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1. 发明申请

US20080176288A1 Recombinant Production of Polyanionic Polymers, and Uses Thereof 审中-公开
标题翻译：聚阴离子聚合物的重组生产及其用途
公开(公告)号：US20080176288A1
公开(公告)日：2008-07-24
申请号：US11928737
申请日：2007-10-30
申请人： David W. Leung , Philip A. Bergman , Alan Lofquist , Gregory E. Pietz , Christopher K. Tompkins , David W. Waggoner
发明人： David W. Leung , Philip A. Bergman , Alan Lofquist , Gregory E. Pietz , Christopher K. Tompkins , David W. Waggoner
IPC分类号： C12P21/00 , C07K1/00 , C07K16/00 , C12N15/64
CPC分类号： C07K7/06 , A61K47/645 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
摘要翻译：聚阴离子聚合物可以改善与其结合的药物的生物活性和水溶性。本发明的方法提供可以容易地操作的重组生产的聚阴离子聚合物的单分散制剂，例如延长的。活性部分可以化学或重组连接到聚阴离子聚合物以增加其生物半衰期和/或溶解度。本发明还提供了将聚阴离子聚合物缀合物或融合蛋白递送至特定细胞类型或组织的方法。

2. 发明授权

US07199238B2 LPAAT-β inhibitors and uses thereof 失效
公开(公告)号：US07199238B2
公开(公告)日：2007-04-03
申请号：US11224340
申请日：2005-09-12
申请人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J. Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
发明人： Lynn Bonham , Baoqing Gong , Robert E Finney , David M Hollenback , J. Peter Klein , David W Leung , Scott A Shaffer , Norina M Tang , John Tulinsky , Thayer H White
IPC分类号： C07D251/52 , C07D251/38 , A61K31/53 , A61P35/00
CPC分类号： C07D251/70 , C07D251/50 , C07D251/52 , C07D251/54 , C07D251/58
摘要： The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.

3. 发明授权

US5688763A Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein 失效
标题翻译：用于合成生长激素受体和生长激素结合蛋白的组合物和方法
公开(公告)号：US5688763A
公开(公告)日：1997-11-18
申请号：US248832
申请日：1994-05-25
申请人： R. Glenn Hammonds, Jr. , David W. Leung , Steven A. Spencer , William I. Wood , Peter Cameron Colosi
发明人： R. Glenn Hammonds, Jr. , David W. Leung , Steven A. Spencer , William I. Wood , Peter Cameron Colosi
IPC分类号： A61K38/00 , C07K14/71 , G01N33/74 , A61K38/27 , A61K38/17 , A61K38/18 , C07K14/72
CPC分类号： C07K14/71 , G01N33/74 , A61K38/00
摘要： Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expression systems for recombinant production of growth hormone receptor and growth hormone binding protein. Therapeutically useful forms of the growth hormone receptor and growth hormone binding protein and anti-receptor antibodies are described.
摘要翻译：纯化生长激素受体和生长激素结合蛋白，使氨基酸序列和编码生长激素受体和生长激素结合蛋白的DNA分离物和获得此类DNA的方法与生物激素受体和生长激素重组生产的表达系统一起提供结合蛋白。描述了生长激素受体和生长激素结合蛋白和抗受体抗体的治疗上有用的形式。

4. 发明授权

US07052891B2 Human lysophoshatidic acid acyltransferase gamma-1 polypeptide 失效
标题翻译：人溶血糖酸酰基转移酶γ-1多肽
公开(公告)号：US07052891B2
公开(公告)日：2006-05-30
申请号：US10667494
申请日：2003-09-23
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： G12N9/10
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

5. 发明授权

US07045327B2 Human lysophosphatidic acid acyltransferase gamma-2 polypeptide 失效
标题翻译：人溶血磷脂酸酰基转移酶γ-2多肽
公开(公告)号：US07045327B2
公开(公告)日：2006-05-16
申请号：US10667462
申请日：2003-09-23
申请人： David W. Leung , Daniel Adourel , David Hollenback
发明人： David W. Leung , Daniel Adourel , David Hollenback
IPC分类号： C12N9/10
CPC分类号： C12N9/1029
摘要： Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：多肽例如通过编码cDNA序列的表达获得，其具有酶溶血磷脂酸酰基转移酶（LPAAT）的活性，也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

