发明申请
WO2021195069A1 CHIMERIC ANTIGEN RECEPTOR POLYPEPTIDES AND ASSOCIATED IMMUNOMODULATORY CELLS FOR TREATING ASPERGILLOSIS
审中-公开
基本信息:
- 专利标题： CHIMERIC ANTIGEN RECEPTOR POLYPEPTIDES AND ASSOCIATED IMMUNOMODULATORY CELLS FOR TREATING ASPERGILLOSIS
- 申请号：PCT/US2021/023658 申请日：2021-03-23
- 公开(公告)号：WO2021195069A1 公开(公告)日：2021-09-30
- 发明人： AFTAB, Blake, Tolu , RALPH, Benjamin Alfred William, Rufus , SHEPPARD, Donald, Christopher , LOWARY, Todd, Lambert , SARKAR, Susmita , KHALIL, Amira Ibrahim Aly Mohamed
- 申请人： ATARA BIOTHERAPEUTICS, INC. , THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
- 申请人地址： 611 Gateway Blvd., Suite 900; Edmonton; Montréal
- 专利权人： ATARA BIOTHERAPEUTICS, INC.,THE GOVERNORS OF THE UNIVERSITY OF ALBERTA,THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
- 当前专利权人： ATARA BIOTHERAPEUTICS, INC.,THE GOVERNORS OF THE UNIVERSITY OF ALBERTA,THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
- 当前专利权人地址： 611 Gateway Blvd., Suite 900; Edmonton; Montréal
- 代理机构： HALSTEAD, David, P. et al.
- 优先权： US16/826,681 2020-03-23
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/14 ; C07K16/28 ; A61P31/00 ; C07K14/725 ; A61K35/12 ; A61K2039/505 ; A61K38/00 ; C07K14/7051 ; C07K2317/20 ; C07K2317/21 ; C07K2317/24 ; C07K2317/54 ; C07K2317/55 ; C07K2317/56 ; C07K2319/03 ; G01N2800/26 ; G01N33/56961
摘要：
Disclosed are compositions and methods for targeted treatment of Aspergillus-associated diseases and disorders in mammals, preferably diseases and disorders associated with Aspergillus infection. In particular, chimeric antigen receptor (CAR) T cells are disclosed that can be used with adoptive cell transfer to target and kill Aspergillus. Therefore, also disclosed are methods of providing an anti-Aspergillus immunity in a subject suffering from an Aspergillus-associated disease or disorder that involves adoptive transfer of the disclosed anti-Aspergillus epitope CAR T cells.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/395 | .抗体；免疫球蛋白；免疫血清，例如抗淋巴细胞血清 |