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1. 发明授权

US08195280B2 Method of and apparatus for classifying arrhythmias using scatter plot analysis 有权
标题翻译：使用散点图分析心律失常分类方法和设备
公开(公告)号：US08195280B2
公开(公告)日：2012-06-05
申请号：US12650893
申请日：2009-12-31
申请人： Peter M. Van Dam , Joanneke G. Groen
发明人： Peter M. Van Dam , Joanneke G. Groen
IPC分类号： A61B5/0456
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/046 , A61B5/7264 , A61N1/395 , A61N1/3956 , G06K9/00557 , Y10S128/92 , Y10S128/922 , Y10S128/923
摘要： A method of classifying arrhythmias using scatter plot analysis to define a measure of variability of a cardiac rhythm parameter such as for example, without limitation, R-R interval, A-A interval, and the slope of a portion of a cardiac signal, is disclosed. The variability measurement is derived from a scatter plot of a cardiac rhythm parameter, employing a region counting technique that quantifies the variability of the cardiac rhythm parameter while minimizing the computational complexity. The method may be employed by an implantable medical device or system, such as an implantable pacemaker or cardioverter defibrillator, or by an external device or system, such as a programmer or computer. The variability measurement may be correlated with other device or system information to differentiate between atrial flutter and atrial fibrillation, for example. The variability information may also be used by the device or system to select an appropriate therapy for a patient.
摘要翻译：公开了一种使用散点图分析来定义心律失常参数的变异性度量的方法，例如但不限于R-R间隔，A-A间隔和心脏信号的一部分的斜率。可变性测量来源于心律参数的散点图，采用区域计数技术，其量化心律参数的变异性，同时最小化计算复杂度。该方法可以由可植入的医疗装置或系统，例如可植入起搏器或心律转复除颤器，或外部设备或系统，例如编程器或计算机使用。可变性测量可以与其他装置或系统信息相关，以区分例如心房颤动和心房颤动。变异性信息也可以由装置或系统用于为患者选择适当的治疗。

2. 发明申请

US20100106035A1 METHOD OF AND APPARATUS FOR CLASSIFYING ARRHYTHMIAS USING SCATTER PLOT ANALYSIS 有权
标题翻译：使用散点图分析法分类ARRHYTHMIAS的方法和装置
公开(公告)号：US20100106035A1
公开(公告)日：2010-04-29
申请号：US12650893
申请日：2009-12-31
申请人： Peter M. Van Dam , Joanneke G. Groen
发明人： Peter M. Van Dam , Joanneke G. Groen
IPC分类号： A61B5/0456 , A61B5/0452 , A61B5/0468 , A61B5/046
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/046 , A61B5/7264 , A61N1/395 , A61N1/3956 , G06K9/00557 , Y10S128/92 , Y10S128/922 , Y10S128/923
摘要： A method of classifying arrhythmias using scatter plot analysis to define a measure of variability of a cardiac rhythm parameter such as for example, without limitation, R-R interval, A-A interval, and the slope of a portion of a cardiac signal, is disclosed. The variability measurement is derived from a scatter plot of a cardiac rhythm parameter, employing a region counting technique that quantifies the variability of the cardiac rhythm parameter while minimizing the computational complexity. The method may be employed by an implantable medical device or system, such as an implantable pacemaker or cardioverter defibrillator, or by an external device or system, such as a programmer or computer. The variability measurement may be correlated with other device or system information to differentiate between atrial flutter and atrial fibrillation, for example. The variability information may also be used by the device or system to select an appropriate therapy for a patient.
摘要翻译：公开了一种使用散点图分析来定义心律失常参数的变异性度量的方法，例如但不限于R-R间隔，A-A间隔和心脏信号的一部分的斜率。可变性测量来源于心律参数的散点图，采用区域计数技术，其量化心律参数的变异性，同时最小化计算复杂度。该方法可以由可植入的医疗装置或系统，例如可植入起搏器或心律转复除颤器，或外部设备或系统，例如编程器或计算机使用。可变性测量可以与其他装置或系统信息相关，以区分例如心房颤动和心房颤动。变异性信息也可以由装置或系统用于为患者选择适当的治疗。

