基本信息:
- 专利标题： INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF
- 申请号：PCT/US2008/007104 申请日：2008-06-05
- 公开(公告)号：WO2008153926A4 公开(公告)日：2008-12-18
- 发明人： SCHLESSINGER, Joseph , LAX, Irit , YUZAWA, Satoru , OPATOWSKY, Yarden , YANG, Yan
- 申请人： YALE UNIVERSITY , SCHLESSINGER, Joseph , LAX, Irit , YUZAWA, Satoru , OPATOWSKY, Yarden , YANG, Yan
- 申请人地址： Two Whitney Avenue New Haven, CT 06511 US
- 专利权人： YALE UNIVERSITY,SCHLESSINGER, Joseph,LAX, Irit,YUZAWA, Satoru,OPATOWSKY, Yarden,YANG, Yan
- 当前专利权人： YALE UNIVERSITY,SCHLESSINGER, Joseph,LAX, Irit,YUZAWA, Satoru,OPATOWSKY, Yarden,YANG, Yan
- 当前专利权人地址： Two Whitney Avenue New Haven, CT 06511 US
- 代理机构： ZACHARAKIS, J.D., Maria Laccotripe et al.
- 优先权： US60/933,238 20070605; US61/009,482 20071228; US61/070,506 20080324
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395
摘要：
The present invention provides moieties that bind to an Ig-like domain, e.g. , D4 or D5, of a human receptor tyrosine kinase, e.g. , the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |