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1. 发明专利

IL180524A PROCESS FOR PREPARING N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)-PHENOXY]-PENTOXY}-BENZAMIDINE 未知
公开(公告)号：IL180524A
公开(公告)日：2011-12-29
申请号：IL18052407
申请日：2007-01-03
申请人： DONG WHA PHARM CO LTD , LEE JIN SOO , AHN SEOK HOON , JIN YOUNG GOO , PARK JAE HOON , SHIN DONG HYUK , CHO EUN HEE , CHANG HWAN BONG , JUNG YOUNG HO
发明人： LEE JIN SOO , AHN SEOK HOON , JIN YOUNG GOO , PARK JAE HOON , SHIN DONG HYUK , CHO EUN HEE , CHANG HWAN BONG , JUNG YOUNG HO
摘要： This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.

2. 发明专利

IL180985A N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY}BENZAMIDINE BIS(METHANESULFONATE), A METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS AND ORAL FORMULATIONS THEREOF 未知
公开(公告)号：IL180985A
公开(公告)日：2012-02-29
申请号：IL18098507
申请日：2007-01-25
申请人： DONG WHA PHARM CO LTD , LEE JIN SOO , RYU JEI MAN , AHN SEOK HOON , JIN YOUNG GOO , SHIN DONG HYUK , CHO EUN HEE , SEONG SEUNG KYOO , CHO SOON KI , JEON CHAN SEOK , LEE KI YOUNG , JUNG SE HYUN
发明人： LEE JIN SOO , RYU JEI MAN , AHN SEOK HOON , JIN YOUNG GOO , SHIN DONG HYUK , CHO EUN HEE , SEONG SEUNG KYOO , CHO SOON KI , JEON CHAN SEOK , LEE KI YOUNG , JUNG SE HYUN
摘要： Disclosed is an N-Hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 methansulfonic acid salt, which has excellent bioavailability. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.

3. 发明申请

WO2008130172A1 N- HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY} BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苯甲胺二乙酸钠盐，其制备方法和包含药物组合物一样
公开(公告)号：WO2008130172A1
公开(公告)日：2008-10-30
申请号：PCT/KR2008/002246
申请日：2008-04-21
申请人： DONG WHA PHARMACEUTICAL IND. CO. LTD. , LEE, Jin Soo , CHO, Soon Ki , SUNG, Seoung Kyoo , JIN, Young Goo , PARK, Jae Hoon , KIM, Bo Kyung , CHA, Ja Hyun , CHO, Eun Hee , RYU, Jei Man
发明人： LEE, Jin Soo , CHO, Soon Ki , SUNG, Seoung Kyoo , JIN, Young Goo , PARK, Jae Hoon , KIM, Bo Kyung , CHA, Ja Hyun , CHO, Eun Hee , RYU, Jei Man
IPC分类号： C07D277/24 , A61K31/426 , A61P19/00 , A61P37/08
CPC分类号： C07D277/24
摘要： The present invention relates to an N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-l,3-thiazol- 4-yl)phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, a process for the preparation thereof, a pharmaceutical composition for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same, and an oral formulation for preventing and treating osteoporosis, bone fractures or allergic inflammatory diseases, comprising the same.
摘要翻译：本发明涉及N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2乙磺酸盐，其方法其制备方法，用于预防和治疗骨质疏松症，骨折或过敏性炎性疾病的药物组合物及其制备方法，以及用于预防和治疗骨质疏松症，骨折或过敏性炎性疾病的口服制剂。