3. 发明授权

US06671549B2 Pacemaker utilizing QT dynamics to diagnose heart failure 有权
标题翻译：起搏器利用QT动力学诊断心力衰竭
公开(公告)号：US06671549B2
公开(公告)日：2003-12-30
申请号：US09987796
申请日：2001-11-16
申请人： Peter M. Van Dam , Diederick M. Keizer , Mattias Rouw Rouw , Jos P. A. Smit
发明人： Peter M. Van Dam , Diederick M. Keizer , Mattias Rouw Rouw , Jos P. A. Smit
IPC分类号： A61N137
CPC分类号： A61B5/02405 , A61B5/0452 , A61B5/11 , A61B5/7285 , A61N1/365 , A61N1/3684
摘要： The invention presents a medical device system and method for determining the degree of heart failure of a patient, utilizing information representative of dynamic variations in patient QT, or segments of QT, over time. The dynamic variations in QT that are measured relate to characteristics of the variation of QT with rate when rate is increasing and when it is decreasing. The dynamic variations include QT dynamic range, QT hysteresis, and QT directrix, each providing important information relating to the patient's variation of QT with heart rate, or QT(RR). QT and dynamic variations of QT can be measured in both left and right ventricles, and taken over the patient's normal rate range. The dynamic data is measured and stored periodically and compared with historical data to determine progression toward heart failure. In another embodiment, the QRST signals are divided into segments, namely QRS width; ST segment; and T wave width, and variations of these segments are analyzed to provide additional information indicative of the patient's heart condition. Preferably the system utilizes a microprocessor programmed to carry out an algorithm that weighs detected variations in QT, QT segments and/or QT dynamic parameters with time to track cardiac changes.
摘要翻译：本发明提出了一种用于确定患者心力衰竭程度的医疗装置系统和方法，利用代表患者QT中的动态变化的信息或QT的片段随时间推移。测量的QT的动态变化与QT的变化特征有关，其速率随着速率的增加而逐渐减小。动态变化包括QT动态范围，QT滞后和QT指令，每个提供与患者QT与心率变化或QT（RR）相关的重要信息。 QT和QT的动态变化可以在左心室和右心室中测量，并且超过患者的正常速率范围。定期测量和存储动态数据，并与历史数据进行比较，以确定进展为心力衰竭。在另一个实施例中，QRST信号被分成段，即QRS宽度; ST段; 和T波宽度，并且分析这些片段的变化以提供指示患者心脏状况的附加信息。优选地，该系统利用被编程的微处理器来执行一种算法，该算法可以随时间跟踪心脏变化来重新检测QT，QT段和/或QT动态参数中的变化。

4. 发明授权

US08639326B2 Implantable medical device with ventricular pacing management of elevated heart rates 有权
标题翻译：具有升高心率的心室起搏管理的可植入医疗器械
公开(公告)号：US08639326B2
公开(公告)日：2014-01-28
申请号：US11039766
申请日：2005-01-21
申请人： Mattias Rouw , Willem Boute , Peter M. Van Dam
发明人： Mattias Rouw , Willem Boute , Peter M. Van Dam
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/3622 , A61N1/368
摘要： An implantable medical device operates to promote intrinsic ventricular depolarization according to a pacing protocol. When a cardiac rate exceeds a predetermined threshold, the implantable medical device modifies the pacing protocol parameters to promote AV synchrony.
摘要翻译：可植入医疗装置用于根据起搏方案促进内在室性去极化。当心率超过预定阈值时，可植入医疗装置修改起搏协议参数以促进AV同步。

5. 发明授权

US07542799B2 Implantable medical device with ventricular pacing protocol 有权
标题翻译：可植入医疗器械与心室起搏方案
公开(公告)号：US07542799B2
公开(公告)日：2009-06-02
申请号：US11039762
申请日：2005-01-21
申请人： Gustaaf A. P. Stoop , Willem Boute , Peter M. Van Dam , Mattias Rouw
发明人： Gustaaf A. P. Stoop , Willem Boute , Peter M. Van Dam , Mattias Rouw
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates to promote intrinsic ventricular depolarization according to a pacing protocol. The medical device determines a course of action based upon the presence or absence of sensed ventricular activity. The device further determines whether that activity is properly conducted or the result of a PVC or nodal rhythm.
摘要翻译：可植入医疗装置用于根据起搏方案促进内在室性去极化。医疗设备基于感测到的心室活动的存在或不存在来确定行动过程。该设备进一步确定该活动是否适当地进行，或者PVC或节点节奏的结果。

6. 发明授权

US07657307B2 Method of and apparatus for classifying arrhythmias using scatter plot analysis 有权
标题翻译：使用散点图分析心律失常分类方法和设备
公开(公告)号：US07657307B2
公开(公告)日：2010-02-02
申请号：US11263184
申请日：2005-10-31
申请人： Peter M. Van Dam , Joanneke G. Groen
发明人： Peter M. Van Dam , Joanneke G. Groen
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/02405 , A61B5/046 , A61B5/7264 , A61N1/395 , A61N1/3956 , G06K9/00557 , Y10S128/92 , Y10S128/922 , Y10S128/923
摘要： A method of classifying arrhythmias using scatter plot analysis to define a measure of variability of a cardiac rhythm parameter such as for example, without limitation, R-R interval, A-A interval, and the slope of a portion of a cardiac signal, is disclosed. The variability measurement is derived from a scatter plot of a cardiac rhythm parameter, employing a region counting technique that quantifies the variability of the cardiac rhythm parameter while minimizing the computational complexity. The method may be employed by an implantable medical device or system, such as an implantable pacemaker or cardioverter defibrillator, or by an external device or system, such as a programmer or computer. The variability measurement may be correlated with other device or system information to differentiate between atrial flutter and atrial fibrillation, for example. The variability information may also be used by the device or system to select an appropriate therapy for a patient.
摘要翻译：公开了一种使用散点图分析来定义心律失常参数的变异性度量的方法，例如但不限于R-R间隔，A-A间隔和心脏信号的一部分的斜率。可变性测量来源于心律参数的散点图，采用区域计数技术，其量化心律参数的变异性，同时最小化计算复杂度。该方法可以由可植入的医疗装置或系统，例如可植入起搏器或心律转复除颤器，或外部设备或系统，例如编程器或计算机使用。可变性测量可以与其他装置或系统信息相关，以区分例如心房颤动和心房颤动。变异性信息也可以由装置或系统用于为患者选择适当的治疗。

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