基本信息:
- 专利标题： 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
- 专利标题（中）：作为激酶抑制剂的5-HETEROARYL取代的吲哚美辛
- 申请号：PCT/US2008/065727 申请日：2008-06-04
- 公开(公告)号：WO2008154241A1 公开(公告)日：2008-12-18
- 发明人： AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric T , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine
- 申请人： ABBOTT LABORATORIES , AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric T , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine
- 申请人地址： 100 Abbott Park Road Abbott Park, Illinois 60064 US
- 专利权人： ABBOTT LABORATORIES,AKRITOPOULOU-ZANZE, Irini,WAKEFIELD, Brian D,MACK, Helmut,TURNER, Sean C,GASIECKI, Alan F,GRACIAS, Vijaya J,SARRIS, Kathy,KALVIN, Douglas M,MICHMERHUIZEN, Melissa J,SHUAI, Qi,PATEL, Jyoti R,BAKKER, Margaretha,TEUSCH, Nicole,JOHNSON, Eric T,KOVAR, Peter J,DJURIC, Stevan W,LONG, Andrew J,VASUDEVAN, Anil,HOBSON, Adrian,ST. JOHN MOORE, Nigel,WANG, Lu,GEORGE, Dawn,LI, Biqin,FRANK, Kristine
- 当前专利权人： ABBOTT LABORATORIES,AKRITOPOULOU-ZANZE, Irini,WAKEFIELD, Brian D,MACK, Helmut,TURNER, Sean C,GASIECKI, Alan F,GRACIAS, Vijaya J,SARRIS, Kathy,KALVIN, Douglas M,MICHMERHUIZEN, Melissa J,SHUAI, Qi,PATEL, Jyoti R,BAKKER, Margaretha,TEUSCH, Nicole,JOHNSON, Eric T,KOVAR, Peter J,DJURIC, Stevan W,LONG, Andrew J,VASUDEVAN, Anil,HOBSON, Adrian,ST. JOHN MOORE, Nigel,WANG, Lu,GEORGE, Dawn,LI, Biqin,FRANK, Kristine
- 当前专利权人地址： 100 Abbott Park Road Abbott Park, Illinois 60064 US
- 代理机构： DONNER, B. Gregory
- 优先权： US60/933,960 20070608
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D413/04 ; C07D417/04
摘要：
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R 1 , R 2 , R 3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
摘要（中）：
本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。 本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶如糖原合酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），AKT，PAK4 ，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D403/00 | 杂环化合物，含有两个或更多的杂环，以氮原子作为仅有的杂环原子，C07D401/00组不包含的 |
| --------C07D403/02 | .含两个杂环 |
| ----------C07D403/04 | ..被环原子—环原子的键直接连接的 |