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1. 发明申请

WO2009107971A3 POLYPEPTIDE SPECIFICALLY COUPLED TO PHOSPHATIDYLSERINE AND USE THEREOF 审中-公开
标题翻译：多肽特异性地与磷酸二酯结合并使用
公开(公告)号：WO2009107971A3
公开(公告)日：2009-11-26
申请号：PCT/KR2009000882
申请日：2009-02-25
申请人： KYUNGPOOK NAT UNIVERISTY INDUS , KIM IN SAN , LEE BYUNG HEON , NARENDRA THAPA
发明人： KIM IN SAN , LEE BYUNG HEON , NARENDRA THAPA
IPC分类号： C07K7/06
CPC分类号： G01N33/57492 , A61K47/64 , A61K49/0043 , C07K7/06 , G01N33/92 , G01N2405/04 , G01N2510/00
摘要： The present invention relates to a polypeptide which is specifically coupled to a phosphatidylserine and the use thereof, and more particularly: to a polypeptide which has an amino acid sequence represented by sequence number 1, and is specifically coupled to phosphatidylserine; to the phosphatidylserine detection use thereof; to a phosphatidylserine detection method using same; to the use thereof in dead cell detection; to the drug delivery use thereof; to the use thereof as a neoplastic disease treatment; to the neoplastic disease part imaging use thereof; and the like. The polypeptide of the present invention, having an amino acid sequence represented by sequence number 1, can be specifically coupled to a phosphatidylserine. Therefore, the polypeptide of the present invention is useful in detecting a phosphatidylserine, and further in detecting or imaging a dead cell which reveals phosphatidylserine on the surface of the cell, and a tumor cell.
摘要翻译：本发明涉及与磷脂酰丝氨酸特异性偶联的多肽及其用途，更具体地说，涉及具有序列号1所示的氨基酸序列并与磷脂酰丝氨酸特异性结合的多肽; 涉及磷脂酰丝氨酸检测用途; 涉及使用其的磷脂酰丝氨酸检测方法; 在死细胞检测中的用途; 其药物用途; 将其用作肿瘤疾病治疗; 涉及肿瘤疾病部位成像用途; 等等。具有序列号1所示的氨基酸序列的本发明的多肽可以与磷脂酰丝氨酸特异性结合。因此，本发明的多肽可用于检测磷脂酰丝氨酸，并且进一步检测或成像在细胞表面上显示磷脂酰丝氨酸的死细胞和肿瘤细胞。

2. 发明申请

WO2009148252A2 STROKE-TARGETING PEPTIDE AND USE THEREOF 审中-公开
标题翻译： STROKE-TARGETING PEPTIDE及其用途
公开(公告)号：WO2009148252A2
公开(公告)日：2009-12-10
申请号：PCT/KR2009002937
申请日：2009-06-02
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
发明人： LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a stroke-targeting peptide and use thereof. More specifically, the present invention relates to: a stroke-targeting peptide wherein it is represented by an amino acid sequence selected from the group consisting of sequence numbers 1 to 4; and use of the stroke-targeting peptide. The peptide provided by the present invention is characterized by binding specifically to stroke cells within a living body, and thus it can beneficially be used in stroke-diagnosing markers and kits, and drug-delivery compositions and pharmaceutical compositions targeting stroke, and stroke-imaging compositions.
摘要翻译：本发明涉及卒中靶向肽及其用途。更具体地，本发明涉及：中风靶向肽，其中由选自序列号1至4的氨基酸序列表示; 和使用中风靶向肽。本发明提供的肽的特征在于特异性结合生物体内的中风细胞，因此可有利地用于中风诊断标记物和试剂盒，以及药物递送组合物和靶向中风和中风成像的药物组合物成分。

