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1. 发明授权

US08822755B2 Genetic markers associated with drought tolerance in maize 有权
标题翻译：与玉米耐旱性相关的遗传标记
公开(公告)号：US08822755B2
公开(公告)日：2014-09-02
申请号：US12977996
申请日：2010-12-23
申请人： Venkata Krishna Kishore , Paul Altendorf , Thomas Joseph Prest , Chris Zinselmeier , Daolong Wang , William Briggs , Sonali Gandhi , David Foster , Christine Chaulk-Grace , Joseph Dallas Clarke, V , Allen Sessions , Kari Denise Kust , Jon Aaron Tucker Reinders , Libardo Andres Gutierrez Rojas , Meijuan Li , Todd Warner , Nicolas Martin , Robert Lynn Miller , John Arbuckle , Dale Wayne Skalla , Molly Dunn , Gayle Dace , Vance Cary Kramer
发明人： Venkata Krishna Kishore , Paul Altendorf , Thomas Joseph Prest , Chris Zinselmeier , Daolong Wang , William Briggs , Sonali Gandhi , David Foster , Christine Chaulk-Grace , Joseph Dallas Clarke, V , Allen Sessions , Kari Denise Kust , Jon Aaron Tucker Reinders , Libardo Andres Gutierrez Rojas , Meijuan Li , Todd Warner , Nicolas Martin , Robert Lynn Miller , John Arbuckle , Dale Wayne Skalla , Molly Dunn , Gayle Dace , Vance Cary Kramer
IPC分类号： A01H1/02 , A01H5/10 , C12Q1/68 , A01H1/04
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/8274 , C12N15/8275 , C12N15/8278 , C12N15/8282 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172 , Y02A40/132
摘要： The presently disclosed subject matter relates to methods and compositions for identifying, selecting, and/or producing drought tolerant maize plants or germplasm. Maize plants or germplasm that have been identified, selected, and/or produced by any of the methods of the presently disclosed subject matter are also provided.
摘要翻译：目前公开的主题涉及用于鉴定，选择和/或产生耐旱玉米植物或种质的方法和组合物。还提供已经通过本公开主题的任何方法鉴定，选择和/或生产的玉米植物或种质。

2. 发明申请

US20110214200A1 YIELD TRAITS FOR MAIZE 审中-公开
标题翻译：玉米产地
公开(公告)号：US20110214200A1
公开(公告)日：2011-09-01
申请号：US12904450
申请日：2010-10-14
申请人： DAOLONG WANG , LIBARDO ANDRES GUTIERREZ ROJAS , XI CHEN , JOSEPH CLARKE , MICHAEL G. MUSZYNSKI , PAUL ALTENDORF , SARAH ALISSA FORRESTER , LYNN SENIOR , VENKATA KRISHNA KISHORE
发明人： DAOLONG WANG , LIBARDO ANDRES GUTIERREZ ROJAS , XI CHEN , JOSEPH CLARKE , MICHAEL G. MUSZYNSKI , PAUL ALTENDORF , SARAH ALISSA FORRESTER , LYNN SENIOR , VENKATA KRISHNA KISHORE
IPC分类号： A01H1/02 , C12Q1/68 , C12N5/04 , A01H5/00 , A01H5/10 , C07H21/04
CPC分类号： C12N15/8261 , A01H1/02 , A01H1/04 , A01H5/10 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156
摘要： Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
摘要翻译：提供了将与产量性状相关的基因座感兴趣等位基因浸入玉米种质的方法。在一些实施方案中，所述方法包括提供包含与产量性状相关的基因座的目的等位基因的玉米种植体，其中与产量性状相关的基因座可通过具有一对玉米的玉米核酸的PCR扩增来鉴定寡核苷酸引物，并将感兴趣的等位基因渗入缺少等位基因的玉米种质。还提供了用于鉴定含有至少一个与改良产量相关的等位基因的Zea mays植物的方法，改良的玉米植物，精英玉米植物，由改良的Zea mays植物产生的生物，分离和纯化的遗传标记，以及包含扩增引物能够扩增Zea mays核酸以产生Zea mays标记扩增子。

