发明申请
WO2008083357A1 BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
审中-公开
基本信息:
- 专利标题： BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
- 专利标题（中）：桥联双糖环和双桥双环取代三唑类有用的AXL抑制剂
- 申请号：PCT/US2007/089156 申请日：2007-12-28
- 公开(公告)号：WO2008083357A1 公开(公告)日：2008-07-10
- 发明人： GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , DING, Pingyu , YU, Jiaxin , LITVAK, Joane
- 申请人： RIGEL PHARMACEUTICALS, INC. , GOFF, Dane , ZHANG, Jing , SINGH, Rajinder , HOLLAND, Sacha , DING, Pingyu , YU, Jiaxin , LITVAK, Joane
- 申请人地址： 1180 Veterans Boulevard South San Francisco, California 94080 US
- 专利权人： RIGEL PHARMACEUTICALS, INC.,GOFF, Dane,ZHANG, Jing,SINGH, Rajinder,HOLLAND, Sacha,DING, Pingyu,YU, Jiaxin,LITVAK, Joane
- 当前专利权人： RIGEL PHARMACEUTICALS, INC.,GOFF, Dane,ZHANG, Jing,SINGH, Rajinder,HOLLAND, Sacha,DING, Pingyu,YU, Jiaxin,LITVAK, Joane
- 当前专利权人地址： 1180 Veterans Boulevard South San Francisco, California 94080 US
- 代理机构： ROTH, Carol, J. et al.
- 优先权： US60/882,783 20061229; US60/981,053 20071018
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/4196 ; A61P19/00 ; C07D249/14 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D491/04 ; C07D471/18 ; C07D401/12 ; C07D403/12 ; C07D409/14
摘要：
Bridged bicyclic aryl or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要（中）：
公开了桥连双环芳基或杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。 还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D495/00 | 杂环化合物，在稠环系中至少有1个杂环具有硫原子作为仅有的杂环原子 |
| --------C07D495/02 | .在稠环系中含有两个杂环 |
| ----------C07D495/04 | ..邻位稠合系 |