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1. 发明申请

US20090142375A1 LIPOTEICHOIC ACID FROM LACTIC ACID BACTERIA AND ITS USE TO MODULATE IMMUNE RESPONSES MADIATED BY GRAM-NEGATIVE BACTERIA, POTENTIAL PATHOGENIC GRAM-POSITIVE BACTERIA 失效
标题翻译：来自酸乳杆菌的LIPOTEICHOIC酸及其用于调节由GRAM阴性细菌引起的免疫应答，潜在致病性细菌性细菌
公开(公告)号：US20090142375A1
公开(公告)日：2009-06-04
申请号：US12246991
申请日：2008-10-07
申请人： Karine Vidal , Anne Donnet-Hughes , Dominique-Anne Granato , Irene Corthesy-Theulaz
发明人： Karine Vidal , Anne Donnet-Hughes , Dominique-Anne Granato , Irene Corthesy-Theulaz
IPC分类号： A61K39/02 , A61P37/02
CPC分类号： A61K31/70 , A23L33/135 , A23V2002/00 , A61K8/72 , A61K8/99 , A61K9/0095 , A61K31/739 , A61Q11/00 , A61Q19/00 , C12P19/44 , A23V2250/206
摘要： The invention relates to a composition for modulating the immune responses induced by Gram negative bacteria, potential pathogenic Gram positive bacteria and/or their derivatives, comprising lipoteichoic acid from lactic acid bacteria as an active ingredient. It also relates to the use of a lipoteichoic acid from lactic acid bacteria as an active ingredient and/or lactic acid bacteria producing it and/or its supernatant of culture, in the manufacture of a medicament, an oral or topical product for cosmetic, dermatological or ophtalmological applications, a food or petfood composition for modulating bacterial colonisation, immune responses and decreasing the inflammatory processes associated with bacterially-mediated disease and infection in the gastrointestinal tract, bone, skin, eye, ear, lung and oral cavity. The invention also relates to lipoteichoic acid selected thereof.
摘要翻译：本发明涉及一种用于调节由革兰氏阴性细菌诱导的免疫应答的组合物，其包含来自乳酸菌的脂磷壁酸作为活性成分的潜在致病革兰氏阳性菌和/或其衍生物。它还涉及在制备用于化妆品，皮肤病学的药物，口服或局部产品中使用来自乳酸菌的脂磷壁酸作为活性成分和/或产生其的乳酸菌和/或其培养上清液或眼科应用，用于调节细菌定植，免疫应答和减少与细菌介导的疾病和胃肠道，骨骼，皮肤，眼睛，耳朵，肺和口腔中的感染相关的炎症过程的食物或宠物食品组合物。本发明还涉及其选择的脂磷壁酸。

2. 发明申请

US20070104700A1 Nutritional formula for optimal gut barrier function 有权
标题翻译：最佳肠道屏障功能的营养配方
公开(公告)号：US20070104700A1
公开(公告)日：2007-05-10
申请号：US10562243
申请日：2004-06-22
申请人： Clara Garcia-Rodenas , Gabriela Bergonzelli , Florence Rochat , Marco Enrico Turini , Irene Corthesy-Theulaz , Christine Cherbut
发明人： Clara Garcia-Rodenas , Gabriela Bergonzelli , Florence Rochat , Marco Enrico Turini , Irene Corthesy-Theulaz , Christine Cherbut
IPC分类号： A61K35/74 , A61K31/22 , A61K31/715
CPC分类号： A61K31/736 , A23L33/12 , A23L33/135 , A23L33/19 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2220/63 , A23Y2300/55 , A61K31/202 , A61K31/702 , A61K31/733 , A23V2250/71 , A23V2250/712 , A23V2250/708 , A23V2250/714 , A23V2250/704 , A23V2250/54246 , A23V2250/5114 , A23V2250/60 , A23V2250/18 , A23V2250/1638 , A23V2250/70 , A23V2250/0616 , A23V2250/5488 , A23V2250/1614 , A23V2250/16 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/1868 , A23V2250/5062 , A23V2250/156 , A23V2250/0612 , A23V2250/641 , A23V2250/628 , A23V2250/612 , A61K2300/00
摘要： The present invention pertains to a composition for inducing a pattern of gut barrier maturation similar to that observed with breast-feeding and able to improve gut barrier maturation, e.g. during neonatal stress. In particular, the present invention relates to an infant formula containing a combination of specific ingredients designed to provide a synergistic effect all along gastrointestinal tract and barrier function.
摘要翻译：本发明涉及用于诱导肠道屏障成熟模式的组合物，其类似于用母乳喂养观察到的并且能够改善肠道屏障成熟，例如，在新生儿压力。特别地，本发明涉及含有特定成分的组合的婴儿配方，所述特定成分被设计成提供沿着胃肠道和屏障功能的协同作用。