6. 发明授权

US5985926A Method for inhibiting intracellular viral replication 失效
标题翻译：抑制细胞内病毒复制的方法
公开(公告)号：US5985926A
公开(公告)日：1999-11-16
申请号：US797326
申请日：1997-02-10
申请人： David W. Leung , Gail E. Underiner , Jack W. Singer
发明人： David W. Leung , Gail E. Underiner , Jack W. Singer
IPC分类号： A61K31/4035 , A61K31/445 , A61K31/472 , A61K31/513 , A61K31/522 , C12N15/48 , A61K31/20
CPC分类号： A61K31/522 , A61K31/4035 , A61K31/445 , A61K31/472 , A61K31/513
摘要： There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an effective amount of a compound that inhibits cellular signaling through a specific phospholipid-based cellular signaling and signal amplification pathway. The invention further provides a method for preventing or delaying clinical symptoms of a group of viral diseases wherein the viral disease is mediated by host cell viral replication. The invention provides an advantage by attacking host cellular signaling mechanisms to prevent the development of drug resistance from rapidly mutating viruses.
摘要翻译：公开了通过施用有效量的抑制细胞信号传导的化合物通过特定的基于磷脂的细胞信号传导和信号扩增来预防或延迟人类免疫缺陷病毒（HIV）血清阳性人类中的获得性免疫缺陷综合征（AIDS）的发生的方法途径。本发明还提供了一种用于预防或延缓一组病毒性疾病的临床症状的方法，其中所述病毒性疾病由宿主细胞病毒复制介导。本发明通过攻击宿主细胞信号传导机制来提供一个优点，以防止快速突变病毒对耐药性的发展。

7. 发明授权

US5807861A Amine substituted xanthinyl compounds 失效
标题翻译：胺取代的黄原胶化合物
公开(公告)号：US5807861A
公开(公告)日：1998-09-15
申请号：US476911
申请日：1995-06-07
申请人： J. Peter Klein , Gail E. Underiner , Anil M. Kumar , Lance H. Ridgers , Glenn C. Rice , David W. Leung
发明人： J. Peter Klein , Gail E. Underiner , Anil M. Kumar , Lance H. Ridgers , Glenn C. Rice , David W. Leung
IPC分类号： C07D239/54 , C07D473/04 , C07D473/06 , C07D487/04 , C07D513/04 , A61K31/52
CPC分类号： C07D239/54 , C07D473/04 , C07D473/06 , C07D487/04 , C07D513/04
摘要： A method for treating a disease caused by an undesirable cell response mediated by a proliferative intracellular signaling pathway is provided wherein an effective amount of a compound is administered. The compound, resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof, has the formula CORE MOIETY--(R).sub.j wherein j is an integer from one to three; the core moiety is xanthinyl; and R is independently selected from the group consisting of amine, hydrogen, halogen, hydroxyl, C.sub.(1-10) alkyl, C.sub.(2-10) alkenyl, 2-bromopropyl, 4-chloropentyl, cyclohexyl, cyclopentyl, 3-dimethylaminobutyl, 2-hydroxyethyl, 5-hydroxyhexyl, 3-hydroxy-n-butyl, 3-hydroxypropyl, 2-methoxyethyl, 4-methoxy-n-butyl, phenyl, and formula I, at least one R comprising formula I ##STR1## wherein (CH.sub.2).sub.n is optionally substituted; n is an integer from five to twenty; each R.sub.1 or R.sub.2 is independently hydrogen or an optionally substituted group that is herein defined; and wherein, when the (CH.sub.2).sub.n, R.sub.1 or R.sub.2 is substituted, a substituent is selected from the group consisting of carbamoyl, primary, secondary and tertiary amino, C.sub.(2-8) alkenyl, C.sub.(1-8) alkyl, C.sub.(1-8) alkoxyl, C.sub.(1-8) hydroxyalkyl, azido, carbonato, carbonyl, carboxyl, cyano, C.sub.(1-8) haloalkyl, isocyano, isomercaptocyano, phospho, phosphonato, sulfonato, alkylsulfonyl, alkylsulfoxidyl, mercaptocarbonyl, mercaptocarbonato, thioureido and ureido.
摘要翻译：提供了治疗由增殖性细胞内信号传导途径介导的不良细胞应答引起的疾病的方法，其中施用有效量的化合物。化合物，拆分的对映体，非对映异构体，水合物，盐，溶剂合物及其混合物具有式CORE MOIETY-（R）j，其中j是1至3的整数; 核心部分是xanthinyl; 并且R独立地选自胺，氢，卤素，羟基，C（1-10）烷基，C（2-10）烯基，2-溴丙基，4-氯戊基，环己基，环戊基，3-二甲基氨基丁基， 2-羟基乙基，5-羟基己基，3-羟基 - 正丁基，3-羟基丙基，2-甲氧基乙基，4-甲氧基 - 正丁基，苯基和式I，至少一个R包括式I其中（CH 2）n任选被取代; n是从5到20的整数; 每个R 1或R 2独立地为氢或本文定义的任选取代的基团; 并且其中当（CH 2）n，R 1或R 2被取代时，取代基选自氨基甲酰基，伯，仲和叔氨基，C（2-8）烯基，C（1-8）烷基， C（1-8）烷氧基，C（1-8）羟基烷基，叠氮基，碳酸根，羰基，羧基，氰基，C（1-8）卤代烷基，异氰基，异构体巯基，磷酸根，膦酸根，磺酸根，烷基磺酰基，烷基亚砜基，巯基羰基，巯基羰基，硫脲基和脲基。

