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1. 实用新型

TWM499522U 多功能燈具構造失效
简体标题：多功能灯具构造
公开(公告)号：TWM499522U
公开(公告)日：2015-04-21
申请号：TW103216970
申请日：2014-09-24
申请人：潘靜怡 , PAN, JING YI , 和春技術學院 , FORTUNE INSTITUTE OF TECHNOLOGY
发明人：潘靜怡 , PAN, JING YI , 莊嘉慶 , CHUANG, CHIA CHING
IPC分类号： F21V3/02 , F21W131/30

2. 实用新型

TW557647U Adjustable stationary floating-body assembly structure 失效
公开(公告)号：TW557647U
公开(公告)日：2003-10-11
申请号：TW91212392
申请日：2002-08-09
申请人： PAN JING-YI
发明人： PAN JING-YI
IPC分类号： A01K61/00
CPC分类号： Y02A40/81

3. 发明申请

WO2013020005A2 OXAZOLINE POLYMER COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：恶唑啉聚合物组合物及其用途
公开(公告)号：WO2013020005A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/049410
申请日：2012-08-03
申请人： ANP TECHNOLOGIES, INC. , YIN, Ray , PAN, Jing , QIN, Dujie , ZHANG, Yubei
发明人： YIN, Ray , PAN, Jing , QIN, Dujie , ZHANG, Yubei
IPC分类号： C08G73/06 , C08G81/00 , C08L79/04 , A61K47/48
CPC分类号： C08G69/48 , A61K31/4745 , A61K31/7068 , A61K47/50 , A61K47/51 , A61K47/54 , A61K47/55 , A61K47/56 , A61K47/59 , A61K47/595 , A61K47/6807 , A61K47/6883 , C08G73/0233 , C08G73/028 , C08G81/00 , C08G83/004 , G01N33/545
摘要： Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.
摘要翻译：包含恶唑啉聚合物和任选的连接子以携带各种分子的组合物。

4. 发明申请

WO2011163647A2 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF HEPARAN N-SULFATASE 审中-公开
标题翻译：用于中枢神经系统递送HEPARAN N-SULFATASE的方法和组合物
公开(公告)号：WO2011163647A2
公开(公告)日：2011-12-29
申请号：PCT/US2011041922
申请日：2011-06-25
申请人： SHIRE HUMAN GENETIC THERAPIES , NATOLI FARAH , ZHU GAOZHONG , TEREW JENNIFER , JIANG YUAN , TSUNG JAMIE , SHAHROKH ZAHRA , VERNAGLIA BRIAN , PAN JING , PFEIFER RICHARD , CALIAS PERICLES
发明人： NATOLI FARAH , ZHU GAOZHONG , TEREW JENNIFER , JIANG YUAN , TSUNG JAMIE , SHAHROKH ZAHRA , VERNAGLIA BRIAN , PAN JING , PFEIFER RICHARD , CALIAS PERICLES
IPC分类号： A61K38/47 , A61P25/00 , A61P25/28
CPC分类号： A61K9/0085 , A61K9/0019 , A61K9/19 , A61K38/465 , A61K47/02 , A61K47/26 , C12N9/14 , C12N9/2402 , C12Y302/0105 , C12Y310/01001
摘要： The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.
摘要翻译：本发明尤其提供了用于CNS递送溶酶体酶以有效治疗溶酶体贮积病的组合物和方法。在一些实施方案中，本发明包括用于直接CNS鞘内施用的稳定制剂，其包含用于治疗Sanfilippo综合征A型的肝素N-硫酸酯酶（HNS）蛋白质，盐和聚山梨醇酯表面活性剂。

5. 发明申请

WO2013020005A3 OXAZOLINE POLYMER COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译： OXAZOLINE聚合物组合物及其用途
公开(公告)号：WO2013020005A3
公开(公告)日：2013-04-11
申请号：PCT/US2012049410
申请日：2012-08-03
申请人： ANP TECHNOLOGIES INC , YIN RAY , PAN JING , QIN DUJIE , ZHANG YUBEI
发明人： YIN RAY , PAN JING , QIN DUJIE , ZHANG YUBEI
IPC分类号： C08G73/06 , A61K47/48 , C08G81/00 , C08L79/04
CPC分类号： A61K47/48192 , A61K31/4745 , A61K31/7068 , A61K47/48207 , A61K47/484 , A61K47/59 , A61K47/595 , A61K47/6807 , C08G69/48 , C08G73/0233 , C08G81/00 , C08G83/004 , G01N33/545
摘要： Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.
摘要翻译：包含恶唑啉聚合物和任选的接头以携带各种分子的组合物。

6. 发明申请

WO2011163648A8 CNS DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：中枢神经系统递送治疗药物
公开(公告)号：WO2011163648A8
公开(公告)日：2013-01-03
申请号：PCT/US2011041924
申请日：2011-06-25
申请人： SHIRE HUMAN GENETIC THERAPIES , CALIAS PERICLES , PAN JING , POWELL JAN , CHARNAS LAWRENCE , MCCAULEY THOMAS , WRIGHT TERESA LEAH , PFEIFER RICHARD , SHAHROKH ZAHRA
发明人： CALIAS PERICLES , PAN JING , POWELL JAN , CHARNAS LAWRENCE , MCCAULEY THOMAS , WRIGHT TERESA LEAH , PFEIFER RICHARD , SHAHROKH ZAHRA
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , A61K9/0085 , A61K9/19 , A61K35/76 , A61K35/761 , A61K38/47 , C12N9/2402 , C12Y301/06013 , C12Y302/01045 , C12Y302/0105
摘要： The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.
摘要翻译：本发明提供了用于将治疗剂直接递送至中枢神经系统（CNS）的有效且较少侵入性的方法。在一些实施方案中，本发明提供了包括以下步骤的方法：鞘内施用患有或易受溶酶体酶降低的水平或活性的溶酶体贮积病的受试者，包含溶酶体酶的置换酶的组合物。

