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1. 发明授权

US07402567B2 Treatment of disease by inducing cell apoptosis 失效
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US07402567B2
公开(公告)日：2008-07-22
申请号：US10415325
申请日：2001-10-26
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/00 , A61K38/43 , C07K14/00
CPC分类号： A61K38/1709
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在特别优选的实施方案中，本发明提供诱导纤维化的组合物和方法。

2. 发明授权

US06495335B2 Compositions and methods for diagnosing alzheimer's disease 有权
标题翻译：用于诊断阿尔茨海默病的组合物和方法
公开(公告)号：US06495335B2
公开(公告)日：2002-12-17
申请号：US09731460
申请日：2000-12-07
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for the diagnosis of Alzheimer's disease. In particular, the present invention provides modified beta-amyloid peptides, antibodies that specifically bind to the modified beta-amyloid peptides, and methods for using these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of Alzheimer's disease in patients. The present invention also provides compositions and methods useful in research involving amyloid precursor protein (APP) metabolism and Alzheimer's disease.
摘要翻译：本发明提供了用于诊断阿尔茨海默病的方法和组合物。特别地，本发明提供了修饰的β-淀粉样蛋白肽，与修饰的β-淀粉样蛋白肽特异性结合的抗体，以及使用这些组合物来诊断阿尔茨海默氏病的方法，以及监测治疗和/或疾病进展的方法的阿尔茨海默病。本发明还提供了用于涉及淀粉样蛋白前体蛋白（APP）代谢和阿尔茨海默病的研究中的组合物和方法。

3. 发明授权

US06811988B2 Compositions and methods for diagnosing Alzheimer's disease 失效
标题翻译：用于诊断阿尔茨海默病的组合物和方法
公开(公告)号：US06811988B2
公开(公告)日：2004-11-02
申请号：US10278181
申请日：2002-10-21
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： C12P1900
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for the diagnosis of Alzheimer's disease. In particular, the present invention provides modified beta-amyloid peptides, antibodies that specifically bind to the modified beta-amyloid peptides, and methods for using these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of Alzheimer's disease in patients. The present invention also provides compositions and methods useful in research involving amyloid precursor protein (APP) metabolism and Alzheimer's disease.
摘要翻译：本发明提供了用于诊断阿尔茨海默病的方法和组合物。特别地，本发明提供了修饰的β-淀粉样蛋白肽，与修饰的β-淀粉样蛋白肽特异性结合的抗体，以及使用这些组合物来诊断阿尔茨海默氏病的方法，以及监测治疗和/或疾病进展的方法的阿尔茨海默病。本发明还提供了用于涉及淀粉样蛋白前体蛋白（APP）代谢和阿尔茨海默病的研究中的组合物和方法。

4. 发明授权

US5922757A Treatment and prevention of hepatic disorders 失效
公开(公告)号：US5922757A
公开(公告)日：1999-07-13
申请号：US723052
申请日：1996-09-30
申请人： Mario Chojkier
发明人： Mario Chojkier
IPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , C07D311/04
CPC分类号： A61K31/355 , A61K31/05 , A61K31/522 , Y10S514/893 , Y10S514/894
摘要： New methods are described for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-�3-carboxypropyl!-3, 7-dimethylxanthine.

5. 发明申请

US20100035825A1 Treatment Of Disease By Inducing Cell Apoptosis 有权
标题翻译：通过诱导细胞凋亡来治疗疾病
公开(公告)号：US20100035825A1
公开(公告)日：2010-02-11
申请号：US12189526
申请日：2008-08-11
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/07 , A61P35/00
CPC分类号： A61K38/07
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In some preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In some particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis. In still further embodiments, the present invention provides methods and compositions to treat and/or prevent cancer.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在一些优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在一些特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。在另外的实施方案中，本发明提供了治疗和/或预防癌症的方法和组合物。

6. 发明授权

US07655472B2 Treatment of disease by inducing cell apoptosis 失效
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US07655472B2
公开(公告)日：2010-02-02
申请号：US12166907
申请日：2008-07-02
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： G01N33/00 , C07K16/00 , C07K17/00 , C07K5/00 , C07K14/00 , C07K2/00 , C07K4/00
CPC分类号： A61K38/1709
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。

7. 发明授权

US06348493B1 Treatment and prevention of hepatic disorders 失效
标题翻译：治疗和预防肝功能障碍
公开(公告)号：US06348493B1
公开(公告)日：2002-02-19
申请号：US09724594
申请日：2000-11-28
申请人： Mario Chojkier
发明人： Mario Chojkier
IPC分类号： A61K3121
CPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , Y10S514/894
摘要： The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine. Furthermore, new methods are described for the treatment and prevention of hepatic disorders involving the use of 2,6-di-tert-butylphenol derivatives.
摘要翻译：本发明提供了用于治疗病毒性丙型肝炎的新方法，涉及维生素E和具有抗氧化性质的其它化合物的给药。用高剂量的维生素E治疗可有效治疗难治性干扰素患者的慢性丙型肝炎。此外，描述了治疗肝纤维化和表现肝纤维化的肝脏病症的新方法，涉及施用丁基化羟基甲苯和己酮可可碱1- [3-羧基丙基] -3,7-二甲基黄嘌呤的代谢物。此外，描述了用于治疗和预防涉及使用2,6-二叔丁基苯酚衍生物的肝脏疾病的新方法。

8. 发明授权

US6147123A Treatment and prevention of hepatic disorders 失效
公开(公告)号：US6147123A
公开(公告)日：2000-11-14
申请号：US274624
申请日：1999-03-23
申请人： Mario Chojkier , Dennis Carson
发明人： Mario Chojkier , Dennis Carson
IPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , C07C39/04
CPC分类号： A61K31/355 , A61K31/05 , A61K31/522 , Y10S514/893 , Y10S514/894
摘要： New methods are described for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine.

9. 发明授权

US08129349B2 Treatment of disease by inducing cell apoptosis 有权
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US08129349B2
公开(公告)日：2012-03-06
申请号：US12189526
申请日：2008-08-11
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/07
CPC分类号： A61K38/07
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In some preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In some particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis. In still further embodiments, the present invention provides methods and compositions to treat and/or prevent cancer.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在一些优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在一些特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。在另外的实施方案中，本发明提供了治疗和/或预防癌症的方法和组合物。

10. 发明申请

US20090069537A1 Treatment Of Disease By Inducing Cell Apoptosis 失效
标题翻译：通过诱导细胞凋亡来治疗疾病
公开(公告)号：US20090069537A1
公开(公告)日：2009-03-12
申请号：US12166907
申请日：2008-07-02
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： C07K5/08
CPC分类号： A61K38/1709
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。

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