基本信息:
- 专利标题： HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR
- 专利标题（中）：羟丙基吡咯烷酮作为AKT蛋白激酶抑制剂
- 申请号：PCT/US2009/030602 申请日：2009-01-09
- 公开(公告)号：WO2009089453A1 公开(公告)日：2009-07-16
- 发明人： BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
- 申请人： ARRAY BIOPHARMA INC. , GENENTECH, INC. , BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
- 申请人地址： 3200 Walnut Street Boulder, Colorado 80301 US
- 专利权人： ARRAY BIOPHARMA INC.,GENENTECH, INC.,BENCSIK, Josef,BLAKE, James, F.,KALLAN, Nicholas, C.,MITCHELL, Ian, S.,SPENCER, Keith, L.,XIAO, Dengming,XU, Rui,CHABOT, Christine,DO, Steven,LIANG, Jun,SAFINA, Brian,ZHANG, Birong
- 当前专利权人： ARRAY BIOPHARMA INC.,GENENTECH, INC.,BENCSIK, Josef,BLAKE, James, F.,KALLAN, Nicholas, C.,MITCHELL, Ian, S.,SPENCER, Keith, L.,XIAO, Dengming,XU, Rui,CHABOT, Christine,DO, Steven,LIANG, Jun,SAFINA, Brian,ZHANG, Birong
- 当前专利权人地址： 3200 Walnut Street Boulder, Colorado 80301 US
- 代理机构： HARRIS, Robert, J. et al.
- 优先权： US61/020,087 20080109
- 主分类号： C07D239/70
- IPC分类号： C07D239/70 ; A61K31/517 ; A61P35/00
摘要：
The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
摘要（中）：
本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D239/00 | 杂环化合物，含1,3-二嗪环或氢化1,3-二嗪环 |
| --------C07D239/70 | .与碳环或碳环系稠合 |