基本信息:
- 专利标题: AZAINDAZOLE COMPOUNDS
- 专利标题(中):AZAINDAZOLE化合物
- 申请号:PCT/US2011/043962 申请日:2011-07-14
- 公开(公告)号:WO2012009510A1 公开(公告)日:2012-01-19
- 发明人: VELAPARTHI, Upender , FRENNESSON, David B. , SAULNIER, Mark G. , AUSTIN, Joel F. , HUANG, Audris , BALOG, James Aaron , VYAS, Dolatrai M.
- 申请人: BRISTOL-MYERS SQUIBB COMPANY , VELAPARTHI, Upender , FRENNESSON, David B. , SAULNIER, Mark G. , AUSTIN, Joel F. , HUANG, Audris , BALOG, James Aaron , VYAS, Dolatrai M.
- 申请人地址: Route 206 and Province Line Road Princeton, New Jersey 08543-4000 US
- 专利权人: BRISTOL-MYERS SQUIBB COMPANY,VELAPARTHI, Upender,FRENNESSON, David B.,SAULNIER, Mark G.,AUSTIN, Joel F.,HUANG, Audris,BALOG, James Aaron,VYAS, Dolatrai M.
- 当前专利权人: BRISTOL-MYERS SQUIBB COMPANY,VELAPARTHI, Upender,FRENNESSON, David B.,SAULNIER, Mark G.,AUSTIN, Joel F.,HUANG, Audris,BALOG, James Aaron,VYAS, Dolatrai M.
- 当前专利权人地址: Route 206 and Province Line Road Princeton, New Jersey 08543-4000 US
- 代理机构: GREENBLATT, Gary D. et al.
- 优先权: US61/364,589 20100715
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/437 ; A61P35/00
摘要:
Disclosed are azaindazole compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein W is CR 4 or N; and R 1 , R 2 , R 3 , and R 4 are defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
摘要(中):
公开了式(I)的氮杂咔唑化合物或其药学上可接受的盐,其中W是CR 4或N; 并且R 1,R 2,R 3和R 4在本文中定义。 还公开了使用这些化合物治疗至少一种CYP17相关病症例如癌症的方法,以及包含这些化合物的药物组合物。
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物,C07D451/00至C07D463/00不包括的 |
--------C07D471/02 | .在稠环系中含两个杂环 |
----------C07D471/04 | ..邻位稠环系 |