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1. 发明申请

WO2016033416A1 BROMODOMAIN INHIBITORS FOR TREATING DISEASE 审中-公开
标题翻译：用于治疗疾病的BROMODOMAIN抑制剂
公开(公告)号：WO2016033416A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047361
申请日：2015-08-28
申请人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM , PALMER, Wylie , JONES, Philip , LIU, Gang , PETROCCHI, Alessia , REYNA, Naphtali , SUBRUMANIAN, Govindan , THEROFF, Jay , YAU, Anne
发明人： PALMER, Wylie , JONES, Philip , LIU, Gang , PETROCCHI, Alessia , REYNA, Naphtali , SUBRUMANIAN, Govindan , THEROFF, Jay , YAU, Anne
IPC分类号： A01N41/02
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/498 , A61K31/5377 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D235/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , Y02A50/411 , A61K2300/00
摘要： Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.
摘要翻译：本文公开了可用于治疗含有溴结构域的蛋白质介导的疾病（例如癌症）的化合物和组合物，其具有式I的结构：还提供了抑制人类或动物受试者中含有溴结构域的蛋白质的活性的方法。

2. 发明申请

WO2016004404A2 GLS1 INHIBITORS FOR TREATING DISEASE 审中-公开
标题翻译： GLS1用于治疗疾病的抑制剂
公开(公告)号：WO2016004404A2
公开(公告)日：2016-01-07
申请号：PCT/US2015/039134
申请日：2015-07-02
申请人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC分类号： C07D417/14 , A61K31/4439
CPC分类号： C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
摘要翻译：本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。 / p>

3. 发明申请

WO2018044808A1 INHIBITORS OF DUAL LEUCINE ZIPER (DLK) KINASE FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：双亮氨酸拉链（DLK）激酶抑制剂用于治疗疾病
公开(公告)号：WO2018044808A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/048941
申请日：2017-08-28
申请人： BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人： SOTH, Michael, J. , JONES, Philip , RAY, James , LIU, Gang , LE, Kang , CROSS, Jason
IPC分类号： A61K31/44 , A61K31/4178 , C07D401/04
摘要： Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g. Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, progressive supranuclear palsy, Lewy body disease, Kennedy's disease, and other related conditions), from neuropathies resulting from neurological damage (chemotherapy -induced peripheral neuropathy, diabetic neuropathy, and related conditions) and from cognitive disorders caused by pharmacological intervention (e.g. chemotherapy induced cognitive disorder, also known as chemobrain).
摘要翻译：本文公开了抑制双亮氨酸拉链（DLK）激酶（MAP3K12）的激酶活性的化合物，药物组合物以及治疗DLK介导的疾病例如由创伤引起的神经疾病的方法中枢神经系统和外周神经系统神经元损伤（例如中风，创伤性脑损伤，脊髓损伤）或由慢性神经变性疾病（例如阿尔茨海默氏病，额颞叶痴呆，帕金森病，亨廷顿病，肌萎缩侧索硬化，脊髓小脑共济失调，进行性核上性麻痹，路易体疾病，肯尼迪氏病和其它相关病症），神经病损伤（化学疗法诱导的周围神经病，糖尿病性神经病和相关病症）和由药理学干预（例如化学疗法诱导认知障碍，也称为化学细胞）。

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