基本信息:
- 专利标题： PYRAZOLYL QUINAZOLINE KINASE INHIBITORS
- 专利标题（中）：吡唑啉喹啉激酶抑制剂
- 申请号：PCT/GB2011/050851 申请日：2011-04-28
- 公开(公告)号：WO2011135376A1 公开(公告)日：2011-11-03
- 发明人： SAXTY, Gordon , MURRAY, Christopher William , BERDINI, Valerio , BESONG, Gilbert Ebai , HAMLETT, Christopher Charles Frederick , JOHNSON, Christopher Norbert , WOODHEAD, Steven John , READER, Michael , REES, David Charles , MEVELLEC, Laurence Anne , ANGIBAUD, Patrick René , FREYNE, Eddy Jean Edgard , GOVAERTS, Tom Cornelis Hortense , WEERTS, Johan Erwin Edmond , PERERA, Timothy Pietro Suren , GILISSEN, Ronaldus Arnodus Hendrika Joseph , WROBLOWSKI, Berthold , LACRAMPE, Jean Fernand Armand , PAPANIKOS, Alexandra , QUEROLLE, Oliver Alexis Georges , PASQUIER, Elisabeth Thérèse Jeanne , PILATTE, Isabelle Noëlle Constance , BONNET, Pascal Ghislain André , EMBRECHTS, Werner Constant Johan , AKKARI, Rhalid , MEERPOEL, Lieven
- 申请人： ASTEX THERAPEUTICS LIMITED , SAXTY, Gordon , MURRAY, Christopher William , BERDINI, Valerio , BESONG, Gilbert Ebai , HAMLETT, Christopher Charles Frederick , JOHNSON, Christopher Norbert , WOODHEAD, Steven John , READER, Michael , REES, David Charles , MEVELLEC, Laurence Anne , ANGIBAUD, Patrick René , FREYNE, Eddy Jean Edgard , GOVAERTS, Tom Cornelis Hortense , WEERTS, Johan Erwin Edmond , PERERA, Timothy Pietro Suren , GILISSEN, Ronaldus Arnodus Hendrika Joseph , WROBLOWSKI, Berthold , LACRAMPE, Jean Fernand Armand , PAPANIKOS, Alexandra , QUEROLLE, Oliver Alexis Georges , PASQUIER, Elisabeth Thérèse Jeanne , PILATTE, Isabelle Noëlle Constance , BONNET, Pascal Ghislain André , EMBRECHTS, Werner Constant Johan , AKKARI, Rhalid , MEERPOEL, Lieven
- 申请人地址： 436 Cambridge Science Park Milton Road Cambridge Cambridgeshire CB4 0QA GB
- 专利权人： ASTEX THERAPEUTICS LIMITED,SAXTY, Gordon,MURRAY, Christopher William,BERDINI, Valerio,BESONG, Gilbert Ebai,HAMLETT, Christopher Charles Frederick,JOHNSON, Christopher Norbert,WOODHEAD, Steven John,READER, Michael,REES, David Charles,MEVELLEC, Laurence Anne,ANGIBAUD, Patrick René,FREYNE, Eddy Jean Edgard,GOVAERTS, Tom Cornelis Hortense,WEERTS, Johan Erwin Edmond,PERERA, Timothy Pietro Suren,GILISSEN, Ronaldus Arnodus Hendrika Joseph,WROBLOWSKI, Berthold,LACRAMPE, Jean Fernand Armand,PAPANIKOS, Alexandra,QUEROLLE, Oliver Alexis Georges,PASQUIER, Elisabeth Thérèse Jeanne,PILATTE, Isabelle Noëlle Constance,BONNET, Pascal Ghislain André,EMBRECHTS, Werner Constant Johan,AKKARI, Rhalid,MEERPOEL, Lieven
- 当前专利权人： ASTEX THERAPEUTICS LIMITED,SAXTY, Gordon,MURRAY, Christopher William,BERDINI, Valerio,BESONG, Gilbert Ebai,HAMLETT, Christopher Charles Frederick,JOHNSON, Christopher Norbert,WOODHEAD, Steven John,READER, Michael,REES, David Charles,MEVELLEC, Laurence Anne,ANGIBAUD, Patrick René,FREYNE, Eddy Jean Edgard,GOVAERTS, Tom Cornelis Hortense,WEERTS, Johan Erwin Edmond,PERERA, Timothy Pietro Suren,GILISSEN, Ronaldus Arnodus Hendrika Joseph,WROBLOWSKI, Berthold,LACRAMPE, Jean Fernand Armand,PAPANIKOS, Alexandra,QUEROLLE, Oliver Alexis Georges,PASQUIER, Elisabeth Thérèse Jeanne,PILATTE, Isabelle Noëlle Constance,BONNET, Pascal Ghislain André,EMBRECHTS, Werner Constant Johan,AKKARI, Rhalid,MEERPOEL, Lieven
- 当前专利权人地址： 436 Cambridge Science Park Milton Road Cambridge Cambridgeshire CB4 0QA GB
- 代理机构： BARKER BRETTELL LLP
- 优先权： US61/329,884 20100430; GB1007286.6 20100430
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D487/08 ; A61K31/498 ; A61P35/00
摘要：
The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要（中）：
本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。 癌症。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D403/00 | 杂环化合物，含有两个或更多的杂环，以氮原子作为仅有的杂环原子，C07D401/00组不包含的 |
| --------C07D403/02 | .含两个杂环 |
| ----------C07D403/04 | ..被环原子—环原子的键直接连接的 |