3. 发明申请

US20060292171A1 Moderating the effect of endotoxins 审中-公开
标题翻译：调节内毒素的作用
公开(公告)号：US20060292171A1
公开(公告)日：2006-12-28
申请号：US10595396
申请日：2004-10-13
申请人： Irene Corthesy-Theulaz , Grigorios Fotopoulos , Gabriela Bergonzelli
发明人： Irene Corthesy-Theulaz , Grigorios Fotopoulos , Gabriela Bergonzelli
IPC分类号： A61K36/06
CPC分类号： A61K36/06 , Y02A50/409 , Y02A50/471 , Y02A50/473 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to the use of an oral composition comprising yeast extract, in the manufacture of an oral composition to treat the effects of infection by pathogenic bacteria such as Clostridium difficile. Such effects may include the failure of the integrity of the gut epithelial cells and diarrhoea as well as other COX-2 mediated effects.
摘要翻译：本发明涉及包含酵母提取物的口腔组合物在制造口腔组合物中以治疗致病细菌如艰难梭菌感染的作用的用途。这种作用可能包括肠上皮细胞和腹泻的完整性以及其他COX-2介导的作用的失败。

4. 发明申请

US20050181072A1 Use of essential oils for combating gi tract infection by helicobacter-like organisms 审中-公开
标题翻译：使用精油来防治幽门螺杆菌样生物体内的gi感染
公开(公告)号：US20050181072A1
公开(公告)日：2005-08-18
申请号：US10343546
申请日：2001-07-12
申请人： Irene Corthesy-Theulaz , Gabriela Bergonzelli , Antoine Audrin , Jean-Paul Marion , Robert Aeschbach
发明人： Irene Corthesy-Theulaz , Gabriela Bergonzelli , Antoine Audrin , Jean-Paul Marion , Robert Aeschbach
IPC分类号： A23F3/16 , A23G3/00 , A23G3/48 , A23L1/222 , A23L1/30 , A23L1/39 , A23L2/38 , A61K31/015 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/075 , A61K31/11 , A61K31/22 , A61K36/23 , A61K36/53 , A61K36/75 , A61K36/899 , A61K45/06 , A61P1/00 , A61P31/04 , C11B9/00 , C11B9/02 , A61K35/78
CPC分类号： A23G3/48 , A23F3/163 , A23L2/38 , A23L23/00 , A23L27/12 , A23L33/105 , A61K45/06 , C11B9/027
摘要： A nutritional composition comprising a specific essential oil and/or specific pure compound isolated from the essential oil for prevention or treatment of infection by an Helicobacter-like organism, a method of production of the composition, use of the composition in the manufacture of a functional food or medicament for the prevention or treatment of infection by an Helicobacter-like organism and a method of treatment of infection by an Helicobacter-like organism which comprises consumption or administration of a functional food or medicament comprising an effective amount of the composition.
摘要翻译：一种营养组合物，其包含从所述精油中分离的预防或治疗幽门螺杆菌样生物感染的特定精油和/或特定纯化合物，所述组合物的制备方法，所述组合物在制备功能性用于预防或治疗幽门螺杆菌样生物感染的食物或药物以及治疗幽门螺杆菌样生物感染的方法，其包括消耗或施用包含有效量的组合物的功能性食品或药物。

