发明申请
WO2007025079A2 DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS2 OR OAS3
审中-公开
基本信息:
- 专利标题： DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO VIRAL INFECTION, OAS2 OR OAS3
- 专利标题（中）：检测与病毒感染相关的基因中的突变，OAS2或OAS3
- 申请号：PCT/US2006/033137 申请日：2006-08-23
- 公开(公告)号：WO2007025079A2 公开(公告)日：2007-03-01
- 发明人： MAGNESS, Charles, L. , IADONATO, Shawn, P. , SCHERER, Christina, A. , FELLIN, Phillip, Campion , STEIGER, Kathryn, V.
- 申请人： ILLUMIGEN BIOSCIENCES, INC. , MAGNESS, Charles, L. , IADONATO, Shawn, P. , SCHERER, Christina, A. , FELLIN, Phillip, Campion , STEIGER, Kathryn, V.
- 申请人地址： 201 Elliot Avenue West, Suite 500, Seattle, Washington 98119 US
- 专利权人： ILLUMIGEN BIOSCIENCES, INC.,MAGNESS, Charles, L.,IADONATO, Shawn, P.,SCHERER, Christina, A.,FELLIN, Phillip, Campion,STEIGER, Kathryn, V.
- 当前专利权人： ILLUMIGEN BIOSCIENCES, INC.,MAGNESS, Charles, L.,IADONATO, Shawn, P.,SCHERER, Christina, A.,FELLIN, Phillip, Campion,STEIGER, Kathryn, V.
- 当前专利权人地址： 201 Elliot Avenue West, Suite 500, Seattle, Washington 98119 US
- 代理机构： POTTER, Jane, E., R. et al.
- 优先权： US60/710,704 20050823
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Compositions and methods are provided for detecting a mutation in a human oligoadenylate synthetase gene, particularly OAS2 or OAS3, wherein the mutation confers resistance to flavivirus infection, including infection by hepatitis C virus, and the mutation relates to other disease states including prostate cancer and diabetes, and uses of the encoded proteins and antibodies thereto.
摘要（中）：
提供组合物和方法用于检测人寡聚腺苷酸合成酶基因，特别是OAS2或OAS3中的突变，其中突变赋予对黄病毒感染的抗性，包括丙型肝炎病毒的感染，并且该突变涉及包括前列腺癌和糖尿病在内的其它疾病状态 ，以及编码的蛋白质及其抗体的用途。