发明申请
WO2007041486A3 MICROFLUIDIC CHIP FOR SYNTHESIZING RADIOACTIVELY LABELED MOLECULES SUITABLE FOR HUMAN IMAGING WITH POSITRON EMISSION TOMOGRAPHY
审中-公开
基本信息:
- 专利标题： MICROFLUIDIC CHIP FOR SYNTHESIZING RADIOACTIVELY LABELED MOLECULES SUITABLE FOR HUMAN IMAGING WITH POSITRON EMISSION TOMOGRAPHY
- 专利标题（中）：用于合成适用于人体成像的放射性标记分子的微流感芯片
- 申请号：PCT/US2006038418 申请日：2006-09-29
- 公开(公告)号：WO2007041486A3 公开(公告)日：2007-06-07
- 发明人： ELIZAROV ARKADIJ M , KOLB HARTMUTH , HEATH JAMES , VAN DAM R MICHAEL
- 申请人： SIEMENS MEDICAL SOLUTIONS , ELIZAROV ARKADIJ M , KOLB HARTMUTH , HEATH JAMES , VAN DAM R MICHAEL
- 专利权人： SIEMENS MEDICAL SOLUTIONS,ELIZAROV ARKADIJ M,KOLB HARTMUTH,HEATH JAMES,VAN DAM R MICHAEL
- 当前专利权人： SIEMENS MEDICAL SOLUTIONS,ELIZAROV ARKADIJ M,KOLB HARTMUTH,HEATH JAMES,VAN DAM R MICHAEL
- 优先权： US72160705 2005-09-29
- 主分类号： B01J19/00
- IPC分类号： B01J19/00
摘要：
The invention concerns automated, inegrated microfluidic devices comprising a chemical reaction chip for performing reactions, such as the preparation of radiopharmaceutical compounds. The chip comprises an integrated microscale column and is configured for liquid flow from the column to at least one flow channel. The fluid flow is controlled by at least two on-chip valves. These double valves are configured consecutively and within proximity of 300 micrometer from each other. The reaction chamber is substantially "coinshaped", e.g. a reaction cylinder, preferably having a height diameter to height ratio greater than 3. Curved inlet and outlet channels ensure en effective elution.
摘要（中）：
本发明涉及包括用于进行反应的化学反应芯片例如制备放射性药物化合物的自动化整合的微流体装置。 该芯片包括集成的微量柱，并被配置用于从柱流到至少一个流动通道的液体流。 流体流动由至少两个片上阀控制。 这些双阀门连续配置，并且距离彼此在300微米附近。 反应室基本上是“硬币”，例如。 反应筒，优选地具有高于3的高度直径与高度之比。弯曲的入口和出口通道确保有效洗脱。