5. 发明申请

US20070122453A1 Moderating the effect of endotoxins 有权
标题翻译：调节内毒素的作用
公开(公告)号：US20070122453A1
公开(公告)日：2007-05-31
申请号：US10595397
申请日：2004-10-12
申请人： Irene Corthesy-Theulaz , Grigorios Fotopoulos , Gabriela Bergonzelli
发明人： Irene Corthesy-Theulaz , Grigorios Fotopoulos , Gabriela Bergonzelli
IPC分类号： A61K47/00 , A61K35/34 , A61K36/06
CPC分类号： A61K35/12 , A61K36/064 , A61K38/018 , Y02A50/409 , Y02A50/471 , Y02A50/473 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： The present invention relates to the use of an oral composition comprising meat extract and peptones, separately or in combination, in the manufacture of an oral composition to treat the effects of infection by pathogenic bacteria such as Clostridium difficile. Such effects may include the failure of the integrity of the gut epithelial cells and diarrhoea as well as other COX-2 mediated effects.
摘要翻译：本发明涉及包含肉提取物和胨的口腔组合物在口腔组合物的制造中的单独使用或组合用于治疗致病菌如艰难梭菌感染的作用的用途。这种作用可能包括肠上皮细胞和腹泻的完整性以及其他COX-2介导的作用的失败。

6. 发明授权

US5972336A Urease-based vaccine against helicobacter infection 失效
标题翻译：基于脲酶的针对幽门螺杆菌感染的疫苗
公开(公告)号：US5972336A
公开(公告)日：1999-10-26
申请号：US85938
申请日：1993-07-06
申请人： Pierre Michetti , Andre Blum , Catherine Davin , Rainer Haas , Irene Corthesy-Theulaz , Jean-Pierre Kraehenbuhl , Emilia Saraga
发明人： Pierre Michetti , Andre Blum , Catherine Davin , Rainer Haas , Irene Corthesy-Theulaz , Jean-Pierre Kraehenbuhl , Emilia Saraga
IPC分类号： G01N33/569 , A61K38/46 , A61K39/00 , A61K39/02 , A61K39/106 , A61K39/108 , A61K39/39 , A61K39/395 , A61P31/04 , A61P37/00 , C07K14/195 , C07K14/37 , C07K14/41 , C07K16/00 , C07K16/40 , C07K19/00 , C12N9/80 , C12N15/09 , C12N15/55 , C12R1/645 , G01N33/573 , A61K9/127 , A61K31/535 , A61K38/00
CPC分类号： C12N9/80 , A61K2039/541 , A61K2039/55505 , A61K2039/6037 , A61K39/00
摘要： Method of eliciting in a mammalian host a protective immune response to Helicobacter infection by administering to the host an immunogenically effective amount of a Helicobacter urease or urease subunits as antigen. Vaccine compositions are also provided.
摘要翻译：通过向宿主施用免疫原性有效量的作为抗原的尿素酶或脲酶亚基，在哺乳动物宿主中引发对幽门螺杆菌感染的保护性免疫应答的方法。还提供了疫苗组合物。