8. 发明授权

US5057417A Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein 失效
标题翻译：合成生长激素受体和生长激素结合蛋白的组合物和方法
公开(公告)号：US5057417A
公开(公告)日：1991-10-15
申请号：US62542
申请日：1987-06-12
申请人： R. Glenn Hammonds , David W. Leung , Steven A. Spencer , William I. Wood
发明人： R. Glenn Hammonds , David W. Leung , Steven A. Spencer , William I. Wood
IPC分类号： C12N15/09 , A61K38/00 , A61P3/00 , C07K14/00 , C07K14/575 , C07K14/61 , C07K14/705 , C07K14/71 , C07K14/72 , C12N5/10 , C12N15/18 , C12P21/02 , C12R1/91 , G01N33/74
CPC分类号： G01N33/74 , C07K14/71 , A61K38/00
摘要： Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expression systems for recombinant production of growth hormone receptor and growth hormone binding protein. Therapeutically useful forms of the growth hormone receptor and growth hormone binding protein and anti-receptor antibodies are described.
摘要翻译：纯化生长激素受体和生长激素结合蛋白，使氨基酸序列和编码生长激素受体和生长激素结合蛋白的DNA分离物和获得此类DNA的方法与生物激素受体和生长激素重组生产的表达系统一起提供结合蛋白。描述了生长激素受体和生长激素结合蛋白和抗受体抗体的治疗上有用的形式。

9. 发明授权

US07135314B1 Human phosphatidic acid phosphatase 失效
标题翻译：人磷脂酸磷酸酶
公开(公告)号：US07135314B1
公开(公告)日：2006-11-14
申请号：US08842827
申请日：1997-04-17
申请人： David W. Leung , Christopher K. Tompkins
发明人： David W. Leung , Christopher K. Tompkins
IPC分类号： C12N9/16 , C12N15/55 , C12P7/64
CPC分类号： C12P13/001 , C12N9/16 , C12P7/6463 , C12P7/6481 , C12P13/02
摘要： This invention relates to a biotechnology invention concerning human phosphatidic acid phosphatase. More particularly, this invention relates to three variants of human phosphatidic acid phosphatase namely PAP-α(1 and 2), PAP-β and PAP-γ and uses thereof.
摘要翻译：本发明涉及涉及人类磷脂酸磷酸酶的生物技术发明。更具体地说，本发明涉及人磷脂酸磷酸酶的三种变体，即PAP-α（1和2），PAP-β和PAP-γ及其用途。

10. 发明授权

US06973419B1 Method and system for designing an impingement film floatwall panel system 有权
标题翻译：冲击膜浮法面板系统设计方法及系统
公开(公告)号：US06973419B1
公开(公告)日：2005-12-06
申请号：US09517567
申请日：2000-03-02
申请人： Thomas B. Fortin , Gregory E. Chetta , David W. Leung , Duncan C. Meyers , Keith C. Belson , John V. Diaz , Thomas E. Holladay , Scott A. Ladd , Randall G. McKinney , Sergio Rinella , Andreas Sadil , George F. Titterton, III
发明人： Thomas B. Fortin , Gregory E. Chetta , David W. Leung , Duncan C. Meyers , Keith C. Belson , John V. Diaz , Thomas E. Holladay , Scott A. Ladd , Randall G. McKinney , Sergio Rinella , Andreas Sadil , George F. Titterton, III
IPC分类号： F23R3/00 , G06G7/48
CPC分类号： F23R3/002 , F23R2900/00018 , F23R2900/03044 , Y02T50/675 , Y10T477/40
摘要： A method and system for designing an impingement film floatwall panel system for a combustion chamber for a gas turbine engine comprising the steps of creating an impingement film floatwall panel knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of impingement film floatwall panels for a combustion chamber, wherein the knowledge base comprises at least one data value signal for each one of the plurality of design rule signals. The steps also include entering a desired data value signal for a selected one of the plurality of parameter signals of an associated element of the impingement film floatwall panels and comparing the entered desired data value signal for the selected one of the plurality of parameters with the corresponding at least one data value signal in the knowledge base for the corresponding one of the plurality of design rule signals. If the result of the step of comparing is such that the entered desired data value signal for the selected one of the plurality of parameter signals is determined to have a first predetermined relationship with respect to the corresponding at least one data value signal in the knowledge base for the selected one of the plurality of design rule signals, create signals representative of a geometric representation of the selected one of the plurality of parameter signals of the associated element of the impingement film floatwall panels.
摘要翻译：一种用于设计用于燃气涡轮发动机的燃烧室的冲击膜浮动面板系统的方法和系统，包括以下步骤：创建冲击膜浮体墙板信息的知识库。知识库相对于燃烧室的冲击膜浮动面板的相关元件的相应多个参数信号具有多个设计规则信号，其中知识库包括至少一个数据值信号，用于多个设计规则信号。这些步骤还包括为冲击薄膜浮动面板的相关元件的多个参数信号中选定的一个参数信号输入期望的数据值信号，并将输入的多个参数中所选择的一个参数的期望数据值信号与相应的所述知识库中的所述多个设计规则信号中的相应一个的至少一个数据值信号。如果比较步骤的结果是使得所输入的多个参数信号中所选择的一个参数信号的期望数据值信号被确定为相对于知识库中相应的至少一个数据值信号具有第一预定关系对于所选择的多个设计规则信号中的一个，创建表示冲击膜浮体面板的相关元件的多个参数信号中所选择的一个的几何表示的信号。

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