基本信息:
- 专利标题: BCMA T CELL-ANTIGEN COUPLERS AND USES THEREOF
- 申请号:PCT/CA2022/051024 申请日:2022-06-24
- 公开(公告)号:WO2022266778A1 公开(公告)日:2022-12-29
- 发明人: BRAMSON, Jonathan Lorne , HAMMILL, Joanne Alicia , HELSEN, Christopher W.
- 申请人: MCMASTER UNIVERSITY
- 申请人地址: 175 Longwood Road South, Suite 305
- 专利权人: MCMASTER UNIVERSITY
- 当前专利权人: MCMASTER UNIVERSITY
- 当前专利权人地址: 175 Longwood Road South, Suite 305
- 代理机构: SALISBURY, Clare et al.
- 优先权: US63/202,839 2021-06-25
- 主分类号: C12N15/62
- IPC分类号: C12N15/62 ; A61K35/17 ; A61P35/00 ; C07K14/705 ; C07K19/00 ; C12N5/10 ; C12N5/0783 ; C12N15/12 ; C12N15/85 ; C12N15/867 ; A61K2039/505 ; C07K14/70514 ; C07K14/70578 ; C07K16/2809 ; C07K16/2878 ; C07K2317/31 ; C07K2317/622 ; C07K2319/00
摘要:
BCMA T cell antigen coupler (TAC) polypeptides having (i) an antigen-binding domain that binds BCMA, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.