基本信息:
- 专利标题: TARGETED NANOCARRIERS FOR THE ADMINISTRATION OF IMMUNOSUPPRESSIVE AGENTS
- 专利标题(中):用于管理免疫抑制剂的目标纳米颗粒
- 申请号:PCT/US2015/011310 申请日:2015-01-14
- 公开(公告)号:WO2015108912A1 公开(公告)日:2015-07-23
- 发明人: BROOME, Ann-Marie , DIXIT, Suraj , NADIG, Satish , ATKINSON, Carl
- 申请人: MUSC FOUNDATION FOR RESEARCH AND DEVELOPMENT
- 申请人地址: Suite 909 19 Hagood Avenue Charleston, South Carolina 29425 US
- 专利权人: MUSC FOUNDATION FOR RESEARCH AND DEVELOPMENT
- 当前专利权人: MUSC FOUNDATION FOR RESEARCH AND DEVELOPMENT
- 当前专利权人地址: Suite 909 19 Hagood Avenue Charleston, South Carolina 29425 US
- 代理机构: GILES, P. Brian et al.
- 优先权: US61/928,277 20140116; US61/974,872 20140403
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K47/48
摘要:
Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.
摘要(中):
公开了一种靶向C3分解产物,整联蛋白或其组合的纳米载体免疫抑制剂,以减少免疫抑制剂的有害全身效应。 还公开了抑制受试者中同种异体免疫应答的方法,例如可以在同种异体移植后发生的同种异体免疫应答。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
--------A61K9/10 | .分散液;乳剂 |
----------A61K9/127 | ..脂质体 |