发明申请
WO2015031166A1 COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOGEN EVOLUTION AND USES THEREOF
审中-公开
基本信息:
- 专利标题: COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOGEN EVOLUTION AND USES THEREOF
- 专利标题(中):用于指导的免疫进化的组合物和方法及其用途
- 申请号:PCT/US2014/052180 申请日:2014-08-21
- 公开(公告)号:WO2015031166A1 公开(公告)日:2015-03-05
- 发明人: BLOOM, Jesse, D.
- 申请人: FRED HUTCHINSON CANCER RESEARCH CENTER
- 申请人地址: 1100 Fairview Avenue North J2-110 Seattle, Washington 98109 US
- 专利权人: FRED HUTCHINSON CANCER RESEARCH CENTER
- 当前专利权人: FRED HUTCHINSON CANCER RESEARCH CENTER
- 当前专利权人地址: 1100 Fairview Avenue North J2-110 Seattle, Washington 98109 US
- 代理机构: PEPE, Jeffrey, C. et al.
- 优先权: US61/870,122 20130826
- 主分类号: C12N7/01
- IPC分类号: C12N7/01 ; C12N15/09 ; C40B40/06 ; G01N30/50
摘要:
The present disclosure relates to compositions and methods for using a modified virus that infects a cell only if the virus presents a candidate antigen that binds with high affinity to a target antibody, thereby allowing for generation and identification of immunogens useful, for example, as vaccines.
摘要(中):
本公开涉及使用仅在病毒呈现与靶抗体以高亲和力结合的候选抗原的感染细胞的修饰病毒的组合物和方法,从而允许产生和鉴定可用于例如疫苗的免疫原 。