can be used for the diagnosis and treatment of FAP positive tumors such as pancreatic cancer, melanoma and sarcomas. The immunoconjugates, antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof.
    • 提供蛋白质免疫缺陷蛋白,特别是与结合成纤维细胞活化蛋白(FAP)的抗体及其片段的TNF缀合物。 提供TNF-FAP抗体缀合物,其中FAP抗体识别人和小鼠FAP。 这些免疫缀合物可用于诊断和治疗与活化基质相关的病症,包括伤口愈合,上皮癌,骨关节炎,类风湿性关节炎,肝硬化和肺纤维化,更广泛地涉及TNF反应性病症和疾病,包括癌症和过度增生性疾病。 此外,FAP-免疫缀合物可用于诊断和治疗FAP阳性肿瘤如胰腺癌,黑素瘤和肉瘤。 本发明的免疫缀合物,抗体,可变区或CDR结构域序列及其片段也可用于与化学治疗剂,免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。
    • 3. 发明申请
    • TNF-IMMUNOCONJUGATES WITH FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF
    • 具有成纤维细胞活化蛋白抗体的TNF-免疫偶联物及其方法和用途
    • WO2011040973A2
    • 2011-04-07
    • PCT/US2010/002661
    • 2010-10-01
    • LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.BAUER, StefanWUEST, ThomasRENNER, Christoph
    • BAUER, StefanWUEST, ThomasRENNER, Christoph
    • A61K47/48A61P35/00
    • B82Y5/00A61K47/646A61K47/66
    • Protein-immunocoηjugates are provided, particularly TNF conjugates to antibodies and fragments thereof which bind to Fibroblast Activation Protein (FAP). TNF-FAP antibody conjugates are provided wherein the FAP antibody recognizes both human and mouse FAP. These immunoconjugates are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis, and more broadly in TNF responsive conditions and disorders, including cancer and hyperproliferative diseases. In addition, the FAP-immunoconjugates can be used for the diagnosis and treatment of FAP positive tumors such as pancreatic cancer, melanoma and sarcomas. The immunoconjugates, antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof.
    • 提供了蛋白 - 免疫偶联物,特别是与结合成纤维细胞活化蛋白(FAP)的抗体及其片段的TNF缀合物。 提供了TNF-FAP抗体偶联物,其中FAP抗体识别人和小鼠FAP。 这些免疫缀合物可用于诊断和治疗与激活的间质相关的病症,包括伤口愈合,上皮癌,骨关节炎,类风湿性关节炎,肝硬化和肺纤维化,更广泛地用于TNF反应性病症和病症,包括癌症和过度增殖性疾病。 此外,FAP-免疫缀合物可用于诊断和治疗FAP阳性肿瘤,例如胰腺癌,黑素瘤和肉瘤。 本发明的免疫缀合物,抗体,其可变区或CDR结构域序列及其片段也可以与化疗剂,免疫调节剂或抗癌剂和/或其他抗体或其片段组合用于治疗。 / p>