基本信息:
- 专利标题： HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR
- 申请号：PCT/US2009/030602 申请日：2009-01-09
- 公开(公告)号：WO2009089453A9 公开(公告)日：2009-07-16
- 发明人： BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
- 申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
- 申请人地址： 3200 Walnut Street Boulder, Colorado 80301 US
- 专利权人： ARRAY BIOPHARMA INC.,GENENTECH, INC.,BENCSIK, Josef,BLAKE, James, F.,KALLAN, Nicholas, C.,MITCHELL, Ian, S.,SPENCER, Keith, L.,XIAO, Dengming,XU, Rui,CHABOT, Christine,DO, Steven,LIANG, Jun,SAFINA, Brian,ZHANG, Birong
- 当前专利权人： ARRAY BIOPHARMA INC.,GENENTECH, INC.,BENCSIK, Josef,BLAKE, James, F.,KALLAN, Nicholas, C.,MITCHELL, Ian, S.,SPENCER, Keith, L.,XIAO, Dengming,XU, Rui,CHABOT, Christine,DO, Steven,LIANG, Jun,SAFINA, Brian,ZHANG, Birong
- 当前专利权人地址： 3200 Walnut Street Boulder, Colorado 80301 US
- 代理机构： HARRIS, Robert, J. et al.
- 优先权： US61/020,087 20080109
- 主分类号： C07D239/70
- IPC分类号： C07D239/70 ; A61K31/517 ; A61P35/00
摘要：
The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D239/00 | 杂环化合物，含1,3-二嗪环或氢化1,3-二嗪环 |
| --------C07D239/70 | .与碳环或碳环系稠合 |