3. 发明申请

WO2009139570A1 PEPTIDES FOR TARGETING APOPTOTIC CELLS AND USES THEREOF 审中-公开
标题翻译：用于靶向细胞的细胞及其用途
公开(公告)号：WO2009139570A1
公开(公告)日：2009-11-19
申请号：PCT/KR2009/002491
申请日：2009-05-12
申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , LEE, Byung Heon , KIM, In San
发明人： LEE, Byung Heon , KIM, In San
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0043 , A61K49/0056 , C07K2319/33 , G01N2510/00
摘要： The present invention relates to a peptide capable of specifically targeting apoptotic cells undergoing apoptosis and a use thereof. More particularly, it relates to a peptide having an amino acid sequence represented by anyone selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 12 and targeting apoptotic cells, a composition for detection of apoptotic cells comprising the same as an effective ingredient, a composition for drug delivery comprising the same as an effective ingredient, a composition for imaging comprising the same as an effective ingredient and the like. The peptide of the present invention effectively detects apoptosis which is involved in tissues of neoplastic disease, myocardial infarction, stroke and arteriosclerosis. Accordingly, the peptide of the present invention may be used in imaging of diagnosis of the said diseases and reaction against a drug by binding imaging reagent and etc. as well as in protection and treatment for the said diseases by binding a treatment reagent and then delivering drug selectively.
摘要翻译：本发明涉及能够特异性靶向经历凋亡的凋亡细胞的肽及其用途。更具体地说，本发明涉及一种具有由选自SEQ ID NO：1至SEQ ID NO：12的任何一个所代表的氨基酸序列并且靶向凋亡细胞的肽，用于检测凋亡细胞的组合物包含与SEQ ID NO：有效成分，用于药物递送的组合物，其包含与有效成分相同的组合物，用于成像的组合物，其包含其作为有效成分等。本发明的肽有效地检测参与肿瘤性疾病，心肌梗塞，中风和动脉硬化的组织的凋亡。因此，本发明的肽可以用于诊断所述疾病的成像和通过结合成像试剂等对药物的反应，以及通过结合治疗试剂来保护和治疗所述疾病，然后递送药物选择性。

4. 发明申请

WO2004087193A1 USE OF A PEPTIDE THAT INTERACTS WITH ALPHA V BETA3 INTEGRIN OF ENDOTHELIAL CELL 审中-公开
标题翻译：使用与ALPHA V BETA3内皮细胞相互作用的肽
公开(公告)号：WO2004087193A1
公开(公告)日：2004-10-14
申请号：PCT/KR2004/000774
申请日：2004-04-02
申请人： REGEN BIOTECH INC.. , NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
发明人： NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
IPC分类号： A61K38/16
CPC分类号： A61K38/10
摘要： The present invention relates to the novel use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (YH) or asparagine-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.
摘要翻译：本发明涉及与内皮细胞的alphavbeta3整联蛋白相互作用的肽的新用途。更具体地说，本发明涉及使用包含酪氨酸 - 组氨酸（YH）或天冬酰胺 - 组氨酸（NH）的至少18个氨基酸的肽来抑制内皮细胞粘附，内皮细胞迁移和/或血管发生的方法，以及至少三个具有庞大侧链的疏水性氨基酸; 或其等同物。此外，本发明提供了使用肽治疗或预防血管生成相关疾病的方法。

5. 发明申请

WO2012144799A3 PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES 审中-公开
标题翻译：蛋白质骨架模块增加了活性多聚体的结合亲和性和结合特异性
公开(公告)号：WO2012144799A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012002958
申请日：2012-04-18
申请人： KYUNGPOOK NAT UNIV IND ACAD , CHA KIWEON , SO IN-SEOP , KIM SOYOUN , LEE BYUNG-HEON , KIM IN SAN
发明人： CHA KIWEON , SO IN-SEOP , KIM SOYOUN , LEE BYUNG-HEON , KIM IN SAN
IPC分类号： C07K14/705 , C12N15/12 , G01N33/68
CPC分类号： C07K14/485 , C07K14/47 , C07K14/5406 , C07K14/705 , C07K2319/00 , G01N33/68
摘要： The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1st to 19th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29th to 86th amino acids of the amino acid sequence expressed in sequence number 1. The present invention also relates to a method for preparing the protein skeletal module. The protein skeletal module of the present invention increases the binding affinity or binding specificity of active polypeptides embedded therein, and therefore is effective in diagnosing and treating diseases.
摘要翻译：本发明涉及增加活性多肽的结合亲和力或结合特异性的新型蛋白质骨架模块。更具体地说，本发明涉及蛋白质骨架模块，其包含由序列1表示的氨基酸序列的第1至第19个氨基酸组成的多肽; 包含活性多肽的多肽; 和由序列号1表示的氨基酸序列的第29〜第86位氨基酸组成的多肽。本发明还涉及蛋白质骨架模块的制备方法。本发明的蛋白质骨架模块增加嵌入其中的活性多肽的结合亲和力或结合特异性，因此有效地诊断和治疗疾病。

