基本信息:
- 专利标题: METHODS AND COMPOSITIONS EMPLOYING IMMUNOGENIC FUSION PROTEINS
- 专利标题(中):使用免疫原性融合蛋白的方法和组合物
- 申请号:PCT/US2012/030241 申请日:2012-03-23
- 公开(公告)号:WO2012134975A1 公开(公告)日:2012-10-04
- 发明人: TUOMANEN, Elaine , MANN, Elizabeth, R.
- 申请人: ST. JUDE CHILDREN'S RESEARCH HOSPITAL , TUOMANEN, Elaine , MANN, Elizabeth, R.
- 申请人地址: 262 Danny Thomas Place Memphis, TN 38105-2794 US
- 专利权人: ST. JUDE CHILDREN'S RESEARCH HOSPITAL,TUOMANEN, Elaine,MANN, Elizabeth, R.
- 当前专利权人: ST. JUDE CHILDREN'S RESEARCH HOSPITAL,TUOMANEN, Elaine,MANN, Elizabeth, R.
- 当前专利权人地址: 262 Danny Thomas Place Memphis, TN 38105-2794 US
- 代理机构: WILLIAMSON, Kelly, J. et al.
- 优先权: US61/468,407 20110328
- 主分类号: C07K14/315
- IPC分类号: C07K14/315 ; C12N15/62 ; A61K39/02 ; C12N5/10
摘要:
Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof.
摘要(中):
提供组合物和方法用于预防和治疗细菌感染,包括肺炎球菌感染。 本文提供的组合物包含多种免疫原性融合蛋白,其中给定融合蛋白的至少一种多肽组分包含CbpA多肽和/或细胞溶质多肽,或其活性变体或片段。 提供了通过使用具有至少一种包含CbpA多肽和/或细胞溶质多肽的多肽组分的各种免疫原性融合蛋白或其活性变体或片段来预防和治疗细菌感染(包括肺炎球菌感染)的方法。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07K | 肽 |
------C07K14/00 | 具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物 |
--------C07K14/005 | .来自病毒 |
----------C07K14/315 | ..来自链球菌属(G),例如肠球菌 |