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1. 发明授权

EP1140158B1 MULTI-COMPONENT VACCINE COMPRISING AT LEAST TWO ANTIGENS FROM HAEMOPHILUS INFLUENZAE 有权
标题翻译： MULTIKOMPONENTIMPFSTOFF与至少两个流感嗜血杆菌抗原
公开(公告)号：EP1140158B1
公开(公告)日：2006-09-13
申请号：EP99957822.2
申请日：1999-12-15
申请人： Sanofi Pasteur Limited , Loosmore, Sheena M. , Yang, Yan-Ping , Klein, Michel H.
发明人： LOOSMORE, Sheena, M. , YANG, Yan-Ping , KLEIN, Michel, H.
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

2. 发明公开

EP1140158A2 MULTI-COMPONENT VACCINE COMPRISING AT LEAST TWO ANTIGENS FROM HAEMOPHILUS INFLUENZAE 有权
标题翻译： MULTIKOMPONENTIMPFSTOFF与至少两个流感嗜血杆菌抗原
公开(公告)号：EP1140158A2
公开(公告)日：2001-10-10
申请号：EP99957822.2
申请日：1999-12-15
申请人： Aventis Pasteur Limited , Loosmore, Sheena M. , Yang, Yan-Ping , Klein, Michel H.
发明人： LOOSMORE, Sheena, M. , YANG, Yan-Ping , KLEIN, Michel, H.
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

3. 发明专利

AT339221T 未知
公开(公告)号：AT339221T
公开(公告)日：2006-10-15
申请号：AT99957822
申请日：1999-12-15
申请人： SANOFI PASTEUR LTD , LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

4. 发明专利

DE69933237D1 未知
公开(公告)号：DE69933237D1
公开(公告)日：2006-10-26
申请号：DE69933237
申请日：1999-12-15
申请人： SANOFI PASTEUR LTD , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE M , YANG YAN-PING , KLEIN H
IPC分类号： A61K39/102 , C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/116 , A61K39/13 , A61K39/295 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

5. 发明专利

AU1543900A Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease 未知
公开(公告)号：AU1543900A
公开(公告)日：2000-07-03
申请号：AU1543900
申请日：1999-12-15
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

6. 发明申请

WO0055191A3 RECOMBINANT HAEMOPHILUS INFLUENZAE ADHESIN PROTEINS 审中-公开
标题翻译：重组HAEMOPHILUS INFLUENZAE粘蛋白蛋白
公开(公告)号：WO0055191A3
公开(公告)日：2001-08-02
申请号：PCT/CA0000289
申请日：2000-03-16
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/00 , A61K39/145 , A61P11/00 , A61P27/16 , A61P31/04 , A61P31/16 , C07K14/195 , C07K14/285 , C12N1/21 , C12P21/02 , C12R1/19 , A61K38/00 , C12N15/00
CPC分类号： C07K14/285 , A61K39/00
摘要： Recombinant production of Hia protein, in full-length and N-terminally truncated forms, of non-typeable strains of Haemophilus influenzae, is described. The nucleic acid and deduced amino acid sequences of Hia genes of various strains of non-typeable and type c Haemophilus influenzae also are described.
摘要翻译：描述了全长和N-末端截短形式的流感嗜血杆菌不可逆型菌株的Hia蛋白的重组产生。还描述了不同型和流感嗜血杆菌流感嗜血杆菌的各种不同菌株的Hia基因的核酸和推断的氨基酸序列。

7. 发明申请

WO1996026282A1 EXPRESSION OF GENE PRODUCTS FROM GENETICALLY MANIPULATED STRAINS OF BORDETELLA 审中-公开
标题翻译：表达来自BORDETELLA的遗传操作菌株的基因产物
公开(公告)号：WO1996026282A1
公开(公告)日：1996-08-29
申请号：PCT/CA1996000107
申请日：1996-02-23
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena, M. , YACOOB, Reza, Khayyam , ZEALEY, Gavin, R. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/74
CPC分类号： C07K14/285 , C07K14/28 , C07K2319/02 , C12N15/74
摘要： An expression system for expressing gene products from recombinant Bordetella strains and specific nucleic acid molecules useful in transforming Bordetella strains for such expression are described. A nucleic acid molecule may comprise a Bordetella promoter operatively coupled to a heterologous gene encoding a non-Bordetella gene product with the heterologous gene transcriptionally regulated by the Bordetella promoter. The nucleic acid molecule may further comprise a further nucleic acid molecule encoding a leader sequence for secretion of the non-Bordetella gene product. Another nucleic acid molecule may comprise a Bordetella promoter coupled to a nucleic acid sequence encoding a non-Bordetella leader sequence for secretion of a gene product, which may be a Bordetella gene product or a non-Bordetella gene product.
摘要翻译：描述了用于表达来自重组博德特氏菌属菌株的基因产物和用于转化博德氏菌属菌株用于这种表达的特异性核酸分子的表达系统。核酸分子可以包含与编码非博德特氏菌基因产物的异源基因操作性偶联的博德特氏菌启动子与由博德特氏杆菌启动子转录调节的异源基因。核酸分子还可以包含编码用于分泌非博德特氏菌基因产物的前导序列的另外的核酸分子。另一种核酸分子可以包含与编码用于分泌基因产物的非博德特氏菌前导序列的核酸序列偶联的博德特氏菌启动子，其可以是博德特氏菌属基因产物或非博德特氏菌基因产物。

8. 发明申请

WO1996003506A2 ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY 审中-公开
标题翻译：具有减少蛋白酶活性的HAEMOPHILUS HIN47的模拟物
公开(公告)号：WO1996003506A2
公开(公告)日：1996-02-08
申请号：PCT/CA1995000434
申请日：1995-07-21
申请人： CONNAUGHT LABORATORIES LIMITED , LOOSMORE, Sheena, M. , YANG, Yan-Ping , CHONG, Pele , OOMEN, Raymond, P. , KLEIN, Michel, H.
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N9/52
摘要： The invention concerns isolated and purified analogs of Haemophilus influenza Hin47 protein with decreased protease activity (of less than 10 % of that of the natural protein) but preferably retaining substantially the same immunogenic properties as natural Hin47. Preferred analogs have mutations at Ser197, His91 and/or Asp121 positions and are possibly used as chimeric proteins with other immunogenic molecules. Also disclosed are nucleic acid encoding said analogs, recombinant plasmids and transformed host cells containing said modified genes, immunogenic compositions containing Hin47 analogs or their nucleic acid and their use for prophylactic, vaccine or diagnostic purposes.
摘要翻译：本发明涉及具有降低的蛋白酶活性（小于天然蛋白质的10％）的嗜血杆菌流感Hin47蛋白的分离和纯化的类似物，但优选保持与天然Hin47基本上相同的免疫原性。优选的类似物在Ser197，His91和/或Asp121位置具有突变，并且可能用作其它免疫原性分子的嵌合蛋白。还公开了编码所述类似物，重组质粒和含有所述修饰基因的转化宿主细胞的核酸，含有Hin47类似物或其核酸的免疫原性组合物及其用于预防，疫苗或诊断目的的用途。

9. 发明申请

WO0190383A3 CO-EXPRESSION OF RECOMBINANT PROTEINS 审中-公开
标题翻译：共表达重组蛋白
公开(公告)号：WO0190383A3
公开(公告)日：2002-08-08
申请号：PCT/CA0100611
申请日：2001-05-03
申请人： AVENTIS PASTEUR , LOOSMORE SHEENA M , YANG YAN-PING
发明人： LOOSMORE SHEENA M , YANG YAN-PING
IPC分类号： C07K14/285 , C12N15/63 , C12N15/70 , C07K14/315
CPC分类号： C07K14/285 , C07K2319/00 , C12N15/63 , C12N15/70
摘要： Expression vectors are described which permit the recombinant expression of proteins which essentially contain, in addition to nucleic acid encoding the recombinant protein, nucleic acid encoding a non-proteolytic analog of Haemophilus Hin47 protein, with or without leader sequence, or nucleic acid encoding high molecular weight proteins of non-typeable Haemophilus , which are hmwB , hmwC or hmwBC .
摘要翻译：描述了允许重组表达蛋白质的重组表达，除了编码重组蛋白的核酸之外，还包含编码嗜血杆菌Hin47蛋白的非蛋白水解类似物的核酸，具有或不具有前导序列，或编码高分子量的核酸不可分泌型嗜血杆菌的重量蛋白，其为hmwB，hmwC或hmwBC。

10. 发明申请

WO0105424A3 MULTI-COMPONENT VACCINE TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS 审中-公开
标题翻译：多元分子疫苗可以防止由海马流感引起的疾病和 MORAXELLA CATARRHALIS

公开(公告)号：WO0105424A3

公开(公告)日：2001-08-02

申请号：PCT/CA0000811

申请日：2000-07-11

申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H , SASAKI KEN

发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H , SASAKI KEN

IPC分类号： A61K39/116 , A61P31/04

CPC分类号： A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/70

摘要： A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis . Such composition comprises at least four antigens comprising at least one antigen from Haemophilus influenzae , and at least one antigen from Moraxella catarrhalis . Three of the antigens are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of Moraxella catarrhalis comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.

摘要翻译：多价免疫原性组合物赋予免疫宿主免受针对流感嗜血杆菌和卡他莫拉菌的<！ - SIPO - >引起的感染的保护。这样的组合物包含至少四种包含来自嗜血杆菌流感嗜血杆菌的至少一种抗原的抗原和至少一种来自卡他莫拉菌的抗原。三种抗原是粘附素。不可分泌的嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白和卡他莫拉菌的200kDa外膜蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。每个成分不影响其他成分的免疫原性。多价免疫原性组合物可以与DTP组分疫苗组合，其也可以包括非毒性脊髓灰质炎病毒和PRP-T，以提供组分疫苗，而不损害其他抗原的免疫原性。

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