发明申请
WO2018044808A1 INHIBITORS OF DUAL LEUCINE ZIPER (DLK) KINASE FOR THE TREATMENT OF DISEASE
审中-公开
基本信息:
- 专利标题： INHIBITORS OF DUAL LEUCINE ZIPER (DLK) KINASE FOR THE TREATMENT OF DISEASE
- 专利标题（中）：双亮氨酸拉链（DLK）激酶抑制剂用于治疗疾病
- 申请号：PCT/US2017/048941 申请日：2017-08-28
- 公开(公告)号：WO2018044808A1 公开(公告)日：2018-03-08
- 发明人： SOTH, Michael, J. , JONES, Philip , RAY, James , LIU, Gang , LE, Kang , CROSS, Jason
- 申请人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
- 申请人地址： 201 W. 7th Street Austin, TX 78701 US
- 专利权人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人地址： 201 W. 7th Street Austin, TX 78701 US
- 代理机构： HATHAWAY, Cynthia
- 优先权： US62/380,822 20160829
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4178 ; C07D401/04
摘要：
Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g. Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, progressive supranuclear palsy, Lewy body disease, Kennedy's disease, and other related conditions), from neuropathies resulting from neurological damage (chemotherapy -induced peripheral neuropathy, diabetic neuropathy, and related conditions) and from cognitive disorders caused by pharmacological intervention (e.g. chemotherapy induced cognitive disorder, also known as chemobrain).
摘要（中）：
本文公开了抑制双亮氨酸拉链（DLK）激酶（MAP3K12）的激酶活性的化合物，药物组合物以及治疗DLK介导的疾病例如由创伤引起的神经疾病的方法 中枢神经系统和外周神经系统神经元损伤（例如中风，创伤性脑损伤，脊髓损伤）或由慢性神经变性疾病（例如阿尔茨海默氏病，额颞叶痴呆，帕金森病，亨廷顿病，肌萎缩侧索硬化，脊髓小脑 共济失调，进行性核上性麻痹，路易体疾病，肯尼迪氏病和其它相关病症），神经病损伤（化学疗法诱导的周围神经病，糖尿病性神经病和相关病症）和由药理学干预（例如化学疗法 诱导认知障碍，也称为化学细胞）。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/44 | ....非稠合的吡啶；其氢化的衍生物 |