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1. 发明申请

WO2008152142A1 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES 审中-公开
标题翻译： 2-氨基喹啉衍生物及其治疗用途
公开(公告)号：WO2008152142A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/057510
申请日：2008-06-13
申请人： SoftCure Pharmaceuticals AB , HALLBERG, Anders , WESTMAN, Jacob , POST, Claes
发明人： HALLBERG, Anders , WESTMAN, Jacob , POST, Claes
IPC分类号： C07D239/95 , C07D407/12 , A61K31/517 , A61P29/00 , A61P35/00 , A61P17/06 , A61P11/06
CPC分类号： C07D239/95 , C07D407/12
摘要： A compound of formula (I) wherein X is NH 2 or OH and W is -C(O)-O- or -O-C(O)-; use thereof as a medicament, in particular for the treatment of inflammation, autoimmune disorder, immunogenic rejection reactions and cancer and for non-surgical abortion.
摘要翻译：式（I）的化合物，其中X为NH 2或OH且W为-C（O）-O-或-O-C（O） - ; 其用途，特别是用于治疗炎症，自身免疫疾病，免疫原性排斥反应和癌症以及用于非手术流产。

2. 发明申请

WO2005097174A3 USES OF A COMBINATION OF GHRELIN AND SOMATOTROPIN FOR THE TREATMENT OF CACHEXIA 审中-公开
标题翻译：使用GHRELIN和SOMATOTROPIN治疗CACHEXIA
公开(公告)号：WO2005097174A3
公开(公告)日：2005-12-29
申请号：PCT/DK2005000242
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , POST CLAES , ISAKSSON OLOF GUSTAV PAULUS , NIELSEN TINA GERITZ
发明人： LANGE BIRGITTE HOLST , POST CLAES , ISAKSSON OLOF GUSTAV PAULUS , NIELSEN TINA GERITZ
IPC分类号： A61K38/24 , A61K38/25 , A61K38/27 , A61K38/35 , A61P3/00
CPC分类号： A61K38/35 , A61K38/24 , A61K38/25 , A61K38/27 , A61K2300/00
摘要： The present invention relates to the use of a secretagogue, such as a ghrelin-like compound, in combination with a growth hormone, such as somatotropin or a variant thereof, for the production of a medicament for the treatment of an individual in need thereof, and to a method of treating or preventing cachexia, stimulating appetite, food intake and/or weight gain in an individual in need thereof by administering a ghrelin-like compound. Furthermore, the invention relates to pharmaceutical compositions comprising at least one secretagogue and at least one growth hormone, and medical packagings comprising one or more of said pharmaceutical composition. In another aspect, the present invention relates to a method of treating an individual in need thereof, such as an individual suffering from cachexia, by administering at least one secretagogue, such as a ghrelin-like compound, in combination with at least one growth hormone.
摘要翻译：本发明涉及促分泌素如生长素释放肽样化合物与生长激素如生长激素或其变体的组合在制备用于治疗有需要的个体的药物中的用途，以及通过施用生长素释放肽样化合物来治疗或预防有需要的个体的恶病质，刺激食欲，摄食和/或体重增加的方法。此外，本发明涉及包含至少一种促分泌素和至少一种生长激素的药物组合物和包含一种或多种所述药物组合物的医用包装。另一方面，本发明涉及通过将至少一种促分泌素如生长素释放肽样化合物与至少一种生长激素组合来治疗有需要的个体，例如患有恶病质的个体的方法。

3. 发明申请

WO2009035387A1 A MEDICAMENT PREPARED USING METHOTREXATE AND SUITABLE FOR TOPICAL ADMINISTRATION, FOR THE TREATMENT OF A LOWER GASTROINTESTINAL TRACT INFLAMMATORY DISEASE 审中-公开
标题翻译：使用甲基异黄酮制剂并适用于局部给药的药物，用于治疗下胃肠道炎症性炎症疾病
公开(公告)号：WO2009035387A1
公开(公告)日：2009-03-19
申请号：PCT/SE2007/050651
申请日：2007-09-14
申请人： SoftCure Pharmaceuticals AB , HALLBERG, Anders , POST, Claes , HELLSTRÖM, Per , LUNDBERG, Sofie
发明人： HALLBERG, Anders , POST, Claes , HELLSTRÖM, Per , LUNDBERG, Sofie
IPC分类号： A61K31/519 , A61P1/00 , A61K9/10
CPC分类号： A61K9/0014 , A61K9/0031 , A61K9/006 , A61K31/519 , A61K47/38
摘要： Use of methotrexate in the preparation of a medicament for the treatment of a lower gastrointestinal tract inflammatory disease in a mammal by topical administration to the lower gastrointestinal tract of said mammal. A method of treatment of a lower gastrointestinal tract inflammatory disease by topical administration of a therapeutically effect ive dose of methotrexate to the lower gastrointestinal tract of a mammal in need of such treatment. A medicament for topical administration containing methotrexate.
摘要翻译：在制备用于通过局部给予所述哺乳动物的下胃肠道的哺乳动物中治疗下胃肠道炎性疾病的药物中的用途。通过局部给予需要这种治疗的哺乳动物的下胃肠道的治疗效果的甲氨蝶呤治疗下胃肠道炎症性疾病的方法。一种用于局部给药的药物，其含有甲氨蝶呤。