3. 发明申请

US20110191892A1 GENETIC MARKERS ASSOCIATED WITH DROUGHT TOLERANCE IN MAIZE 有权
标题翻译：遗传标记与玉米耐旱性相关
公开(公告)号：US20110191892A1
公开(公告)日：2011-08-04
申请号：US12977996
申请日：2010-12-23
申请人： Venkata Krishna Kishore , Paul Altendorf , Thomas Joseph Prest , Chris Zinselmeier , Daolong Wang , William Briggs , Sonali Gandhi , David Foster , Christine Chaulk-Grace , Joseph Dallas Clarke, V , Allen Sessions , Kari Denise Kust , Jon Aaron Tucker Reinders , Libardo Andres Gutierrez Rojas , Meijuan Li , Todd Warner , Nicolas Martin , Robert Lynn Miller , John Arbuckle , Dale Wayne Skalla
发明人： Venkata Krishna Kishore , Paul Altendorf , Thomas Joseph Prest , Chris Zinselmeier , Daolong Wang , William Briggs , Sonali Gandhi , David Foster , Christine Chaulk-Grace , Joseph Dallas Clarke, V , Allen Sessions , Kari Denise Kust , Jon Aaron Tucker Reinders , Libardo Andres Gutierrez Rojas , Meijuan Li , Todd Warner , Nicolas Martin , Robert Lynn Miller , John Arbuckle , Dale Wayne Skalla
IPC分类号： A01H1/02 , A01H5/00 , C12N5/04 , C12Q1/68
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/8274 , C12N15/8275 , C12N15/8278 , C12N15/8282 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172 , Y02A40/132
摘要： The presently disclosed subject matter relates to methods and compositions for identifying, selecting, and/or producing drought tolerant maize plants or germplasm. Maize plants or germplasm that have been identified, selected, and/or produced by any of the methods of the presently disclosed subject matter are also provided.
摘要翻译：目前公开的主题涉及用于鉴定，选择和/或产生耐旱玉米植物或种质的方法和组合物。还提供已经通过本公开主题的任何方法鉴定，选择和/或生产的玉米植物或种质。

4. 发明授权

US08809621B2 Yield traits for maize 有权
标题翻译：玉米产量性状
公开(公告)号：US08809621B2
公开(公告)日：2014-08-19
申请号：US12536147
申请日：2009-08-05
申请人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
发明人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
IPC分类号： A01H1/02 , A01H5/10
CPC分类号： A01H1/04 , A01H3/00 , A01H5/10 , C12N15/8261 , C12Q1/6895 , C12Q2600/13
摘要： Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
摘要翻译：提供了将与产量性状相关的基因座感兴趣等位基因浸入玉米种质的方法。在一些实施方案中，所述方法包括提供包含与产量性状相关的基因座的目的等位基因的玉米种植体，其中与产量性状相关的基因座可通过具有一对玉米的玉米核酸的PCR扩增来鉴定寡核苷酸引物，并将感兴趣的等位基因渗入缺少等位基因的玉米种质。还提供了用于鉴定含有至少一个与改良产量相关的等位基因的Zea mays植物的方法，改良的玉米植物，精英玉米植物，由改良的Zea mays植物产生的生物，分离和纯化的遗传标记，以及包含扩增引物能够扩增Zea mays核酸以产生Zea mays标记扩增子。

5. 发明申请

US20100204921A1 METHOD FOR SELECTING STATISTICALLY VALIDATED CANDIDATE GENES 有权
标题翻译：选择统计证实候选基因的方法
公开(公告)号：US20100204921A1
公开(公告)日：2010-08-12
申请号：US12367045
申请日：2009-02-06
申请人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
发明人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06F19/24
摘要： Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
摘要翻译：本文提供了评估候选基因与群体中感兴趣的性状之间的关联的方法。这些方法包括全基因组关联分析和嵌套关联定位（NAM），表达QTL分析（eQTL）和等位基因分析（AEA）中的一个或多个的组合。如果使用GWA和NAM和eQTL中的一个或两个的组合显示与感兴趣的特征呈正相关的标记被选择或优先化。还提供了用于评估候选标记与嵌套生物群体中的性状之间的关联的模型。这些方法包括单标记回归和多标记回归模型。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，作为用于构建连锁图谱，用于基因发现，用于鉴定有助于感兴趣性状的基因以及产生具有所需性状的转基因生物的遗传标记。

