基本信息:
- 专利标题： GLYCOPEPTIDE DIMERS AND USES THEREOF
- 专利标题（中）：谷氨酸二聚体及其用途
- 申请号：PCT/US2005/024273 申请日：2005-07-08
- 公开(公告)号：WO2006017180A2 公开(公告)日：2006-02-16
- 发明人： DANISHEFSKY, Samuel , DUDKIN, Vadim , GENG, Xudong , MANDAL, Mihiribaran , OLSON, William , ORLOVA, Marianna
- 申请人： PROGENICS PHARMACEUTICALS, INC. , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANISHEFSKY, Samuel , DUDKIN, Vadim , GENG, Xudong , MANDAL, Mihiribaran , OLSON, William , ORLOVA, Marianna
- 申请人地址： 777 Old Saw Mill River Road, Tarrytown, NY 10591 US
- 专利权人： PROGENICS PHARMACEUTICALS, INC.,SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH,DANISHEFSKY, Samuel,DUDKIN, Vadim,GENG, Xudong,MANDAL, Mihiribaran,OLSON, William,ORLOVA, Marianna
- 当前专利权人： PROGENICS PHARMACEUTICALS, INC.,SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH,DANISHEFSKY, Samuel,DUDKIN, Vadim,GENG, Xudong,MANDAL, Mihiribaran,OLSON, William,ORLOVA, Marianna
- 当前专利权人地址： 777 Old Saw Mill River Road, Tarrytown, NY 10591 US
- 代理机构： WHITE, John, P.
- 优先权： US60/586,859 20040709
- 主分类号： C07K9/00
- IPC分类号： C07K9/00
摘要：
This invention provides compounds represented by the formula: (A-X---) n wherein each A- is independently a carbohydrate represented by the general structure: wherein each of B, C, D, E, F, G, H, I, and J independently represents a sugar moiety, a sugar moiety having a protecting group attached thereto, a hydrogen, or an oxygen protecting group, provided that no more than two of B, C, D, and E is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and that no more than one of F, G, H, and I is simultaneously a sugar moiety or a sugar moiety having a protecting group attached thereto and wherein represents a covalent bond between the carbohydrate and the peptide; wherein each R 1 independently represents a hydrogen or an oxygen protecting group; wherein each R 2A and each R 2B is independently a hydrogen or a nitrogen protecting group; wherein X is a peptide; wherein --- represents a disulfide bond; and wherein n represents an integer ≥ 2.
摘要（中）：
本发明提供由下式表示的化合物：（A-X ---）