4. 发明申请

WO2005097173A3 USE OF GHRELIN FOR THE TREATMENT OF HYPERTHYROIDISM 审中-公开
标题翻译：使用GHRELIN治疗高血糖症
公开(公告)号：WO2005097173A3
公开(公告)日：2005-12-29
申请号：PCT/DK2005000237
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS , NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
发明人： NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
IPC分类号： A61K38/25 , A61P3/00 , A61P5/14
CPC分类号： A61K38/25
摘要： The present invention relates to the use of a growth hormone (GH) secretagogue, such as a ghrelin-like compound, for the preparation of a medicament for the prophylaxis or treatment of ghrelin deficiency, and/or undesirable symptoms associated therewith, in an individual at risk of acquiring partial or complete ghrelin deficiency resulting from a medical treatment and/or from a pathological condition. The present invention also relates to use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of one or more of: loss of fat mass, loss of lean body mass, weight loss, cachexia, loss of appetite, immunological dysfunction, malnutrition, disrupted sleep pattern, sleepiness, reduction in intestinal absorption and/or intestinal mobility problems in an individual suffering from, or at risk of suffering from, ghrelin deficiency. Furthermore, the present invention relates to the use of a secretagogue, such as a ghrelin-like compound, for the production of a medicament for preventing weight increase in an individual either: a) being converted from a hyperthyroidic state to euthyroid state, or b) in remission from being converted from a hyperthyroidic state to euthyroid state.
摘要翻译：本发明涉及生长激素（GH）促分泌素如生长素释放肽样化合物在个体中用于预防或治疗生长素释放肽缺乏症和/或与之相关的不良症状的药物的用途有获得由医疗和/或病理状况引起的部分或完全的生长素释放肽缺乏的风险。本发明还涉及促分泌素化合物在制备用于预防或治疗以下中的一种或多种的药物中的用途：脂肪量的损失，瘦体重的减少，体重减轻，恶病质，食欲不振，免疫功能障碍，营养不良，睡眠模式紊乱，困倦，减少肠道吸收和/或肠道运动问题，或者有遭受生长素释放肽缺乏症的个体。此外，本发明涉及促分泌素如生长素释放肽样化合物在制备用于预防个体体重增加的药物中的用途：a）从甲状腺功能亢进状态转变为甲状腺功能状态，或b ）缓解从甲状腺功能亢进状态转变为甲状腺功能状态。

5. 发明申请

WO2005097173A2 USE OF A SECRETAGOGUE FOR THE TREATMENT OF GHRELIN DEFICIENCY 审中-公开
标题翻译：使用秘密治疗GHRELIN缺乏症
公开(公告)号：WO2005097173A2
公开(公告)日：2005-10-20
申请号：PCT/DK2005/000237
申请日：2005-04-07
申请人： GASTROTECH PHARMA A/S , NILSSON, Henrik , LANGE, Birgitte, Holst , POST, Claes , NIELSEN, Tina, Geritz
发明人： NILSSON, Henrik , LANGE, Birgitte, Holst , POST, Claes , NIELSEN, Tina, Geritz
IPC分类号： A61K38/25
CPC分类号： A61K38/25
摘要： The present invention relates to the use of a growth hormone (GH) secretagogue, such as a ghrelin-like compound, for the preparation of a medicament for the prophylaxis or treatment of ghrelin deficiency, and/or undesirable symptoms associated therewith, in an individual at risk of acquiring partial or complete ghrelin deficiency resulting from a medical treatment and/or from a pathological condition. The present invention also relates to use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of one or more of: loss of fat mass, loss of lean body mass, weight loss, cachexia, loss of appetite, immunological dysfunction, malnutrition, disrupted sleep pattern, sleepiness, reduction in intestinal absorption and/or intestinal mobility problems in an individual suffering from, or at risk of suffering from, ghrelin deficiency. Furthermore, the present invention relates to the use of a secretagogue, such as a ghrelin-like compound, for the production of a medicament for preventing weight increase in an individual either: a) being converted from a hyperthyroidic state to euthyroid state, or b) in remission from being converted from a hyperthyroidic state to euthyroid state.
摘要翻译：本发明涉及生长激素（GH）促分泌素如生长素释放肽样化合物在个体中用于预防或治疗生长素释放肽缺乏症和/或与之相关的不良症状的药物的用途有获得由医疗和/或病理状况引起的部分或完全的生长素释放肽缺乏的风险。本发明还涉及促分泌素化合物在制备用于预防或治疗以下中的一种或多种的药物中的用途：脂肪量的损失，瘦体重的减少，体重减轻，恶病质，食欲不振，免疫功能障碍，营养不良，睡眠模式紊乱，困倦，减少肠道吸收和/或肠道运动问题，或者有遭受生长素释放肽缺乏症的个体。此外，本发明涉及促分泌素如生长素释放肽样化合物在制备用于预防个体体重增加的药物中的用途：a）从甲状腺功能亢进状态转变为甲状腺功能状态，或b ）缓解从甲状腺功能亢进状态转变为甲状腺功能状态。