6. 发明申请

WO2011081443A3 TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：用于诊断和治疗含有特异靶向白细胞介素-4受体的肽的含脂质体的脂质体的靶向药物递送系统及其制造方法
公开(公告)号：WO2011081443A3
公开(公告)日：2011-12-01
申请号：PCT/KR2010009495
申请日：2010-12-29
申请人： KYUNGPOOK NAT UNIV IND ACAD , IND TECH RES INST , KIM IN SAN , LEE BYUNG HEON , LU MAGGIE JM , LIANG HSIANG-FA , KO YI-JU , LO YA-CHIN , CHANG LI-WEN , WEI MING-CHEN
发明人： KIM IN SAN , LEE BYUNG HEON , LU MAGGIE JM , LIANG HSIANG-FA , KO YI-JU , LO YA-CHIN , CHANG LI-WEN , WEI MING-CHEN
IPC分类号： A61K9/127 , A61K38/20 , A61K47/18 , A61K47/30 , A61P35/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo (molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4RPep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
摘要翻译：用于诊断和治疗癌症的靶向药物递送系统及其制造方法技术领域本发明涉及一种用于诊断和治疗癌症的靶向药物递送系统及其制造方法，该系统包含特异性靶向白细胞介素-4受体的肽，含有根据本发明制备的IL4RPep肽标记的抗癌药物的脂质体可以将药物递送至其中IL-4受体通过与IL-4受体特异性结合的IL4RPep肽过表达的癌细胞，并且药物递送可以识别癌症细胞特别是由标签。因此，IL4RPep肽可以仅增加药物对癌症组织的作用，同时显着降低对正常组织的副作用，这使得体内（分子）成像和肿瘤的早期诊断成为可能。因此，含有本发明的IL4RPep肽标记的抗癌药物的脂质体可以作为靶向药物递送系统有效地用于癌症的诊断和治疗。

7. 发明申请

WO2011059262A3 USES OF APOPTOTIC CELL-TARGETING PEPTIDES, LABEL SUBSTANCES AND LIPOSOMES CONTAINING A THERAPEUTIC AGENT FOR PREVENTING, TREATING OR THERAPEUTICALLY DIAGNOSING APOPTOSIS-RELATED DISEASES 审中-公开
标题翻译：凋亡细胞靶向肽，标记物质和含有治疗剂的脂质体用于预防，治疗或治疗与细胞凋亡相关的疾病的用途
公开(公告)号：WO2011059262A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010007999
申请日：2010-11-12
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG-HEON , KIM IN SAN , OH YU KYOUNG
发明人： LEE BYUNG-HEON , KIM IN SAN , OH YU KYOUNG
IPC分类号： A61K9/127 , A61K38/08 , A61K49/00 , A61P35/00
CPC分类号： A61K49/0084 , A61K9/0019 , A61K9/127 , A61K31/704 , A61K31/7048 , A61K47/6911 , A61K49/0032 , A61K49/0056
摘要： The invention relates to compositions for preventing, treating or therapeutically diagnosing apoptosis-related diseases which comprises: apoptotic cell-targeting peptides, label substances and liposomes containing a therapeutic agent as an active ingredient. The compositions of the present invention can be used for a variety of purposes such as delivery of target drugs to apoptotic cells in cancer or tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in cerebral apoplexy tissue and apoptotic cells in arteriosclerotic tissue, and further, detection and imaging diagnosis of these cells, therefore they can be used not only for preventing or treating said diseases but also for therapeutically diagnostic purposes.
摘要翻译：本发明涉及用于预防，治疗或治疗性诊断细胞凋亡相关疾病的组合物，其包含：凋亡细胞靶向肽，标记物质和含有治疗剂作为活性成分的脂质体。本发明的组合物可以用于多种目的，例如将靶药物递送至癌症或肿瘤组织中的凋亡细胞，心肌梗塞组织中的凋亡心肌细胞，脑卒中组织中的凋亡神经细胞和动脉硬化组织中的凋亡细胞并进一步对这些细胞进行检测和成像诊断，因此它们不仅可用于预防或治疗所述疾病，而且还用于治疗诊断目的。

