基本信息:
- 专利标题： BINDER SELECTION USING CAPILLARY ELECTROPHORESIS
- 申请号：PCT/CA2019/051820 申请日：2019-12-16
- 公开(公告)号：WO2020124213A1 公开(公告)日：2020-06-25
- 发明人： KRYLOV, Sergey N.
- 申请人： KRYLOV, Sergey N.
- 申请人地址： 295 Hillcrest Ave. Toronto, Ontario M2N 3P5 CA
- 专利权人： KRYLOV, Sergey N.
- 当前专利权人： KRYLOV, Sergey N.
- 当前专利权人地址： 295 Hillcrest Ave. Toronto, Ontario M2N 3P5 CA
- 代理机构： MCMANUS, Kimberly A. et al.
- 优先权： US62/782,720 20181220
- 主分类号： G01N27/447
- IPC分类号： G01N27/447 ; C12Q1/68 ; C12Q1/6813 ; C40B10/00 ; C40B30/04 ; G16B35/00 ; G01N21/25 ; G01N21/64
摘要：
A method of capillary electrophoresis is provided for binder selection. In an embodiment, a capillary electrophoresis method comprises selecting an electroosmotic flow (EOF) in a capillary such that at least one target-binder (TB) complex has a target-binder velocity vector (vTB) co-directed with an electric field vector (E) and at least one non-binder (N) has a non-binder velocity vector (vN) in the opposite direction to the electric field vector (E); introducing a sample comprising the at least one target-binder (TB) complex, the at least one non-binder (N), and at least one running buffer into a capillary inlet of the capillary; applying an electric field directed from the capillary inlet to a capillary outlet of the capillary to separate the at least one target-binder (TB) complex from the at least one non-binder (N); and detecting the at least one target-binder complex.
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N27/00 | 用电、电化学或磁的方法测试或分析材料 |
| --------G01N27/02 | .通过测试阻抗 |
| ----------G01N27/28 | ..电解池部件 |
| ------------G01N27/447 | ...用电泳法 |