6. 发明申请

WO1990000390A1 NEW SYNERGISTIC PREPARATIONS CONTAINING DEZOCINE AND A LOCAL ANAESTHETIC AND A NEW METHOD OF ALLEVIATION OF PAIN 审中-公开
标题翻译：含有DEZOCINE和本地麻醉剂的新型协同制剂和一种新的疼痛评估方法
公开(公告)号：WO1990000390A1
公开(公告)日：1990-01-25
申请号：PCT/SE1989000348
申请日：1989-06-19
申请人： AKTIEBOLAGET ASTRA , POST, Claes, Tomas
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61K31/135
CPC分类号： A61K31/7004 , A61K31/445 , A61K31/13 , A61K31/135 , A61K2300/00
摘要： A pharmaceutical preparation for spinal analgesia, which alleviates postoperative or chronic pain containing dezocine or a physiologically acceptable salt thereof together with a local anaesthetic, such as bupivacaine or a physiologically acceptable salt thereof, a method for obtaining said preparation and a method of obtaining analgesia by administering said preparation to a patient in the need of analgesia.
摘要翻译：一种用于脊髓止痛的药物制剂，其与含有替佐啶或其生理学上可接受的盐的局部麻醉剂如布比卡因或其生理学上可接受的盐一起减轻术后或慢性疼痛，获得所述制剂的方法和通过以下步骤获得镇痛的方法：对需要镇痛的患者给予所述制剂。

7. 发明申请

WO2005097174A2 USES OF COMBINATIONS OF A GH SECRETAGOGUE AND A GROWTH HORMONE 审中-公开
标题翻译：使用GH密封胶和生长激素的组合
公开(公告)号：WO2005097174A2
公开(公告)日：2005-10-20
申请号：PCT/DK2005/000242
申请日：2005-04-07
申请人： GASTROTECH PHARMA A/S , LANGE, Birgitte Holst , POST, Claes , ISAKSSON, Olof Gustav Paulus , NIELSEN, Tina Geritz
发明人： LANGE, Birgitte Holst , POST, Claes , ISAKSSON, Olof Gustav Paulus , NIELSEN, Tina Geritz
IPC分类号： A61K38/25
CPC分类号： A61K38/35 , A61K38/24 , A61K38/25 , A61K38/27 , A61K2300/00
摘要： The present invention relates to the use of a secretagogue, such as a ghrelin-like compound, in combination with a growth hormone, such as somatotropin or a variant thereof, for the production of a medicament for the treatment of an individual in need thereof, and to a method of treating or preventing cachexia, stimulating appetite, food intake and/or weight gain in an individual in need thereof by administering a ghrelin-like compound. Furthermore, the invention relates to pharmaceutical compositions comprising at least one secretagogue and at least one growth hormone, and medical packagings comprising one or more of said pharmaceutical composition. In another aspect, the present invention relates to a method of treating an individual in need thereof, such as an individual suffering from cachexia, by administering at least one secretagogue, such as a ghrelin-like compound, in combination with at least one growth hormone.
摘要翻译：本发明涉及促分泌素如生长素释放肽样化合物与生长激素如生长激素或其变体的组合在制备用于治疗有需要的个体的药物中的用途，以及通过施用生长素释放肽样化合物来治疗或预防有需要的个体的恶病质，刺激食欲，摄食和/或体重增加的方法。此外，本发明涉及包含至少一种促分泌素和至少一种生长激素的药物组合物和包含一种或多种所述药物组合物的医用包装。另一方面，本发明涉及通过将至少一种促分泌素如生长素释放肽样化合物与至少一种生长激素组合来治疗有需要的个体，例如患有恶病质的个体的方法。

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