8. 发明申请

WO2011059263A3 PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF 审中-公开
标题翻译：通过血脑屏障通过的肽和靶向神经损伤性脑病的病原体及其用途
公开(公告)号：WO2011059263A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008000
申请日：2010-11-12
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG-HEON , KIM IN SAN , BAE JAE SUNG , JIN HEE KYOUNG , HAN HYUNG SOO
发明人： LEE BYUNG-HEON , KIM IN SAN , BAE JAE SUNG , JIN HEE KYOUNG , HAN HYUNG SOO
IPC分类号： A61K38/08 , A61K49/00 , A61P25/16 , A61P25/28
CPC分类号： A61K49/0002 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0056 , B82Y5/00 , C07K7/06
摘要： The invention relates to a peptide which passes through a blood-brain barrier and targets apoptosis of degenerative brain disease sites and uses thereof, and more specifically, to a composition for delivering drugs to brain tissues comprising a peptide having an amino acid sequence as represented in SEQ ID NO:1 as an active ingredient, a composition for detecting apoptotic cells of neurodegenerative brain disease sites, and a composition for imaging the sites of neurodegenerative brain disease and said peptide and a composition combined therewith for preventing, treating or therapeutically diagnosing neurodegenerative brain diseases. The peptide having the amino acid sequence as represented by SEQ ID NO:1 of the present invention can pass through the blood-brain barrier and specifically bind to apoptotic cells in tissues of neurodegenerative brain diseases. Therefore the peptide of the present invention can be used for a variety of purposes such as detection of apoptosis in neurodegenerative brain diseases, and further, detection and imaging diagnosis of apoptotic cells (particularly, apoptotic nerve cells) in tissues of neurodegenerative brain diseases, delivery of target drugs, diagnosis for treatment, and the like.
摘要翻译：本发明涉及通过血脑屏障并靶向退行性脑部疾病部位的凋亡及其用途的肽，更具体地，涉及用于将药物递送至脑组织的组合物，所述组合物包含具有下述氨基酸序列的肽： SEQ ID NO：1作为活性成分，用于检测神经变性脑病变部位的凋亡细胞的组合物，以及用于成像神经变性性脑病的位点和所述肽及其组合物的组合物，用于预防，治疗或诊断神经变性脑疾病。具有本发明的SEQ ID NO：1所示的氨基酸序列的肽可以通过血脑屏障，并特异性结合神经退行性脑病的组织中的凋亡细胞。因此，本发明的肽可以用于各种目的，例如检测神经变性脑疾病中的细胞凋亡，以及进一步检测和成像诊断神经变性脑疾病，递送的组织中的凋亡细胞（特别是凋亡神经细胞）目标药物，治疗诊断等。

9. 发明申请

WO2005099743A1 NOVEL USE OF A POLYPEPTIDE COMPRISING FAS-1 DOMAIN 审中-公开
标题翻译：包含FAS-1域的多肽的新用途
公开(公告)号：WO2005099743A1
公开(公告)日：2005-10-27
申请号：PCT/KR2004/000851
申请日：2004-04-13
申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
发明人： NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
IPC分类号： A61K38/16
CPC分类号： A61K38/16
摘要： The present invention relates to the novel use of a polypeptide comprising a fas-1 domain. More particularly, the invention relates to a method for the inhibition of the adhesion, migration and/or proliferation of endothelial cells, and/or for the inhibition of angiogenesis, using the polypeptide comprising the fas-1 domain, or functional equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the polypeptide.
摘要翻译：本发明涉及包含fas-1结构域的多肽的新用途。更具体地，本发明涉及使用包含fas-1结构域的多肽或其功能等同物来抑制内皮细胞的粘附，迁移和/或增殖和/或抑制血管生成的方法。此外，本发明提供了使用该多肽治疗或预防血管生成相关疾病的方法。

10. 发明申请

WO2009148252A3 STROKE-TARGETING PEPTIDE AND USE THEREOF 审中-公开
标题翻译： STROKE-TARGETING PEPTIDE及其用途
公开(公告)号：WO2009148252A3
公开(公告)日：2010-05-27
申请号：PCT/KR2009002937
申请日：2009-06-02
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
发明人： LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a stroke-targeting peptide and use thereof. More specifically, the present invention relates to: a stroke-targeting peptide wherein it is represented by an amino acid sequence selected from the group consisting of sequence numbers 1 to 4; and use of the stroke-targeting peptide. The peptide provided by the present invention is characterized by binding specifically to stroke cells within a living body, and thus it can beneficially be used in stroke-diagnosing markers and kits, and drug-delivery compositions and pharmaceutical compositions targeting stroke, and stroke-imaging compositions.
摘要翻译：本发明涉及卒中靶向肽及其用途。更具体地，本发明涉及：中风靶向肽，其中由选自序列号1至4的氨基酸序列表示; 和使用中风靶向肽。本发明提供的肽的特征在于特异性结合生物体内的中风细胞，因此可有利地用于中风诊断标记物和试剂盒，以及药物递送组合物和靶向中风和中风成像的药物组合物成分。

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