7. 发明申请

US20120270786A1 INTESTINE AND MUSCLE RECOVERY 审中-公开
标题翻译： INTESTINE和MUSCLE RECOVERY
公开(公告)号：US20120270786A1
公开(公告)日：2012-10-25
申请号：US13500784
申请日：2010-10-07
申请人： Didier Attaix , Audrey Codran-Raison , Irene Corthesy-Theulaz , Denis Breuille , Lydie Combaret
发明人： Didier Attaix , Audrey Codran-Raison , Irene Corthesy-Theulaz , Denis Breuille , Lydie Combaret
IPC分类号： A61K38/26 , A61P21/00
CPC分类号： A61K38/26 , A23L33/18 , A23V2002/00 , A61K2300/00 , A23V2200/316
摘要： The present invention generally relates to the field of nutrition and health. In particular, the present invention provides a composition that allows it to treat, limit or prevent muscle atrophy. Embodiments of the present invention are directed at GLP-2 containing compositions and to compositions that stimulate the secretion of GLP-2 in a body to treat or prevent muscle atrophy.
摘要翻译：本发明一般涉及营养与健康领域。特别地，本发明提供允许其治疗，限制或预防肌肉萎缩的组合物。本发明的实施方案涉及含GLP-2的组合物和刺激体内GLP-2分泌以治疗或预防肌肉萎缩的组合物。

8. 发明申请

US20070036836A1 Amino acid supplementation for a healthy microbiota ecosystem 审中-公开
标题翻译：健康微生物群落生态系统的氨基酸补充
公开(公告)号：US20070036836A1
公开(公告)日：2007-02-15
申请号：US10564807
申请日：2004-06-16
申请人： Magali Faure , Florence Rochat , Denis Breuille , Irene Corthesy-Theulaz
发明人： Magali Faure , Florence Rochat , Denis Breuille , Irene Corthesy-Theulaz
IPC分类号： A61K47/00
CPC分类号： A61K31/198 , A23K20/142 , A23K20/147 , A23K50/40 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K31/195 , A61K31/401 , A23V2250/0642 , A23V2250/064 , A23V2250/0648 , A23V2250/0616 , A23V2250/0612 , A23V2250/16 , A23V2250/1578 , A23V2250/161 , A23V2250/1612 , A23V2250/1592 , A23V2250/1588 , A23V2250/1642 , A23V2250/06 , A23V2250/156 , A23V2250/702 , A23V2250/704 , A23V2250/641 , A23V2250/0644
摘要： The present invention pertains to a nutritional composition for reconstituting an optimal healthy microbiota ecosystem in humans or animals. In particular, the present invention relates to an ingestible carrier containing specific amino acids designed to favor the growth of bacteria favorable to individuals health or for reducing the risk of developing deleterious events. The invention also pertains to the use of specific amino acids for reconstituting an optimal healthy microbiota ecosystem in humans or animals, in particular in infants, critically ill patients, in the case of chronic diseases or any stresses impacting the gut and in elderly people.
摘要翻译：本发明涉及用于重建人或动物中最佳健康微生物群落生态系统的营养组合物。特别地，本发明涉及含有特定氨基酸的可摄入载体，其被设计为有利于有利于个人健康的细菌的生长或用于降低发生有害事件的风险。本发明还涉及特定氨基酸用于在人或动物，特别是婴儿，危重病患者，慢性疾病或任何影响肠道和老年人的压力的情况下，重建最佳的健康微生物群落生态系统。

