基本信息:
- 专利标题： PYRAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
- 专利标题（中）：PYRAZOLYL PYRIMIDINONE化合物作为PDE2抑制剂
- 申请号：PCT/US2016/023344 申请日：2016-03-21
- 公开(公告)号：WO2016154081A1 公开(公告)日：2016-09-29
- 发明人： SHEN, Dong-Ming , YANG, Meng , CRESPO, Alexander , WILSON, Jonathan, E. , MCCRACKEN, Troy , WANG, Deping , PARKER, Dann , GUO, Zack Zhiqiang
- 申请人： MERCK SHARP & DOHME CORP. , SHEN, Dong-Ming , YANG, Meng , CRESPO, Alexander , WILSON, Jonathan, E. , MCCRACKEN, Troy , WANG, Deping , PARKER, Dann , GUO, Zack Zhiqiang
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,SHEN, Dong-Ming,YANG, Meng,CRESPO, Alexander,WILSON, Jonathan, E.,MCCRACKEN, Troy,WANG, Deping,PARKER, Dann,GUO, Zack Zhiqiang
- 当前专利权人： MERCK SHARP & DOHME CORP.,SHEN, Dong-Ming,YANG, Meng,CRESPO, Alexander,WILSON, Jonathan, E.,MCCRACKEN, Troy,WANG, Deping,PARKER, Dann,GUO, Zack Zhiqiang
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US62/138,429 20150326
- 主分类号： A01N43/90
- IPC分类号： A01N43/90 ; A61K31/535
摘要：
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要（中）：
本发明涉及可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病的治疗剂的式I的嘧啶甲酰胺化合物。 本发明还涉及这些化合物用于治疗精神分裂症，精神病，帕金森病，帕金森病痴呆（PDD）或亨廷顿舞蹈症等神经和精神疾病以及与纹状体功能不全或基底神经节功能障碍相关的疾病的用途。