7. 发明申请

WO2012094620A2 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
标题翻译：疏水性分子引发的支化聚合物聚集体及其应用
公开(公告)号：WO2012094620A2
公开(公告)日：2012-07-12
申请号：PCT/US2012020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC , DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
发明人： DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K47/48 , A61K49/04 , A61K49/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
摘要翻译：对称和不对称支化均聚物在表面水平被官能团改性，所述官能团能够与水不溶性或水溶性差的药物活性剂（PAA）形成聚集体。形成的聚集体由PAA和均聚物的相互作用特异性诱导，并且不同于不存在PAA时单独由聚合物形成的聚集体或不存在聚合物时由单独PAA形成的聚集体。这种聚集体可用于改善药物的溶解性，稳定性，递送和功效。

8. 发明申请

WO0229358A9 IN-SITU THICKNESS AND REFRACTIVE INDEX MONITORING AND CONTROL SYSTEM FOR THIN FILM DEPOSITION 审中-公开
标题翻译：薄膜沉积的现场厚度和折射率指数监测和控制系统
公开(公告)号：WO0229358A9
公开(公告)日：2002-10-17
申请号：PCT/US0131026
申请日：2001-10-04
申请人： OPNETICS CORP , ZHANG JIAN , PAN JING
发明人： ZHANG JIAN , PAN JING
IPC分类号： G01B11/06 , G01N21/39 , G01N21/41 , G01N21/59 , G01N21/84
CPC分类号： G01N21/4133 , G01B11/0625 , G01B11/0683 , G01N21/39 , G01N21/41 , G01N21/59 , G01N21/8422
摘要： A method of determining thickness and refractive index of an optical thin film is described. The method includes generating a diagnostic light beam having a first and a second wavelength. The method also includes measuring unattenuated light intensities at the first and the second wavelength of the diagnostic light beam. The method also includes measuring attenuated light intensities at the first and the second wavelength of the diagnostic light beam after transmission through the optical thin film. A null light intensity for the diagnostic light beam at the first and second wavelength is also determined. A first and second normalized intensity function is determined using the measured unattenuated light intensities, the measured attenuated light intensities, and the measured null light intensities. The thickness and refractive index of the optical thin film is then determined by solving the first and second normalized intensity function for thickness and refractive index.
摘要翻译：描述了确定光学薄膜的厚度和折射率的方法。该方法包括产生具有第一和第二波长的诊断光束。该方法还包括在诊断光束的第一和第二波长处测量未衰减的光强度。该方法还包括在通过光学薄膜传输之后测量诊断光束的第一和第二波长处的衰减光强度。还确定了在第一和第二波长处的诊断光束的零光强度。使用测量的非衰减光强度，测量的衰减光强度和测量的零光强度来确定第一和第二归一化强度函数。然后通过求解厚度和折射率的第一和第二归一化强度函数来确定光学薄膜的厚度和折射率。

9. 发明申请

WO2011163650A3 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF ARYLSULFATASE A 审中-公开
标题翻译：中枢神经系统递送ARYLSULFATASE的方法和组合物A
公开(公告)号：WO2011163650A3
公开(公告)日：2013-06-13
申请号：PCT/US2011041926
申请日：2011-06-25
申请人： SHIRE HUMAN GENETIC THERAPIES , SALAMAT-MILLER NAZILA , TAYLOR KATHERINE , CAMPOLIETO PAUL , SHAHROKH ZAHRA , PAN JING , CHARNAS LAWRENCE , WRIGHT TERESA LEAH , CALIAS PERICLES
发明人： SALAMAT-MILLER NAZILA , TAYLOR KATHERINE , CAMPOLIETO PAUL , SHAHROKH ZAHRA , PAN JING , CHARNAS LAWRENCE , WRIGHT TERESA LEAH , CALIAS PERICLES
IPC分类号： A61K38/54 , A61K38/46
CPC分类号： A61K9/0085 , A61K9/0019 , A61K9/19 , A61K38/465 , A61K47/02 , A61K47/26 , C12Y301/06013
摘要： Compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases are provided. A stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease is disclosed.
摘要翻译：提供了CNS递送用于有效治疗溶酶体贮积病的溶酶体酶的组合物和方法。公开了用于直接CNS鞘内施用的稳定制剂，其包含芳基硫酸酯酶A（ASA）蛋白质，盐和用于治疗间质性白血病淋巴细胞减少症的聚山梨醇酯表面活性剂。

10. 发明申请

WO2012094620A9 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
公开(公告)号：WO2012094620A9
公开(公告)日：2012-07-12
申请号：PCT/US2012/020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES, INC. , DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
发明人： DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
IPC分类号： A61K47/30 , A61K49/06 , A61K49/04 , A61K47/48
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.

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