发明申请
WO2007061690A3 NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRUS INFECTION AND CANCER
审中-公开
基本信息:
- 专利标题： NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRUS INFECTION AND CANCER
- 申请号：PCT/US2006/044176 申请日：2006-11-13
- 公开(公告)号：WO2007061690A3 公开(公告)日：2007-05-31
- 发明人： IADONATO, Shawn, P. , MAGNESS, Charles, L. , BRANUM, Mark , MCVEAN, Maralee , SCHERER, Christina, A.
- 申请人： ILLUMIGEN BIOSCIENCES, INC. , IADONATO, Shawn, P. , MAGNESS, Charles, L. , BRANUM, Mark , MCVEAN, Maralee , SCHERER, Christina, A.
- 申请人地址： 201 Elliot Avenue West, Suite 500 Seattle, Washington 98119 US
- 专利权人： ILLUMIGEN BIOSCIENCES, INC.,IADONATO, Shawn, P.,MAGNESS, Charles, L.,BRANUM, Mark,MCVEAN, Maralee,SCHERER, Christina, A.
- 当前专利权人： ILLUMIGEN BIOSCIENCES, INC.,IADONATO, Shawn, P.,MAGNESS, Charles, L.,BRANUM, Mark,MCVEAN, Maralee,SCHERER, Christina, A.
- 当前专利权人地址： 201 Elliot Avenue West, Suite 500 Seattle, Washington 98119 US
- 代理机构： POTTER, Jane, E.R. et al.
- 优先权： US60/739,159 20051123; US60/752,668 20051221
- 主分类号： C12N9/12
- IPC分类号： C12N9/12
摘要：
The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.