4. 发明申请

WO2008096987A1 NOVEL IMATINIB CAMSYLATE AND METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：新型樟脑磺酸钠及其制备方法
公开(公告)号：WO2008096987A1
公开(公告)日：2008-08-14
申请号：PCT/KR2008/000639
申请日：2008-02-01
申请人： DONG WHA PHARMACEUTICAL IND. CO. LTD. , OH, Yoon Seok , LIM, Jae Kyung , SHIN, Dong Hyuk , SEONG, Seung Kyoo , LEE, Sang Ho , LEE, Hak Soo , CHO, Eun Hee , RYU, Jei Man
发明人： OH, Yoon Seok , LIM, Jae Kyung , SHIN, Dong Hyuk , SEONG, Seung Kyoo , LEE, Sang Ho , LEE, Hak Soo , CHO, Eun Hee , RYU, Jei Man
IPC分类号： C07D401/14
CPC分类号： C07D401/04
摘要： The present invention relates to a novel imatinib camsylate and a method for preparing the same. Imatinib camsylate according to the present invention has a faster absorption rate and higher absorption concentration in terms of pharmacokinetics, and further has excellent water solubility, as compared to commercially available imatinib mesylate.
摘要翻译：本发明涉及新颖的伊马替尼樟脑磺酸盐及其制备方法。与市售的甲磺酸伊马替尼相比，本发明的伊马替尼樟脑磺酸盐在药代动力学方面具有更快的吸收速率和更高的吸收浓度，并且还具有优异的水溶性。

5. 发明申请

WO2006057507A1 AN ORAL PREPARATION HAVING IMPROVED BIOAVAILABILITY 审中-公开
标题翻译：具有改善生物利用度的口头准备
公开(公告)号：WO2006057507A1
公开(公告)日：2006-06-01
申请号：PCT/KR2005/003950
申请日：2005-11-22
申请人： DONG WHA PHARM.IND.CO., LTD , RYU, Jei Man , CHO, Soon Ki , JUNG, Se Hyun , SEONG, Seung Kyoo , CHO, Eun Hee , AHN, Seok Hoon , KIM, Yun Jung
发明人： RYU, Jei Man , CHO, Soon Ki , JUNG, Se Hyun , SEONG, Seung Kyoo , CHO, Eun Hee , AHN, Seok Hoon , KIM, Yun Jung
IPC分类号： A61K47/30 , A61P19/10
CPC分类号： C07D277/24 , A61K9/143 , A61K31/426
摘要： The present invention relates to an oral preparation of N-hydroxy-4- {5- [4- (5-isopropyl-2 -methyl- 1, 3-thiazol-4-yl)p henoxy] pentoxyl -benzamidine having improved bioavailability . More particularly, the present invention relates to an oral preparation comprising: N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4- yl) phenoxy] pentoxy} -benzamidine or pharmaceutically acceptable salt thereof; and one or more carbonates selected from the group consisting of alkalimetal carbonate, alkalimetal bicarbonate and alkaline earth metal carbonate, and/or one or more disintegrants selected from the group consisting of sodium starch glycolate, carmellose calcium and croscarmellose sodium. The oral preparation according to the present invention inhibits gelation of N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) p henoxy] pentoxy} -benzamidine or pharmaceutically acceptable salt thereof in the early stage of release, which increases dissolution rate and remarkably raises bioavailability.
摘要翻译：本发明涉及具有改善的生物利用度的N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基 - 苄脒的口服制剂。更具体地说，本发明涉及包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒的口服制剂或其药学上可接受的盐; 和一种或多种选自碳酸亚烷基碳酸盐，碱金属碳酸氢盐和碱土金属碳酸盐的碳酸盐，和/或选自淀粉羟乙酸钠，羧甲纤维素钙和交联羧甲基纤维素钠的一种或多种崩解剂。根据本发明的口服制剂抑制N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其药学上可接受的盐在释放的早期阶段，其增加溶解速率并显着提高生物利用度。

6. 发明申请

WO2006004368A1 AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-{5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY }-BENZAMIDINE 审中-公开
标题翻译：制备N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基） - 苯氧基] - 戊氧基} - 苯甲胺的改进方法
公开(公告)号：WO2006004368A1
公开(公告)日：2006-01-12
申请号：PCT/KR2005/002137
申请日：2005-07-05
申请人： DONG WHA PHARMACEUTICAL. IND. CO., LTD. , LEE, Jin Soo , AHN, Seok Hoon , JIN, Young Goo , PARK, Jae Hoon , SHIN, Dong Hyuk , CHO, Eun Hee , CHANG, Hwan Bong , JUNG, Young Ho
发明人： LEE, Jin Soo , AHN, Seok Hoon , JIN, Young Goo , PARK, Jae Hoon , SHIN, Dong Hyuk , CHO, Eun Hee , CHANG, Hwan Bong , JUNG, Young Ho
IPC分类号： C07D277/22
CPC分类号： C07D277/24
摘要： This invention relates to an improved method of preparing N-hydroxy-4-{5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) phenoxy] pentoxy }benzamidine .
摘要翻译：本发明涉及制备N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的改进方法。

7. 发明申请

WO2006057501A1 N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY}BENZAMIDINE 2 METHANSULFONIC ACID SALT 审中-公开
标题翻译： N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苯甲胺2甲磺酸盐
公开(公告)号：WO2006057501A1
公开(公告)日：2006-06-01
申请号：PCT/KR2005/003934
申请日：2005-11-22
申请人： DONG WHA PHARMACEUTICAL. IND. CO., LTD. , RYU, Jei, Man , LEE, Jin, Soo , SHIN, Dong, Hyuk , SEONG, Seung, Kyoo , CHO, Soon, Ki , JEON, Chan, Seok , JIN, Young, Goo , LEE, Ki, Young , JUNG, Se, Hyun , CHO, Eun, Hee
发明人： RYU, Jei, Man , LEE, Jin, Soo , SHIN, Dong, Hyuk , SEONG, Seung, Kyoo , CHO, Soon, Ki , JEON, Chan, Seok , JIN, Young, Goo , LEE, Ki, Young , JUNG, Se, Hyun , CHO, Eun, Hee
IPC分类号： A61K31/426
CPC分类号： C07D277/24 , A61K9/143 , A61K31/426
摘要： Disclosed is an N~Hydroxy-4-{5- [4- (5-isopropyl-2- methyl-1, 3- thiazol- 4-yl)phenoxy] pentoxy} benzamidine 2 methansulfonic acid salt, which has excellent bioavailability. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.
摘要翻译：公开了具有优异生物利用度的N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒2甲磺酸盐。还公开了制备该化合物的方法和包含该化合物的药物组合物。

8. 发明公开

KR20070024690A Pegasus extracts, health foods of various nutritional ingredients such as vegetable extract blends with the theme 审中-公开
标题翻译：空值
公开(公告)号：KR20070024690A
公开(公告)日：2007-03-02
申请号：KR20070010380
申请日：2007-02-01
申请人： CHO EUN HEE
发明人： CHO EUN HEE
IPC分类号： A23L1/30 , A23L1/29
CPC分类号： A23L33/105 , A23V2200/308 , A23V2200/32 , A23V2200/328
摘要： Provided is a dietary supplement which promotes stamina, strengthens muscle and bone, promotes metabolism, reinforces sexual function and prevents the hardening of an artery. The dietary supplement comprises 70 % of an extract of Gastrodia elata Blume(the solid part is 1 % or more); 17.77 % of a vegetable mixture extract(the solid part is 1 % or more) comprising Angelicae Gigantis Radix, jujube, Rehmanniae Radix Preparata and ginger; high fructose corn syrup; vitamin C; and an extract of a grapefruit seed.
摘要翻译：提供了一种促进体力，增强肌肉和骨骼，促进新陈代谢，增强性功能并防止动脉硬化的膳食补充剂。膳食补充剂含天麻提取物的70％（实心部分为1％以上）; 17.77％的植物混合物提取物（固体部分为1％或更多），其包含当归Gig，枣，地黄和姜; 高果糖玉米糖浆维生素C; 和葡萄柚种子的提取物。

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