9. 发明授权

US6060241A Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases 失效
标题翻译：与药物发现和检测和治疗胃肠道疾病有关的组成和方法
公开(公告)号：US6060241A
公开(公告)日：2000-05-09
申请号：US834776
申请日：1997-04-03
申请人： Irene Corthesy-Theulaz
发明人： Irene Corthesy-Theulaz
IPC分类号： A61K38/00 , C12N9/00 , C12N9/10 , C12N15/54 , C12Q1/68 , C12Q1/70
CPC分类号： C12N9/1029 , C12N9/00 , C12N9/10 , C12Q1/689 , A61K38/00 , C12Q2600/136
摘要： A poly-3-hydroxybutyrate metabolic pathway essential for Helicobacter pylori survival in a host is provided. A novel Helicobacter pylori Coenzyme A transferase (Hp CoA-t), thiolase and PHB synthase as well as methods for their preparation and use are provided. Hp CoA-t and thiolase polynucleotides and proteins are provided as well as detection and preparative methods using such molecules. Methods for the determination of a propensity to develop gastritis, peptic ulcer disease, or gastric cancer is provided for by detection methods. Methods are also provided for the use of Hp CoA-t, thiolase or PHB synthase proteins and fragments retaining enzymatic activity in the identification of potential drug candidates for the treatment of some types of gastric disease. Pharmaceutical compositions containing Hp CoA-t protein fragments, antisense nucleic acids or other inhibitors of Hp CoA-t, thiolase and PHB synthase as well as methods for their use in the treatment of some types of gastric disease are also provided.
摘要翻译：提供了在宿主中幽门螺杆菌存活所必需的聚-3-羟基丁酸酯代谢途径。提供了一种新型幽门螺杆菌辅酶A转移酶（Hp CoA-t），硫解酶和PHB合酶以及其制备和使用方法。提供Hp CoA-t和硫解酶多核苷酸和蛋白质以及使用这种分子的检测和制备方法。通过检测方法提供测定胃炎，消化性溃疡病或胃癌倾向的方法。还提供了使用Hp CoA-t，硫解酶或PHB合酶蛋白的方法以及保留酶活性的片段，用于鉴定潜在的候选药物用于治疗某些类型的胃病。还提供了含有Hp CoA-t蛋白片段，反义核酸或其他Hp CoA-t，硫解酶和PHB合成酶抑制剂的药物组合物，以及其用于治疗某些类型胃病的方法。

10. 发明授权

US08329190B2 Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria 失效
标题翻译：来自乳酸菌的脂磷壁酸及其用于调节由革兰氏阴性细菌介导的免疫应答，潜在致病性革兰氏阳性菌
公开(公告)号：US08329190B2
公开(公告)日：2012-12-11
申请号：US12246991
申请日：2008-10-07
申请人： Karine Vidal , Anne Donnet-Hughes , Dominique-Anne Granato , Irene Corthesy-Theulaz
发明人： Karine Vidal , Anne Donnet-Hughes , Dominique-Anne Granato , Irene Corthesy-Theulaz
IPC分类号： A61K39/00 , A61K39/385 , A61K45/00 , A61K47/00
CPC分类号： A61K31/70 , A23L33/135 , A23V2002/00 , A61K8/72 , A61K8/99 , A61K9/0095 , A61K31/739 , A61Q11/00 , A61Q19/00 , C12P19/44 , A23V2250/206
摘要： The invention relates to a composition for modulating the immune responses induced by Gram negative bacteria, potential pathogenic Gram positive bacteria and/or their derivatives, comprising lipoteichoic acid from lactic acid bacteria as an active ingredient. It also relates to the use of a lipoteichoic acid from lactic acid bacteria as an active ingredient and/or lactic acid bacteria producing it and/or its supernatant of culture, in the manufacture of a medicament, an oral or topical product for cosmetic, dermatological or ophtalmological applications, a food or petfood composition for modulating bacterial colonization, immune responses and decreasing the inflammatory processes associated with bacterially-mediated disease and infection in the gastrointestinal tract, bone, skin, eye, ear, lung and oral cavity. The invention also relates to lipoteichoic acid selected thereof.
摘要翻译：本发明涉及一种用于调节由革兰氏阴性细菌诱导的免疫应答的组合物，其包含来自乳酸菌的脂磷壁酸作为活性成分的潜在致病革兰氏阳性菌和/或其衍生物。它还涉及在制备用于化妆品，皮肤病学的药物，口服或局部产品中使用来自乳酸菌的脂磷壁酸作为活性成分和/或产生其的乳酸菌和/或其培养上清液或眼科应用，用于调节细菌定植，免疫应答和减少与细菌介导的疾病和胃肠道，骨骼，皮肤，眼睛，耳朵，肺和口腔中的感染相关的炎症过程的食物或宠物食品组合物。本发明还涉及其选择的脂磷壁酸。

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