6. 发明申请

US20110035847A1 YIELD TRAITS FOR MAIZE 有权
公开(公告)号：US20110035847A1
公开(公告)日：2011-02-10
申请号：US12536147
申请日：2009-08-05
申请人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
发明人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
IPC分类号： A01H5/00 , C12N15/82 , C12Q1/68 , C07H21/00 , C12N15/74
CPC分类号： A01H1/04 , A01H3/00 , A01H5/10 , C12N15/8261 , C12Q1/6895 , C12Q2600/13
摘要： Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.

7. 发明申请

US20100145624A1 STATISTICAL VALIDATION OF CANDIDATE GENES 审中-公开
标题翻译：候选基因的统计验证
公开(公告)号：US20100145624A1
公开(公告)日：2010-06-10
申请号：US12328689
申请日：2008-12-04
申请人： Venkata Krishna Kishore , Daolong Wang , Libardo Andres Gutierrez Rojas , Nicolas Federico Martin
发明人： Venkata Krishna Kishore , Daolong Wang , Libardo Andres Gutierrez Rojas , Nicolas Federico Martin
IPC分类号： G06F19/00
CPC分类号： G16B20/00 , G16B40/00
摘要： Provided herein are methods for evaluating associations between candidate markers and a trait of interest in a plant population. In various embodiments, the plant population is a breeding population, particularly early stage breeding populations. The methods include obtaining a genotypic value for candidate markers and correlating the marker with the trait. Various association models can be used to evaluate the association, and include statistical methods relevant to the structure of plant breeding populations. Population structure may be accounted for in the association models by using Principle Component Analysis. Further provided is a novel statistical approach for association mapping in early stage breeding materials using a transmission disequilibrium based methodology. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, for constructing genetic linkage maps, to identify genes contributing to a trait of interest, and for generating transgenic plants having a desired trait.
摘要翻译：本文提供了用于评估候选标记与植物群体中感兴趣的性状之间的关联的方法。在各种实施方案中，植物群体是育种群体，特别是早期育种群体。所述方法包括获得候选标记的基因型值并将标记与性状相关联。可以使用各种关联模型来评估关联，并且包括与植物育种种群结构相关的统计学方法。人口结构可以通过使用主成分分析在关联模型中加以考虑。进一步提供了一种用于使用基于传输不平衡的方法的早期育种材料中的关联定位的新颖的统计方法。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，用于构建遗传连锁图谱，鉴定有助于感兴趣性状的基因以及产生具有期望性状的转基因植物。

8. 发明授权

US08170805B2 Method for selecting statistically validated candidate genes 有权
标题翻译：选择统计学验证的候选基因的方法
公开(公告)号：US08170805B2
公开(公告)日：2012-05-01
申请号：US12367045
申请日：2009-02-06
申请人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
发明人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
IPC分类号： C12Q1/68 , G01N33/48 , G06G7/58
CPC分类号： G06F19/18 , G06F19/24
摘要： Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
摘要翻译：本文提供了评估候选基因与群体中感兴趣的性状之间的关联的方法。这些方法包括全基因组关联分析和嵌套关联定位（NAM），表达QTL分析（eQTL）和等位基因分析（AEA）中的一个或多个的组合。如果使用GWA和NAM和eQTL中的一个或两个的组合显示与感兴趣的特征呈正相关的标记被选择或优先化。还提供了用于评估候选标记与嵌套生物群体中的性状之间的关联的模型。这些方法包括单标记回归和多标记回归模型。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，作为用于构建连锁图谱，用于基因发现的遗传标记，用于鉴定有助于感兴趣的性状的基因以及产生具有所需性状的转基因生物。

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